Passive Immunity in Prevention and Treatment of Infectious Diseases
M. A. Keller,E. R. Stiehm +1 more
TLDR
Palivizumab, the first monoclonal antibody licensed for an infectious disease, can prevent respiratory syncytial virus infection in high-risk infants and the development and use of additional monOClonal antibodies to key epitopes of microbial pathogens may further define protective humoral responses and lead to new approaches for the prevention and treatment of infectious diseases.Abstract:
Antibodies have been used for over a century in the prevention and treatment of infectious disease. They are used most commonly for the prevention of measles, hepatitis A, hepatitis B, tetanus, varicella, rabies, and vaccinia. Although their use in the treatment of bacterial infection has largely been supplanted by antibiotics, antibodies remain a critical component of the treatment of diptheria, tetanus, and botulism. High-dose intravenous immunoglobulin can be used to treat certain viral infections in immunocompromised patients (e.g., cytomegalovirus, parvovirus B19, and enterovirus infections). Antibodies may also be of value in toxic shock syndrome, Ebola virus, and refractory staphylococcal infections. Palivizumab, the first monoclonal antibody licensed (in 1998) for an infectious disease, can prevent respiratory syncytial virus infection in high-risk infants. The development and use of additional monoclonal antibodies to key epitopes of microbial pathogens may further define protective humoral responses and lead to new approaches for the prevention and treatment of infectious diseases.read more
Citations
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A brief history of the antibiotic era: lessons learned and challenges for the future.
TL;DR: This article gives a very brief overview of the antibiotic era, beginning from the discovery of first antibiotics until the present day situation, which is marred by the emergence of hard-to-treat multiple antibiotic-resistant infections.
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An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus
Elisabetta Traggiai,Stephan Becker,Kanta Subbarao,Larissa Kolesnikova,Yasushi Uematsu,Maria Rita Gismondo,Brian R. Murphy,Rino Rappuoli,Antonio Lanzavecchia +8 more
TL;DR: The results show that it is possible to interrogate the memory repertoire of immune donors to rapidly and efficiently isolate neutralizing antibodies that have been selected in the course of natural infection.
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The biology and future prospects of antivirulence therapies
TL;DR: The emergence and increasing prevalence of bacterial strains that are resistant to available antibiotics demand the discovery of new therapeutic approaches, and targeting virulence represents a new paradigm to empower the clinician to prevent and treat infectious diseases.
Journal ArticleDOI
Passive Immunization during Pregnancy for Congenital Cytomegalovirus Infection
TL;DR: Treatment of pregnant women with CMV-specific hyperimmune globulin is safe, and the findings of this nonrandomized study suggest that it may be effective in the treatment and prevention of congenital CMV infection.
Journal ArticleDOI
Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association
Jianhua Sui,Wenhui Li,Akikazu Murakami,Azaibi Tamin,Leslie J. Matthews,Swee Kee Wong,Michael Moore,Aimee St. Clair Tallarico,Mobolaji Olurinde,Hyeryun Choe,Larry J. Anderson,William J. Bellini,Michael Farzan,Wayne A. Marasco +13 more
TL;DR: Data suggest that the 80R human monoclonal antibody may be a useful viral entry inhibitor for the emergency prophylaxis and treatment of SARS, and that the ACE2-binding site of S1 could be an attractive target for subunit vaccine and drug development.
References
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Book
Principles and Practice of Infectious Diseases
TL;DR: This updated and expanded edition now offers 297 chapters that cover the basic principles of diagnosis and management, major clinical syndromes, all important pathogenic microbes and the diseases they cause, plus a number of specialised topics useful to the practitioner.
Journal ArticleDOI
Report of the Committee on Infectious Diseases
TL;DR: The Report of the Committee on Infectious Disease (ie, the so-called Red Book) is a source of essential information on the prevention, diagnosis, and treatment of pediatric infectious diseases.
Book
Textbook of pediatric infectious diseases
Ralph D. Feigin,James D. Cherry +1 more
TL;DR: Textbook of pediatric infectious diseases, Textbook of Pediatrics , کتابخانه دیجیتال جندی شاپور اهواز
Journal ArticleDOI
Varicella-zoster virus.
TL;DR: A live attenuated varicella vaccine (Oka/Merck strain) is now recommended for routine childhood immunization and passive antibody prophylaxis withvaricella-zoster immune globulin is indicated for susceptible high-risk patients exposed to variceella.
Journal ArticleDOI
Treatment of Gram-Negative Bacteremia and Shock with Human Antiserum to a Mutant Escherichia coli
Elizabeth J. Ziegler,McCutchan Ja,Joshua Fierer,Michel P. Glauser,Jerald C. Sadoff,Douglas H,Abraham I. Braude +6 more
TL;DR: It is concluded that human antiserum to the lipopolysaccharide core can substantially reduce deaths from gram-negative bacteremia and endotoxin shock.
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