Journal ArticleDOI
PEG-SS-PPS: reduction-sensitive disulfide block copolymer vesicles for intracellular drug delivery.
TLDR
Polymersomes that can protect biomolecules in the extracellular environment, are taken up by endocytosis, and then suddenly burst within the early endosome, releasing their contents prior to exposure to the harsh conditions encountered after lysosomal fusion are reported.About:
This article is published in Biomacromolecules.The article was published on 2007-05-12. It has received 399 citations till now. The article focuses on the topics: Polymersome & Drug carrier.read more
Citations
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Self-assembly of block copolymers
Yiyong Mai,Adi Eisenberg +1 more
TL;DR: The present tutorial review introduces the primary principles of BCP self-assembly in bulk and in solution by describing experiments, theories, accessible morphologies and morphological transitions, factors affecting the morphology, thermodynamics and kinetics, among others.
Journal ArticleDOI
Self-Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications.
TL;DR: This review is focused on the inherent advantages in using polymer vesicles over their small molecule lipid counterparts and the potential applications in biology for both drug delivery and synthetic cellular reactors.
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Future perspectives and recent advances in stimuli-responsive materials
TL;DR: It is the goal to emphasize underutilized adaptive behaviors of stimuli-responsive polymers so that novel applications and new generations of smart materials can be realized.
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Polymers for Drug Delivery Systems
TL;DR: The origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates are reviewed and the latest developments in polymers capable of molecular recognition or directing intracellular delivery are surveyed to illustrate areas of research advancing the frontiers of drug delivery.
Journal ArticleDOI
New directions in thermoresponsive polymers.
TL;DR: By highlighting recent examples of newly developed thermoresponsive polymer systems, it is hoped to promote the development of new generations of smart materials.
References
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Journal ArticleDOI
Polymersomes: tough vesicles made from diblock copolymers.
Bohdana M. Discher,You-Yeon Won,David S. Ege,James C. Lee,Frank S. Bates,Dennis E. Discher,Daniel A. Hammer +6 more
TL;DR: The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry, and both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements.
Journal ArticleDOI
Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities
TL;DR: This review focuses on understanding where and how the disulfide bond in the bioconjugate is reduced upon contact with biological milieu, which affects delivery design and the interpretation of the delivery strategies.
Journal ArticleDOI
On the Origins of Morphological Complexity in Block Copolymer Surfactants
Sumeet Jain,Frank S. Bates +1 more
TL;DR: Experiments with poly(1,2-butadiene-b-ethylene oxide) diblock copolymers are described, which form Y-junctions and three-dimensional networks in water at weight fractions of PEO intermediate to those associated with vesicle and wormlike micelle morphologies.
Journal ArticleDOI
Analysis of glutathione: implication in redox and detoxification.
TL;DR: The present review proposes an analysis of the current knowledge about the methodologies for measuring glutathione in human biological samples and their feasibility as routine methods in clinical chemistry, and elucidates the fundamental role of glutATHione in pathophysiological conditions and its implication in redox and detoxification process.
Journal ArticleDOI
Multifunctional Alloys Obtained via a Dislocation-Free Plastic Deformation Mechanism.
Takashi Saito,Takashi Saito,Tadahiko Furuta,Tadahiko Furuta,Jung Hwan Hwang,Jung Hwan Hwang,Shigeru Kuramoto,Shigeru Kuramoto,Kazuaki Nishino,Kazuaki Nishino,Nobuaki Suzuki,Nobuaki Suzuki,Rong Chen,Rong Chen,Akira Yamada,Akira Yamada,Kazuhiko Ito,Kazuhiko Ito,Yoshiki Seno,Yoshiki Seno,Takamasa Nonaka,Takamasa Nonaka,Hideaki Ikehata,Hideaki Ikehata,Naoyuki Nagasako,Naoyuki Nagasako,Chihiro Iwamoto,Chihiro Iwamoto,Yuuichi Ikuhara,Yuuichi Ikuhara,Taketo Sakuma,Taketo Sakuma +31 more
TL;DR: A group of alloys that exhibit “super” properties, such as ultralow elastic modulus, ultrahigh strength, super elasticity, and super plasticity, at room temperature and that show Elinvar and Invar behavior are described.