Periodontal Disease, Tooth Loss, and Cancer Risk.
TLDR
Existing data provide support for a positive association between periodontal disease and risk of oral, lung, and pancreatic cancers; however, additional prospective studies are needed to better inform on the strength of these associations and to determine whether other cancers are associated with periodonta disease.Abstract:
Periodontal disease, which includes gingivitis and periodontitis, is highly prevalent in adults and disease severity increases with age. The relationship between periodontal disease and oral cancer has been examined for several decades, but there is increasing interest in the link between periodontal disease and overall cancer risk, with systemic inflammation serving as the main focus for biological plausibility. Numerous case-control studies have addressed the role of oral health in head and neck cancer, and several cohort studies have examined associations with other types of cancers over the past decade. For this review, we included studies that were identified from either 11 published reviews on this topic or an updated literature search on PubMed (between 2011 and July 2016). A total of 50 studies from 46 publications were included in this review. Meta-analyses were conducted on cohort and case-control studies separately when at least 4 studies could be included to determine summary estimates of the risk of cancer in relation to 1) periodontal disease or 2) tooth number (a surrogate marker of periodontal disease) with adjustment for smoking. Existing data provide support for a positive association between periodontal disease and risk of oral, lung, and pancreatic cancers; however, additional prospective studies are needed to better inform on the strength of these associations and to determine whether other cancers are associated with periodontal disease. Future studies should include sufficiently large sample sizes, improved measurements for periodontal disease, and thorough adjustment for smoking and other risk factors.read more
Citations
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Association between periodontal pathogens and systemic disease
Fiona Q. Bui,Cássio Luiz Coutinho Almeida-da-Silva,Brandon Triell Huynh,Alston Trinh,Jessica Liu,Jacob Woodward,Homer Asadi,David M. Ojcius +7 more
TL;DR: A growing body of literature suggests that there is a link between periodontitis and systemic diseases, which include cardiovascular disease, gastrointestinal and colorectal cancer, diabetes and insulin resistance, and Alzheimer's disease.
Journal ArticleDOI
Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases
TL;DR: Recent evidence for the interrelationship between chronic periodontitis and other prevalent chronic diseases such as cardiovascular diseases, diabetes, cancer and chronic respiratory diseases is summarized and inflammatory cytokines such as TNF-alpha, IL-1, and IL-6 are focused on.
Journal ArticleDOI
The Human Oral Microbiome in Health and Disease: From Sequences to Ecosystems.
Jesse R. Willis,Toni Gabaldón +1 more
TL;DR: This review surveys the main sequencing-based methodologies that are currently used to explore the oral microbiome and highlights major findings enabled by these approaches, and discusses future prospects in the field.
Journal ArticleDOI
Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression
Lishay Parhi,Tamar Alon-Maimon,Asaf Sol,Deborah Nejman,Amjad Shhadeh,Tanya Fainsod-Levi,Olga Yajuk,Batya Isaacson,Jawad Abed,Naseem Maalouf,Aviram Nissan,Judith Sandbank,Einav Yehuda-Shnaidman,Falk Ponath,Jörg Vogel,Ofer Mandelboim,Zvi Granot,Ravid Straussman,Gilad Bachrach +18 more
TL;DR: It is shown that Fusobacterium nucleatum is abundant in breast cancer samples and that the colonization by F. nucleatum accelerates tumor growth and metastasis in preclinical breast cancer models.
Journal ArticleDOI
Periodontal Ligament Stem Cells: Regenerative Potency in Periodontium
TL;DR: Recent research advancement and accumulated information regarding the self-renewal capacity, multipotency, and immunomoduratory effect of PDLSCs, as well as their contribution to repair and regeneration of periodontium and other tissues are summarized.
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