Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell.
M. José Barberá,Agatha Schlüter,Neus Pedraza,Roser Iglesias,Francesc Villarroya,Marta Giralt +5 more
TLDR
It is proposed that the effects of PPARalpha activation on expression of the brown fat-specific uncoupling protein-1 (ucp-1) gene mediates ucp-1 gene up-regulation associated with adipogenic differentiation or in coordination with gene expression for the fatty acid oxidation machinery required for active thermogenesis.About:
This article is published in Journal of Biological Chemistry.The article was published on 2001-01-12 and is currently open access. It has received 332 citations till now. The article focuses on the topics: Peroxisome proliferator-activated receptor alpha & Thermogenin.read more
Citations
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Brown Adipose Tissue: Function and Physiological Significance
Barbara Cannon,Jan Nedergaard +1 more
TL;DR: The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings.
Journal ArticleDOI
PRDM16 controls a brown fat/skeletal muscle switch
Patrick Seale,Bryan C. Bjork,Wenli Yang,Shingo Kajimura,Sherry Chin,Shihuan Kuang,Anthony Scimè,Srikripa Devarakonda,Heather M. Conroe,Hediye Erdjument-Bromage,Paul Tempst,Michael A. Rudnicki,David R. Beier,Bruce M. Spiegelman +13 more
TL;DR: It is shown by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage.
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Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.
TL;DR: PGC-1 alpha constitutes one of the first and clearest examples in which biological programs are chiefly regulated by a transcriptional coactivator in response to environmental stimuli and its control of energy homeostasis suggests that it could be a target for anti-obesity or diabetes drugs.
Journal ArticleDOI
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
ffolliott M. Fisher,Sandra Kleiner,Nicholas Douris,Elliott C. Fox,Rina J. Mepani,Francisco Verdeguer,Jun Wu,Alexei Kharitonenkov,Jeffrey S. Flier,Eleftheria Maratos-Flier,Bruce M. Spiegelman +10 more
TL;DR: It is shown here that fibroblast growth factor 21 (FGF21) plays a physiologic role in this thermogenic recruitment of WATs and acts to activate and expand the thermogenic machinery in vivo to provide a robust defense against hypothermia.
Journal ArticleDOI
Peroxisome proliferator-activated receptor α target genes
TL;DR: In this article, the involvement of PPARalpha in peroxisomal and mitochondrial fatty acid oxidation, microsomal fatty acid hydroxylation, lipoprotein, bile and amino acid metabolism, glucose homeostasis, biotransformation, inflammation control, hepato-carcinogenesis and other pathways, through a detailed analysis of the different known or putative PPARα target genes.
References
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Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1
Zhidan Wu,Pere Puigserver,Ulf Andersson,Chen-Yu Zhang,Guillaume Adelmant,Vamsi K. Mootha,Amy E Troy,Saverio Cinti,Bradford B. Lowell,Richard C. Scarpulla,Bruce M. Spiegelman +10 more
TL;DR: PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation of the nuclear respiratory factors (NRFs).
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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Pere Puigserver,Zhidan Wu,Cheol Won Park,Reed A. Graves,Margaret E. Wright,Bruce M. Spiegelman +5 more
TL;DR: Results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis.
Journal ArticleDOI
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
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Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.
TL;DR: The results suggest that the physiologic role of PPAR gamma 2 is to regulate development of the adipose lineage in response to endogenous lipid activators and that this factor may serve to link the process of adipocyte differentiation to systemic lipid metabolism.
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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Isabelle Issemann,Stephen Green +1 more
TL;DR: A member of the steroid hormone receptor superfamily of ligand-activated transcription factors is cloned that is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes.