Journal ArticleDOI
Pharmaceutical Co-Crystals
Reads0
Chats0
TLDR
This review addresses how crystal engineering has been applied to active pharmaceutical ingredients, API's, with emphasis upon how pharmaceutical co-crystals, a long known but little explored alternative to the four traditionally known forms of API, can be generated in a rational fashion.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 2006-03-01. It has received 904 citations till now.read more
Citations
More filters
Journal ArticleDOI
Mechanochemistry: opportunities for new and cleaner synthesis
Stuart L. James,Christopher J. Adams,Carsten Bolm,Dario Braga,Paul Collier,Tomislav Friščić,Fabrizia Grepioni,Kenneth D. M. Harris,Geoff Hyett,William Jones,Anke Krebs,James Mack,Lucia Maini,A. Guy Orpen,Ivan P. Parkin,William C. Shearouse,Jonathan W. Steed,Daniel C. Waddell +17 more
TL;DR: Concentrating on recent advances, this article covers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical aspects, metal complexes, supramolecular aspects and characterization methods.
Journal ArticleDOI
Pharmaceutical Cocrystals and Their Physicochemical Properties
Nate Schultheiss,Ann Newman +1 more
TL;DR: The advances made over the last 10 years pertaining to physical and chemical property improvements through pharmaceutical cocrystalline materials will be highlighted and discussed to draw closer the fields of crystal engineering and pharmaceutical sciences.
Journal ArticleDOI
Strategies to Address Low Drug Solubility in Discovery and Development
Hywel David Williams,Natalie L. Trevaskis,Susan A. Charman,Ravi Mysore Shanker,William N. Charman,Colin W. Pouton,Christopher J.H. Porter +6 more
TL;DR: The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required.
Journal ArticleDOI
Drug Solubility: Importance and Enhancement Techniques
TL;DR: Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation, and so forth.
Journal ArticleDOI
Polymorphs, Salts, and Cocrystals: What’s in a Name?
Srinivasulu Aitipamula,Rahul Banerjee,Arvind K. Bansal,Kumar Biradha,Miranda L. Cheney,Angshuman Roy Choudhury,Gautam R. Desiraju,Amol G. Dikundwar,Ritesh Dubey,Naga Kiran Duggirala,Preetam P. Ghogale,Soumyajit Ghosh,Pramod Kumar Goswami,N. Rajesh Goud,Ram K. R. Jetti,Piotr H. Karpinski,Poonam Kaushik,Dinesh Kumar,Vineet Kumar,Brian Moulton,Arijit Mukherjee,Gargi Mukherjee,Allan S. Myerson,Vibha Puri,Arunachalam Ramanan,T. Rajamannar,C. Malla Reddy,Naír Rodríguez-Hornedo,Robin D. Rogers,T. N. Guru Row,Palash Sanphui,Ning Shan,Ganesh Shete,Amit Singh,Changquan Calvin Sun,Jennifer A. Swift,Ram Thaimattam,Tejender S. Thakur,Rajesh Kumar Thaper,Sajesh P. Thomas,Srinu Tothadi,Venu R. Vangala,Narayan Variankaval,Peddy Vishweshwar,David R. Weyna,Michael J. Zaworotko +45 more
TL;DR: A discussion of the FDA guidance on regulatory classification of pharmaceutical cocrystals of active pharmaceutical ingredients (APIs) was held in Manesar near Delhi, India, from February 2-4, 2012 as mentioned in this paper.
References
More filters
Journal ArticleDOI
Functional porous coordination polymers.
TL;DR: The aim is to present the state of the art chemistry and physics of and in the micropores of porous coordination polymers, and the next generation of porous functions based on dynamic crystal transformations caused by guest molecules or physical stimuli.
MonographDOI
Supramolecular Chemistry: Concepts and Perspectives
TL;DR: From molecular to supramolescular chemistry: concepts and language of supramolecular chemistry, molecular recognition, information, complementarity molecular receptors - design principles and more.
Journal ArticleDOI
From molecules to crystal engineering: supramolecular isomerism and polymorphism in network solids.
Journal ArticleDOI
Modular chemistry: secondary building units as a basis for the design of highly porous and robust metal-organic carboxylate frameworks.
Mohamed Eddaoudi,David B. Moler,Hailian Li,Banglin Chen,Theresa M. Reineke,Michael O'Keeffe,Omar M. Yaghi +6 more
TL;DR: Consideration of the geometric and chemical attributes of the SBUs and linkers leads to prediction of the framework topology, and in turn to the design and synthesis of a new class of porous materials with robust structures and high porosity.
Journal ArticleDOI
Supramolecular Synthons in Crystal Engineering—A New Organic Synthesis
TL;DR: In this article, the authors show that crystal engineering is a new organic synthesis, and that rather than being only nominally relevant to organic chemistry, this subject is well within the mainstream, being surprisingly similar to traditional organic synthesis in concept.