Phase I/II randomized trial of aerobic exercise in Parkinson disease in a community setting.
Ergun Y. Uc,Kevin C. Doerschug,Vincent A. Magnotta,Jeffrey D. Dawson,Teri Thomsen,Joel N. Kline,Matthew Rizzo,Sara Newman,Sonya Mehta,Thomas J. Grabowski,Joel Bruss,Derek R. Blanchette,Steven W. Anderson,Michelle W. Voss,Arthur F. Kramer,Warren G. Darling +15 more
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This preliminary study suggests that aerobic walking in a community setting is safe, well tolerated, and improves aerobic fitness, motor function, fatigue, mood, executive control, and quality of life in mild to moderate PD.Abstract:
Objectives: To (1) investigate effects of aerobic walking on motor function, cognition, and quality of life in Parkinson disease (PD), and (2) compare safety, tolerability, and fitness benefits of different forms of exercise intervention: continuous/moderate intensity vs interval/alternating between low and vigorous intensity, and individual/neighborhood vs group/facility setting. Methods: Initial design was a 6-month, 2 × 2 randomized trial of different exercise regimens in independently ambulatory patients with PD. All arms were required to exercise 3 times per week, 45 minutes per session. Results: Randomization to group/facility setting was not feasible because of logistical factors. Over the first 2 years, we randomized 43 participants to continuous or interval training. Because preliminary analyses suggested higher musculoskeletal adverse events in the interval group and lack of difference between training methods in improving fitness, the next 17 participants were allocated only to continuous training. Eighty-one percent of 60 participants completed the study with a mean attendance of 83.3% (95% confidence interval: 77.5%–89.0%), exercising at 46.8% (44.0%–49.7%) of their heart rate reserve. There were no serious adverse events. Across all completers, we observed improvements in maximum oxygen consumption, gait speed, Unified Parkinson9s Disease Rating Scale sections I and III scores (particularly axial functions and rigidity), fatigue, depression, quality of life (e.g., psychological outlook), and flanker task scores ( p p p Conclusions: Our preliminary study suggests that aerobic walking in a community setting is safe, well tolerated, and improves aerobic fitness, motor function, fatigue, mood, executive control, and quality of life in mild to moderate PD. Classification of evidence: This study provides Class IV evidence that in patients with PD, an aerobic exercise program improves aerobic fitness, motor function, fatigue, mood, and cognition.read more
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Diagnosis and management of dementia with Lewy bodies Fourth consensus report of the DLB Consortium
Ian G. McKeith,Bradley F. Boeve,Dennis W. Dickson,Glenda M. Halliday,John-Paul Taylor,Daniel Weintraub,Dag Aarsland,Dag Aarsland,James E. Galvin,Johannes Attems,Johannes Attems,Clive Ballard,Clive Ballard,Ashley Bayston,Ashley Bayston,Thomas G. Beach,Thomas G. Beach,Frédéric Blanc,Nicolaas Bohnen,Nicolaas Bohnen,Nicolaas Bohnen,Laura Bonanni,Laura Bonanni,Jose Bras,Jose Bras,Patrik Brundin,Patrik Brundin,David J. Burn,David J. Burn,Alice Chen-Plotkin,John E. Duda,Omar M. A. El-Agnaf,Howard Feldman,Tanis J. Ferman,Dominic Ffytche,Hiroshige Fujishiro,Douglas Galasko,Jennifer G. Goldman,Stephen N. Gomperts,Neill R. Graff-Radford,Lawrence S. Honig,Lawrence S. Honig,Alex Iranzo,Alex Iranzo,Alex Iranzo,Kejal Kantarci,Daniel I. Kaufer,Walter Kukull,Virginia M.Y. Lee,James B. Leverenz,James B. Leverenz,Simon J.G. Lewis,Carol F. Lippa,Carol F. Lippa,Angela Lunde,M Masellis,M Masellis,M Masellis,Eliezer Masliah,Pamela J. McLean,Brit Mollenhauer,Brit Mollenhauer,Thomas J. Montine,Thomas J. Montine,Emilio Moreno,Emilio Moreno,Emilio Moreno,Etsuro Mori,Etsuro Mori,Etsuro Mori,Melissa E. Murray,John T. O'Brien,John T. O'Brien,Sotoshi Orimo,Sotoshi Orimo,Ronald B. Postuma,Ronald B. Postuma,Shankar Ramaswamy,Shankar Ramaswamy,Owen A. Ross,David P. Salmon,David P. Salmon,Andrew B. Singleton,Andrew B. Singleton,Angela Taylor,Angela Taylor,Alan Thomas,Pietro Tiraboschi,Jon B. Toledo,John Q. Trojanowski,Debby W. Tsuang,Zuzana Walker,Zuzana Walker,Masahito Yamada,Masahito Yamada,Kenji Kosaka +95 more
TL;DR: The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for the last decade.
Journal ArticleDOI
International Parkinson and movement disorder society evidence‐based medicine review: Update on treatments for the motor symptoms of Parkinson's disease
Susan H. Fox,Regina Katzenschlager,Shen-Yang Lim,Brandon R. Barton,Rob M.A. de Bie,Klaus Seppi,Miguel Coelho,Cristina Sampaio +7 more
TL;DR: The objective of this review was to update evidence‐based medicine recommendations for treating motor symptoms of Parkinson's disease with new recommendations for treatment of central nervous system symptoms.
Journal ArticleDOI
Update on treatments for nonmotor symptoms of Parkinson's disease—an evidence-based medicine review
Klaus Seppi,K. Ray Chaudhuri,Miguel Coelho,Susan H. Fox,Regina Katzenschlager,Santiago Perez Lloret,Daniel Weintraub,Daniel Weintraub,Cristina Sampaio,Cristina Sampaio +9 more
TL;DR: To update evidence‐based medicine recommendations for treating nonmotor symptoms in Parkinson's disease, the World Health Organization (WHO) selected Austria as a preferred destination for research and clinical trials.
Journal ArticleDOI
Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial.
Margaret Schenkman,Charity G. Moore,Wendy M. Kohrt,Wendy M. Kohrt,Deborah A. Hall,Anthony Delitto,Cynthia L. Comella,Deborah A. Josbeno,Cory L. Christiansen,Cory L. Christiansen,Brian Berman,Benzi M. Kluger,Edward L. Melanson,Edward L. Melanson,Samay Jain,Julie A. Robichaud,Cynthia Poon,Daniel M. Corcos +17 more
TL;DR: High-intensity treadmill exercise may be feasible and prescribed safely for patients with Parkinson disease and an efficacy trial is warranted to determine whether high- intensity treadmill exercise produces meaningful clinical benefits in de novo Parkinson disease.
Journal ArticleDOI
Effectiveness of home-based and remotely supervised aerobic exercise in Parkinson's disease: a double-blind, randomised controlled trial
Nicolien M. van der Kolk,Nienke M. de Vries,Roy P. C. Kessels,Hilde Joosten,Aeilko H. Zwinderman,Bart Post,Bastiaan R. Bloem +6 more
TL;DR: The effectiveness of aerobic exercise-gamified and delivered at home, to promote adherence-on relieving motor symptoms in patients with Parkinson's disease with mild disease severity who were on common treatment regimes is evaluated.
References
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ACSM's guidelines for exercise testing and prescription
TL;DR: In this paper, the authors discuss the benefits and risks associated with physical activity and propose a general principles of exercise prescription for healthy populations with special consideration and environmental consideration, as well as a prescription for patients with chronic diseases and health conditions.
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Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association.
William L. Haskell,I-Min Lee,Russell R. Pate,Kenneth E. Powell,Steven N. Blair,Barry A. Franklin,Caroline A. Macera,Gregory W. Heath,Paul D. Thompson,Adrian Bauman +9 more
TL;DR: The purpose of the present report is to update and clarify the 1995 recommendations on the types and amounts of physical activity needed by healthy adults to improve and maintain health.
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Systematic review of levodopa dose equivalency reporting in Parkinson's disease
TL;DR: A systematic review of studies reporting LEDs yielded a standardized LED for each drug, providing a useful tool to express dose intensity of different antiparkinsonian drug regimens on a single scale.
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Superior Cardiovascular Effect of Aerobic Interval Training Versus Moderate Continuous Training in Heart Failure Patients A Randomized Study
Ulrik Wisløff,Asbjørn Støylen,Jan Pål Loennechen,Morten Bruvold,Øivind Rognmo,Per Magnus Haram,Arnt Erik Tjønna,Jan Helgerud,Stig A. Slørdahl,Sang Jun Lee,Vibeke Videm,Anja Bye,Godfrey L. Smith,Sonia M. Najjar,Øyvind Ellingsen,Terje Skjærpe +15 more
TL;DR: Exercise intensity was an important factor for reversing LV remodeling and improving aerobic capacity, endothelial function, and quality of life in patients with postinfarction heart failure.
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