Phosphoregulation of the autophagy machinery by kinases and phosphatases.
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TLDR
In this paper, the authors summarize the current knowledge on kinases and phosphatases acting on the core autophagy machinery and discuss the relevance of phosphoregulation for the overall process of autophagocytosis.Abstract:
Eukaryotic cells use post-translational modifications to diversify and dynamically coordinate the function and properties of protein networks within various cellular processes. For example, the process of autophagy strongly depends on the balanced action of kinases and phosphatases. Highly conserved from the budding yeast Saccharomyces cerevisiae to humans, autophagy is a tightly regulated self-degradation process that is crucial for survival, stress adaptation, maintenance of cellular and organismal homeostasis, and cell differentiation and development. Many studies have emphasized the importance of kinases and phosphatases in the regulation of autophagy and identified many of the core autophagy proteins as their direct targets. In this review, we summarize the current knowledge on kinases and phosphatases acting on the core autophagy machinery and discuss the relevance of phosphoregulation for the overall process of autophagy.read more
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References
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Journal ArticleDOI
Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy.
Changqian Zhou,Kaili Ma,Ruize Gao,Chenglong Mu,Linbo Chen,Qiangqiang Liu,Qian Luo,Du Feng,Yushan Zhu,Quan Chen,Quan Chen +10 more
TL;DR: Two conserved classic adaptor protein sorting signals within the cytosolic N-terminus of m ATG9 mediate trafficking of mATG9 from the plasma membrane and trans-Golgi network (TGN) via interaction with the AP1/2 complex, and suggest a coordination of basal and stress-induced autophagy.
Journal ArticleDOI
Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress
Aditi U. Gurkar,Kiki Chu,Lakshmi Raj,Richard Bouley,Seung-Hwan Lee,Young-Bum Kim,Sandra E. Dunn,Anna Mandinova,Anna Mandinova,Sam W. Lee,Sam W. Lee +10 more
TL;DR: Results show that ROCK1 acts as a prominent upstream regulator of Beclin1-mediated autophagy and maintains a homeostatic balance between apoptosis andAutophagy.
Journal ArticleDOI
Yeast phosphatidylinositol 4-kinase, Pik1, has essential roles at the Golgi and in the nucleus.
TL;DR: Catalytically inactive derivatives of these compartment-restricted Pik1 constructs indicated that PtdIns4P must be generated both in the nucleus and at the Golgi for normal cell function.
Journal ArticleDOI
Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p.
Huijun Wei,Danita G. Ashby,Carlos S. Moreno,Egon Ogris,Foong May Yeong,Anita H. Corbett,David C. Pallas +6 more
TL;DR: The results indicate that methylation and phosphorylation may be mechanisms by which the cell dynamically regulates PP2A complex formation and function.
Journal ArticleDOI
Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation
TL;DR: An overview of the known post-translational modifications of Beclin 1 that govern its role in autophagy and how these modifications are maintained by input from several upstream signalling pathways is provided.
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