Phosphoregulation of the autophagy machinery by kinases and phosphatases.
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In this paper, the authors summarize the current knowledge on kinases and phosphatases acting on the core autophagy machinery and discuss the relevance of phosphoregulation for the overall process of autophagocytosis.Abstract:
Eukaryotic cells use post-translational modifications to diversify and dynamically coordinate the function and properties of protein networks within various cellular processes. For example, the process of autophagy strongly depends on the balanced action of kinases and phosphatases. Highly conserved from the budding yeast Saccharomyces cerevisiae to humans, autophagy is a tightly regulated self-degradation process that is crucial for survival, stress adaptation, maintenance of cellular and organismal homeostasis, and cell differentiation and development. Many studies have emphasized the importance of kinases and phosphatases in the regulation of autophagy and identified many of the core autophagy proteins as their direct targets. In this review, we summarize the current knowledge on kinases and phosphatases acting on the core autophagy machinery and discuss the relevance of phosphoregulation for the overall process of autophagy.read more
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References
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The Structure of the Cell Cycle Protein Cdc14 Reveals a Proline-Directed Protein Phosphatase
TL;DR: Structural and kinetic data support a role for Cdc14 in the preferential dephosphorylation of proteins modified by proline‐directed kinases.
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AMPK regulates autophagy by phosphorylating BECN1 at threonine 388
Deyi Zhang,Wei Wang,Xiujie Sun,Daqian Xu,Chenyao Wang,Qian Zhang,Huafei Wang,Wenwen Luo,Yan Chen,Huaiyong Chen,Zhixue Liu +10 more
TL;DR: It is shown that AMP-activated protein kinase (AMPK) regulates autophagy by phosphorylating BECN1 at Thr388, uncovering a novel mechanism of Autophagy regulation.
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