Journal ArticleDOI
Photo-activated chemo-immunotherapy for metastatic cancer using a synergistic graphene nanosystem
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TLDR
It is demonstrated that rGO/MTX/SB combined with laser irradiation provided a synergistic chemo-immuno-photothermal effect against tumors by in situ vaccination and inhibition of immunosuppressive microenvironment.About:
This article is published in Biomaterials.The article was published on 2021-01-01. It has received 70 citations till now. The article focuses on the topics: Tumor microenvironment & Immunotherapy.read more
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Nanomaterials for cancer therapy: current progress and perspectives.
TL;DR: Nanomaterials are materials in the nanorange 1-100nm which possess unique optical, magnetic, and electrical properties as discussed by the authors, and they have been modified for a wide range of cancer therapies to overcome toxicity and lack of specificity.
Journal ArticleDOI
Graphene and its derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications
Tais Monteiro Magne,Thamires de Oliveira Vieira,Luciana Magalhães Rebelo Alencar,Francisco Franciné Maia Junior,Sara Gemini-Piperni,Samuel Veloso Carneiro,Lillian Maria Uchoa Dutra Fechine,Rafael M. Freire,Kirill S. Golokhvast,Pierangelo Metrangolo,Pierre Basílio Almeida Fechine,Ralph Santos-Oliveira +11 more
TL;DR: In this article, the applicability of the graphene family in several biomedical modalities, with particular attention for cancer therapy and diagnosis, as a potent theranostic, is discussed, focusing on its synthesis methodology, physicochemical properties, and production quality.
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Smart nanomaterials for cancer diagnosis and treatment
TL;DR: In this article , a review of smart nanomaterial-based cancer theranostic approaches have been developed, and they are displaying better selectivity and sensitivity with reduced side-effects in comparison to conventional methods.
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Engineered nanomaterials for synergistic photo-immunotherapy.
TL;DR: Wang et al. as discussed by the authors investigated the latest strategies on engineering nanomaterials to enhance the anti-cancer efficiency of synergistic photo-immunotherapy, with emphasis on the activation of anti-tumor immune response, the reversal of tumor immunosuppressive microenvironment (TIME), the regulation of the interaction between immunosensressive cells and tumor cells, the infiltration of immune cells and improved efficiency of photo-IMmunotherapy-induced ICD.
Journal ArticleDOI
Multifunctional inorganic nanomaterials for cancer photoimmunotherapy
TL;DR: In this review, the recent advances of multifunctional inorganic nanomaterial‐mediated drug delivery and their contributions to cancer PIT will be highlighted.
References
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The future of immune checkpoint therapy
Padmanee Sharma,James P. Allison +1 more
TL;DR: The way forward for this class of novel agents lies in the ability to understand human immune responses in the tumor microenvironment, which will provide valuable information regarding the dynamic nature of the immune response and regulation of additional pathways that will need to be targeted through combination therapies to provide survival benefit for greater numbers of patients.
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TGFβ in Cancer
TL;DR: The mechanistic basis and clinical relevance of TGFbeta's role in cancer is becoming increasingly clear, paving the way for a better understanding of the complexity and therapeutic potential of this pathway.
Journal ArticleDOI
Calreticulin exposure dictates the immunogenicity of cancer cell death
Michel Obeid,Antoine Tesniere,Antoine Tesniere,Antoine Tesniere,François Ghiringhelli,François Ghiringhelli,François Ghiringhelli,Gian Maria Fimia,Lionel Apetoh,Lionel Apetoh,Lionel Apetoh,Jean-Luc Perfettini,Jean-Luc Perfettini,Jean-Luc Perfettini,Maria Castedo,Maria Castedo,Maria Castedo,Grégoire Mignot,Grégoire Mignot,Grégoire Mignot,Theoharis Panaretakis,Theoharis Panaretakis,Theoharis Panaretakis,Noelia Casares,Noelia Casares,Noelia Casares,Didier Métivier,Didier Métivier,Didier Métivier,Nathanael Larochette,Nathanael Larochette,Nathanael Larochette,Peter van Endert,Peter van Endert,Fabiola Ciccosanti,Mauro Piacentini,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel,Guido Kroemer,Guido Kroemer,Guido Kroemer +41 more
TL;DR: It is shown that anthracyclin-induced CRT translocation induces the rapid, preapoptotic translocation of calreticulin (CRT) to the cell surface and is identified as a key feature determining anticancer immune responses.
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Immunogenic Cell Death in Cancer Therapy
TL;DR: It is postulate that ICD constitutes a prominent pathway for the activation of the immune system against cancer, which in turn determines the long-term success of anticancer therapies and its subversion by pathogens.
Journal ArticleDOI
Breast Cancer Treatment: A Review.
Adrienne G. Waks,Eric P. Winer +1 more
TL;DR: This review focuses on current approaches and evolving strategies for local and systemic therapy of breast cancer as well as distinct risk profiles and treatment strategies.