Journal ArticleDOI
Physical activity and risk of breast cancer: a meta-analysis of prospective studies.
Yili Wu,Dongfeng Zhang,Shan Kang +2 more
TLDR
A meta-analysis to summarize the evidence from prospective studies regarding the association between physical activity and breast cancer risk suggested that physical activity could significantly reduce the risk of breast cancer.Abstract:
We conducted a meta-analysis to summarize the evidence from prospective studies regarding the association between physical activity and breast cancer risk. A comprehensive search was conducted to identify eligible studies. The fixed or random effect model was used based on heterogeneity test. The dose–response relationship was assessed by restricted cubic spline model and multivariate random-effect meta-regression. Overall, 31 studies with 63,786 cases were included, and the combined relative risk (RR) with 95 % CI of breast cancer was 0.88 (0.85–0.91). In subgroup analysis by activity type, data from 27 studies including 37,568 cases for non-occupational activity (including recreational activity and household activity) and seven studies including 28,268 cases for occupational activity were used, and the RR (95 % CI) of breast cancer was 0.87 (0.83–0.91) and 0.90 (0.83–0.97), respectively. The inverse association was consistent among all subgroups analyses. Stronger association was found for subjects with BMI <25 kg/m2 [0.72 (0.65–0.81)], premenopausal women [0.77 (0.72–0.84)], and estrogen and progesterone receptor-negative breast cancer [0.80 (0.73–0.87)]. Dose–response analysis suggested that the risk of breast cancer decreased by 2 % (P < 0.00) for every 25 metabolic equivalent (MET)-h/week increment in non-occupational physical activity, 3 % (P < 0.00) for every 10 MET-h/week (roughly equivalent to 4 h/week of walking in 2 miles/h or 1 h/week of running in 6 miles/h) increment in recreational activity, and 5 % (P < 0.00) for every 2 h/week increment in moderate plus vigorous recreational activity, respectively. Physical activity could significantly reduce the risk of breast cancer.read more
Citations
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Journal ArticleDOI
Breast cancer statistics, 2013
TL;DR: An overview of female breast cancer statistics in the United States, including data on incidence, mortality, survival, and screening is provided, with African American women having the poorest breast cancer survival of any racial/ethnic group.
Journal ArticleDOI
Shared Risk Factors in Cardiovascular Disease and Cancer
TL;DR: This review explores the risk factors common to both CVD and cancer, highlighting the major epidemiological studies and potential biological mechanisms that account for them.
Journal ArticleDOI
Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013
Hmwe H Kyu,Victoria F Bachman,Lily Alexander,John Everett Mumford,Ashkan Afshin,Kara Estep,J. Lennert Veerman,Kristen Delwiche,Marissa Iannarone,Madeline L Moyer,Kelly Cercy,Theo Vos,Christopher J L Murray,Mohammad H. Forouzanfar +13 more
TL;DR: People who achieve total physical activity levels several times higher than the current recommended minimum level have a significant reduction in the risk of the five diseases studied.
Journal ArticleDOI
Adipose tissue and adipocytes support tumorigenesis and metastasis.
TL;DR: Given that adipocytes are a major source of adipokines and energy for the cancer cell, understanding the mechanisms of metabolic symbiosis between cancer cells and adipocytes, should reveal new therapeutic possibilities.
Journal ArticleDOI
American College of Sports Medicine Roundtable Report on Physical Activity, Sedentary Behavior, and Cancer Prevention and Control.
Alpa V. Patel,Christine M. Friedenreich,Steven C. Moore,Sandra C. Hayes,Julie K. Silver,Kristin L. Campbell,Kerri M. Winters-Stone,Lynn H. Gerber,Stephanie M. George,Janet E. Fulton,Crystal S. Denlinger,G. Stephen Morris,Trisha F. Hue,Kathryn H. Schmitz,Charles E. Matthews +14 more
TL;DR: There is consistent, compelling evidence that physical activity plays a role in preventing many types of cancer and for improving longevity among cancer survivors, although the evidence related to higher risk of melanoma demonstrates the importance of sun safe practices while being physically active.
References
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Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
Journal ArticleDOI
Compendium of physical activities: an update of activity codes and MET intensities.
Barbara E. Ainsworth,William L. Haskell,Melicia C. Whitt,Melinda L. Irwin,A. M. Swartz,Scott J. Strath,O'Brien Wl,David R. Bassett,Kathryn H. Schmitz,Patricia O. Emplaincourt,David R. Jacobs,Arthur S. Leon +11 more
TL;DR: An updated version of the Compendium of Physical Activities, a coding scheme that classifies specific physical activity (PA) by rate of energy expenditure, is provided to enhance the comparability of results across studies using self-reports of PA.
Journal ArticleDOI
Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy
TL;DR: In this article, the authors quantify the effect of physical inactivity on these major non-communicable diseases by estimating how much disease could be averted if inactive people were to become active and to estimate gain in life expectancy at the population level.
Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy
TL;DR: In this article, the authors quantify the effect of physical inactivity on these major non-communicable diseases by estimating how much disease could be averted if inactive people were to become active and to estimate gain in life expectancy at the population level.
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