Adipose tissue and adipocytes support tumorigenesis and metastasis.
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TLDR
Given that adipocytes are a major source of adipokines and energy for the cancer cell, understanding the mechanisms of metabolic symbiosis between cancer cells and adipocytes, should reveal new therapeutic possibilities.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-10-01 and is currently open access. It has received 576 citations till now. The article focuses on the topics: Adipose tissue macrophages & Adipose tissue.read more
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Epidemiology of esophageal cancer.
TL;DR: The epidemiologic patterns and causes of EsC are investigated using population based cancer data from the Surveillance, Epidemiology and End Results Program of the United States and the most up-to-date stage distribution and 5-year relative survival by stage at diagnosis for 1998-2009 are generated.
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Reprogramming of fatty acid metabolism in cancer
TL;DR: This review will examine the mechanisms through which cancer cells rewire their fatty acid metabolism with a focus on four main areas of research, including the role of de novo synthesis and exogenous uptake in the cellular pool of fatty acids.
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Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities
TL;DR: Tumor markers of esophageal cancer are an advancing area of research that could potentially lead to earlier diagnosis as well as playing a part in assessing tumor response to therapy.
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Obesity and cancer—mechanisms underlying tumour progression and recurrence
TL;DR: Recent advances in understanding the contributions of obesity to cancer and their implications for tumour treatment are discussed.
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Obesity, Inflammation, and Cancer
TL;DR: How adipose tissue becomes inflamed in obesity is described, ways these mechanisms impact cancer development are summarized, and their role in four adipose-associated cancers that demonstrate elevated incidence or mortality in obesity are discussed.
References
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Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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Obesity is associated with macrophage accumulation in adipose tissue
Stuart P. Weisberg,Daniel McCann,Manisha Desai,Michael Rosenbaum,Rudolph L. Leibel,Anthony W. Ferrante +5 more
TL;DR: Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
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Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.
TL;DR: Current patterns of overweight and obesity in the United States could account for 14 percent of all deaths from cancer in men and 20 percent of those in women, and increased body weight was associated with increased death rates for all cancers combined and for cancers at multiple specific sites.
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Mortality in relation to smoking: 50 years' observations on male British doctors
TL;DR: In this article, the British Medical Association forwarded to all British doctors a questionnaire about their smoking habits, and 34440 men replied, with few exceptions, all men who replied in 1951 have been followed for 20 years.