Journal ArticleDOI
Physicochemical and pathophysiological factors in the release of membrane-bound alkaline phosphatase from cells.
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TLDR
The structure of this domain and ways in which it may be cleaved by chemical and enzymatic means provide a basis for understanding the solubilization of alkaline phosphatase from tissues in vitro and in vivo and the generation of isoforms.About:
This article is published in Clinica Chimica Acta.The article was published on 1997-01-03. It has received 48 citations till now. The article focuses on the topics: Alkaline phosphatase & Acid phosphatase.read more
Citations
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Journal ArticleDOI
Liver enzyme alteration: a guide for clinicians
TL;DR: In this review, a schematic approach is used that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, and abnormal enzymatic activity within the 2 subgroups are reviewed.
Journal ArticleDOI
Diagnosis and Monitoring of Hepatic Injury. I. Performance Characteristics of Laboratory Tests
D. Robert Dufour,John A. Lott,Frederick S. Nolte,David R. Gretch,Raymond S. Koff,Leonard B. Seeff +5 more
TL;DR: The international normalized ratio should not be the sole method for reporting results of prothrombin time in liver disease; additional research is needed to determine the reporting mechanism that best correlates with functional impairment.
Journal ArticleDOI
Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers.
Kwangsik Nho,Alexandra Kueider-Paisley,Shahzad Ahmad,Siamak MahmoudianDehkordi,Matthias Arnold,Shannon L. Risacher,Gregory Louie,Colette Blach,Rebecca Baillie,Xianlin Han,Gabi Kastenmüller,John Q. Trojanowski,Leslie M. Shaw,Michael W. Weiner,P. Murali Doraiswamy,Cornelia M. van Duijn,Cornelia M. van Duijn,Andrew J. Saykin,Rima Kaddurah-Daouk +18 more
TL;DR: In this paper, the authors examined whether liver function markers are associated with cognitive dysfunction and the A/T/N (amyloid, tau, and neurodegeneration) biomarkers for AD.
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Alkaline phosphatase is increased in both brain and plasma in Alzheimer's disease.
TL;DR: The data indicate that TNAP is increased in both sporadic and familial AD but not in the aged brain, indicating that the increase is likely a consequence of AD-associated changes in the brain.
References
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Journal ArticleDOI
Cell-Surface Anchoring of Proteins via Glycosyl-Phosphatidylinositol Structures
TL;DR: A class of membrane molecules has been identified whose primary translation product includes a COOH-terminal protein sequence that signals attachment of a glycosyl-phosphatidylinositol anchor at a COPD residue that is newly formed by cleavage of the signaling sequence.
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Structural and Functional Roles of Glycosyl-Phosphatidylinositol in Membranes
Martin G. Low,Alan R. Saltiel +1 more
TL;DR: Glycosylated forms of phosphatidylinositol, which have only recently been described in eukaryotic organisms, are now known to play important roles in biological membrane function and may also be involved in signal transduction mechanisms for the hormone insulin.
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Glycolipid anchoring of plasma membrane proteins
TL;DR: Serological Cross-Reactions and Indications of a Glycolipid Anchor and the Hydrophobic Constituents are studied.
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Molecular cloning and sequence analysis of human placental alkaline phosphatase.
TL;DR: The complete amino acid sequence of the precursor and mature forms of human placental alkaline phosphatase have been inferred from analysis of a cDNA.
Journal ArticleDOI
A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma.
Martin G. Low,A. R. S. Prasad +1 more
TL;DR: The findings indicate that this anchor-degrading activity could play an important role in regulating the expression and release of cell-surface proteins in vivo and is due to a phospholipase D with specificity for glycosyl-phosphatidylinositol structures.
Related Papers (5)
Studies on the mechanism of the increase in serum alkaline phosphatase activity in cholestasis: significance of the hepatic bile acid concentration for the leakage of alkaline phosphatase from rat liver.
Schlaeger R,Haux P,Kattermann R +2 more