Physical and neurobehavioral determinants of reproductive onset and success
Felix R. Day,Hannes Helgason,Hannes Helgason,Daniel I. Chasman,Daniel I. Chasman,Lynda M. Rose,Po-Ru Loh,Po-Ru Loh,Robert A. Scott,Agnar Helgason,Agnar Helgason,Augustine Kong,Augustine Kong,Gisli Masson,Olafur Th Magnusson,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Julie E. Buring,Julie E. Buring,Paul M. Ridker,Paul M. Ridker,Patrick Sulem,Kari Stefansson,Kari Stefansson,Ken K. Ong,John R. B. Perry +27 more
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TLDR
The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behavior and success, respectively and Mendelian randomization analyses infer causal influences of earlier puberty timing on earlier firstSexual intercourse, earlier first birth and lower educational attainment.Abstract:
The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behavior and success, respectively. In a genome-wide association study of 125,667 UK Biobank participants, we identify 38 loci associated (P < 5 × 10(-8)) with age at first sexual intercourse. These findings were taken forward in 241,910 men and women from Iceland and 20,187 women from the Women's Genome Health Study. Several of the identified loci also exhibit associations (P < 5 × 10(-8)) with other reproductive and behavioral traits, including age at first birth (variants in or near ESR1 and RBM6-SEMA3F), number of children (CADM2 and ESR1), irritable temperament (MSRA) and risk-taking propensity (CADM2). Mendelian randomization analyses infer causal influences of earlier puberty timing on earlier first sexual intercourse, earlier first birth and lower educational attainment. In turn, likely causal consequences of earlier first sexual intercourse include reproductive, educational, psychiatric and cardiometabolic outcomes.read more
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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Richard Karlsson Linnér,Richard Karlsson Linnér,Pietro Biroli,Edward Kong,S. Fleur W. Meddens,S. Fleur W. Meddens,Robbee Wedow,Mark Alan Fontana,Mark Alan Fontana,Maël Lebreton,Stephen P. Tino,Abdel Abdellaoui,Anke R. Hammerschlag,Michel G. Nivard,Aysu Okbay,Cornelius A. Rietveld,Pascal Timshel,Pascal Timshel,Maciej Trzaskowski,Ronald de Vlaming,Ronald de Vlaming,Christian L. Zund,Yanchun Bao,Laura Buzdugan,Laura Buzdugan,Ann H. Caplin,Chia-Yen Chen,Chia-Yen Chen,Peter Eibich,Peter Eibich,Peter Eibich,Pierre Fontanillas,Juan R. González,Peter K. Joshi,Ville Karhunen,Aaron Kleinman,Remy Z. Levin,Christina M. Lill,Gerardus A. Meddens,Gerard Muntané,Gerard Muntané,Sandra Sanchez-Roige,Frank J. A. van Rooij,Erdogan Taskesen,Yang Wu,Futao Zhang,Adam Auton,Jason D. Boardman,David W. Clark,Andrew Conlin,Conor C. Dolan,Urs Fischbacher,Patrick J. F. Groenen,Kathleen Mullan Harris,Gregor Hasler,Albert Hofman,Albert Hofman,Mohammad Arfan Ikram,Sonia Jain,Robert Karlsson,Ronald C. Kessler,Maarten Kooyman,James MacKillop,James MacKillop,Minna Männikkö,Carlos Morcillo-Suarez,Matthew B. McQueen,Klaus M. Schmidt,Melissa C. Smart,Matthias Sutter,Matthias Sutter,Matthias Sutter,Roy Thurik,André G. Uitterlinden,Jon White,Harriet de Wit,Jian Yang,Lars Bertram,Lars Bertram,Dorret I. Boomsma,Tõnu Esko,Ernst Fehr,David A. Hinds,Magnus Johannesson,Meena Kumari,David Laibson,Patrik K. E. Magnusson,Michelle N. Meyer,Arcadi Navarro,Arcadi Navarro,Abraham A. Palmer,Tune H. Pers,Tune H. Pers,Danielle Posthuma,Daniel Schunk,Murray B. Stein,Rauli Svento,Henning Tiemeier,Paul R. H. J. Timmers,Patrick Turley,Patrick Turley,Patrick Turley,Robert J. Ursano,Gert G. Wagner,Gert G. Wagner,James F. Wilson,James F. Wilson,Jacob Gratten,Jacob Gratten,James J. Lee,David Cesarini,Daniel J. Benjamin,Daniel J. Benjamin,Philipp Koellinger,Philipp Koellinger,Jonathan P. Beauchamp +115 more
TL;DR: This paper found evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of their other GWAS, and general risk-tolerance is genetically correlated with a range of risky behaviors.
Journal ArticleDOI
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia
Joëlle A. Pasman,Karin J. H. Verweij,Karin J. H. Verweij,Zachary Gerring,Sven Stringer,Sandra Sanchez-Roige,Jorien L. Treur,Abdel Abdellaoui,Michel G. Nivard,Bart M. L. Baselmans,Jue-Sheng Ong,Hill F. Ip,Matthijs D. van der Zee,Meike Bartels,Felix R. Day,Pierre Fontanillas,Sarah L. Elson,Harriet de Wit,Lea K. Davis,James MacKillop,Jaime Derringer,Susan Branje,Catharina A. Hartman,Andrew C. Heath,Pol A. C. van Lier,Pamela A. F. Madden,Reedik Mägi,Wim Meeus,Grant W. Montgomery,Albertine J. Oldehinkel,Zdenka Pausova,Josep Antoni Ramos-Quiroga,Tomáš Paus,Marta Ribasés,Marta Ribasés,Jaakko Kaprio,Marco P. Boks,Jordana T. Bell,Tim D. Spector,Joel Gelernter,Dorret I. Boomsma,Nicholas G. Martin,Stuart MacGregor,John R. B. Perry,Abraham A. Palmer,Danielle Posthuma,Marcus R. Munafò,Nathan A. Gillespie,Nathan A. Gillespie,Eske M. Derks,Jacqueline M. Vink +50 more
TL;DR: A GWAS of lifetime cannabis use reveals new risk loci, shows that cannabis use has genetic overlap with smoking and alcohol use, and indicates that the likelihood of initiating cannabis use is causally influenced by schizophrenia.
Journal ArticleDOI
Genetic architecture: The shape of the genetic contribution to human traits and disease
TL;DR: The types of genetic architecture that have been observed, how architecture can be measured and why an improved understanding of genetic Architecture is central to future advances in the field are described.
Journal ArticleDOI
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).
Toni-Kim Clarke,Mark Adams,Gail Davies,David M. Howard,Lynsey S. Hall,Sandosh Padmanabhan,Alison D. Murray,Blair H. Smith,Archibald Campbell,Caroline Hayward,David J. Porteous,Ian J. Deary,Andrew M. McIntosh,Andrew M. McIntosh +13 more
TL;DR: This study replicates the association between alcohol consumption and alcohol metabolizing genes and KLB, and identifies novel gene associations that should be the focus of future studies investigating the neurobiology of alcohol consumption.
Journal ArticleDOI
Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Nicola Barban,Rick Jansen,Ronald de Vlaming,Ahmad Vaez,Ahmad Vaez,Jornt J. Mandemakers,Felix C. Tropf,Xia Shen,Xia Shen,James F. Wilson,Daniel I. Chasman,Ilja M. Nolte,Vinicius Tragante,Sander W. van der Laan,John R. B. Perry,Augustine Kong,Augustine Kong,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Eva Albrecht,Laura M. Yerges-Armstrong,Gil Atzmon,Gil Atzmon,Kirsi Auro,Kirsi Auro,Kristin L. Ayers,Andrew Bakshi,Danny Ben-Avraham,Klaus Berger,Aviv Bergman,Lars Bertram,Lars Bertram,Lawrence F. Bielak,Gyda Bjornsdottir,Marc Jan Bonder,Linda Broer,Minh Bui,Caterina Barbieri,Alana Cavadino,Alana Cavadino,Jorge E. Chavarro,Constance Turman,Maria Pina Concas,Heather J. Cordell,Gail Davies,Peter Eibich,Nicholas Eriksson,Tõnu Esko,Joel Eriksson,Fahimeh Falahi,Janine F. Felix,Mark Alan Fontana,Lude Franke,Ilaria Gandin,Audrey J. Gaskins,Christian Gieger,Erica P. Gunderson,Xiuqing Guo,Caroline Hayward,Chunyan He,Edith Hofer,Hongyan Huang,Peter K. Joshi,Stavroula Kanoni,Robert Karlsson,Stefan Kiechl,Annette Kifley,Alexander Kluttig,Peter Kraft,Vasiliki Lagou,Vasiliki Lagou,Cecile Lecoeur,Jari Lahti,Ruifang Li-Gao,Penelope A. Lind,Tian Liu,Enes Makalic,Crysovalanto Mamasoula,Lindsay K. Matteson,Hamdi Mbarek,Patrick F. McArdle,George McMahon,S. Fleur W. Meddens,S. Fleur W. Meddens,Evelin Mihailov,Michael B. Miller,Stacey A. Missmer,Claire Monnereau,Peter J. van der Most,Ronny Myhre,Mike A. Nalls,Teresa Nutile,Ioanna P. Kalafati,Eleonora Porcu,Inga Prokopenko,Inga Prokopenko,Kumar B. Rajan,Janet W. Rich-Edwards,Cornelius A. Rietveld,Antonietta Robino,Lynda M. Rose,Rico Rueedi,Rico Rueedi,Kathleen A. Ryan,Yasaman Saba,Daniel F. Schmidt,Jennifer A. Smith,Lisette Stolk,Elizabeth A. Streeten,Anke Tönjes,Gudmar Thorleifsson,Sheila Ulivi,Juho Wedenoja,Juergen Wellmann,Peter Willeit,Jie Yao,Loic Yengo,Jing Hua Zhao,Wei Zhao,Daria V. Zhernakova,Najaf Amin,Howard Andrews,Beverley Balkau,Nir Barzilai,Sven Bergmann,Sven Bergmann,Ginevra Biino,Hans Bisgaard,Klaus Bønnelykke,Dorret I. Boomsma,Julie E. Buring,Harry Campbell,Stefania Cappellani,Marina Ciullo,Simon R. Cox,Francesco Cucca,Daniela Toniolo,George Davey-Smith,Ian J. Deary,George Dedoussis,Panos Deloukas,Panos Deloukas,Cornelia M. van Duijn,Eco J. C. de Geus,Johan G. Eriksson,Denis A. Evans,Jessica D. Faul,Cinzia Sala,Philippe Froguel,Paolo Gasparini,Giorgia Girotto,Hans J. Grabe,Karin Halina Greiser,Patrick J. F. Groenen,Hugoline G. de Haan,Johannes Haerting,Tamara B. Harris,Andrew C. Heath,Kauko Heikkilä,Albert Hofman,Albert Hofman,Georg Homuth,Elizabeth G. Holliday,John L. Hopper,Elina Hyppönen,Elina Hyppönen,Bo Jacobsson,Bo Jacobsson,Vincent W. V. Jaddoe,Magnus Johannesson,Astanand Jugessur,Mika Kähönen,Eero Kajantie,Eero Kajantie,Eero Kajantie,Sharon L.R. Kardia,Bernard Keavney,Bernard Keavney,Ivana Kolcic,P Koponen,Peter Kovacs,Florian Kronenberg,Zoltán Kutalik,Zoltán Kutalik,Martina La Bianca,Genevieve Lachance,William G. Iacono,Sandra Lai,Terho Lehtimäki,David C. Liewald,Cecilia M. Lindgren,Yongmei Liu,Robert Luben,Michael Lucht,Riitta Luoto,Per Magnus,Patrik K. E. Magnusson,Nicholas G. Martin,Matt McGue,Matt McGue,Ruth McQuillan,Sarah E. Medland,Christa Meisinger,Dan Mellström,Andres Metspalu,Andres Metspalu,Michela Traglia,Lili Milani,Paul Mitchell,Grant W. Montgomery,Grant W. Montgomery,Dennis O. Mook-Kanamori,Dennis O. Mook-Kanamori,Renée de Mutsert,Ellen A. Nohr,Claes Ohlsson,Jørn Olsen,Ken K. Ong,Lavinia Paternoster,Alison Pattie,Brenda W.J.H. Penninx,Markus Perola,Markus Perola,Markus Perola,Patricia A. Peyser,Mario Pirastu,Ozren Polasek,Chris Power,Jaakko Kaprio,Jaakko Kaprio,Leslie J. Raffel,Katri Räikkönen,Olli T. Raitakari,Paul M. Ridker,Susan M. Ring,Kathryn Roll,Igor Rudan,Daniela Ruggiero,Dan Rujescu,Veikko Salomaa,David Schlessinger,Helena Schmidt,Reinhold Schmidt,Nicole Schupf,Johannes W. A. Smit,Rossella Sorice,Tim D. Spector,John M. Starr,Doris Stöckl,Konstantin Strauch,Michael Stumvoll,Morris A. Swertz,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Roy Thurik,Nicholas J. Timpson,Joyce Y. Tung,André G. Uitterlinden,Simona Vaccargiu,J. Viikari,Veronique Vitart,Henry Völzke,Peter Vollenweider,Dragana Vuckovic,Johannes Waage,Gert G. Wagner,Jie Jin Wang,Nicholas J. Wareham,David R. Weir,Gonneke Willemsen,Johann Willeit,Alan F. Wright,Krina T. Zondervan,Kari Stefansson,Kari Stefansson,Robert F. Krueger,James J. Lee,Daniel J. Benjamin,Daniel J. Benjamin,David Cesarini,Philipp Koellinger,Philipp Koellinger,Marcel den Hoed,Harold Snieder,Melinda Mills +284 more
TL;DR: In this article, the authors reported a large genome-wide association study of both sexes including 251,151 individuals for AB and 343,072 individuals for NEB and identified 12 independent loci that are significantly associated with AB and NEB.
References
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TL;DR: The UK Biobank is described, a large population-based prospective study, established to allow investigation of the genetic and non-genetic determinants of the diseases of middle and old age.
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Genetic studies of body mass index yield new insights for obesity biology
Glgc,Icbp,Magic Investigators +2 more
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Journal ArticleDOI
An atlas of genetic correlations across human diseases and traits.
Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,Hilary K. Finucane,Verneri Anttila,Verneri Anttila,Alexander Gusev,Felix R. Day,Po-Ru Loh,Po-Ru Loh,Laramie E. Duncan,Laramie E. Duncan,John R. B. Perry,Nick Patterson,Elise B. Robinson,Elise B. Robinson,Mark J. Daly,Mark J. Daly,Alkes L. Price,Alkes L. Price,Benjamin M. Neale,Benjamin M. Neale +20 more
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Stephan Ripke,Stephan Ripke,Benjamin M. Neale,Benjamin M. Neale,Aiden Corvin,James T.R. Walters,Kai-How Farh,Peter Holmans,Phil Lee,Phil Lee,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,David A. Collier,David A. Collier,Hailiang Huang,Hailiang Huang,Tune H. Pers,Tune H. Pers,Tune H. Pers,Ingrid Agartz,Ingrid Agartz,Esben Agerbo,Esben Agerbo,Margot Albus,Madeline Alexander,Farooq Amin,Silviu Alin Bacanu,Martin Begemann,Richard A. Belliveau,Judit Bene,Sarah E. Bergen,Sarah E. Bergen,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,William Byerley,Wiepke Cahn,Guiqing Cai,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberly Chambert,Raymond C.K. Chan,Ronald Y.L. Chen,Eric Y.H. Chen,Wei Cheng,Eric F.C. Cheung,Siow Ann Chong,C. Robert Cloninger,David Cohen,Nadine Cohen,Paul Cormican,Nicholas John Craddock,James J. Crowley,David Curtis,David Curtis,Michael Davidson,Kenneth L. Davis,Franziska Degenhardt,Jurgen Del Favero,Ditte Demontis,Ditte Demontis,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Gary Donohoe,Gary Donohoe,Elodie Drapeau,Jubao Duan,Frank Dudbridge,Naser Durmishi,Peter Eichhammer,Johan G. Eriksson,Johan G. Eriksson,Valentina Escott-Price,Laurent Essioux,Ayman H. Fanous,Martilias S. Farrell,Josef Frank,Lude Franke,Robert Freedman,Nelson B. Freimer,Marion Friedl,Joseph I. Friedman,Menachem Fromer,Menachem Fromer,Menachem Fromer,Giulio Genovese,Lyudmila Georgieva,Ina Giegling,Ina Giegling,Paola Giusti-Rodríguez,Stephanie Godard,Jacqueline I. Goldstein,Jacqueline I. Goldstein,Vera Golimbet,Srihari Gopal,Jacob Gratten,Lieuwe de Haan,Christian Hammer,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Vahram Haroutunian,Vahram Haroutunian,Annette M. Hartmann,Frans Henskens,Stefan Herms,Stefan Herms,Joel N. Hirschhorn,Joel N. Hirschhorn,Per Hoffmann,Per Hoffmann,A. Hofman,Mads V. Hollegaard,David M. Hougaard,Masashi Ikeda,Inge Joa,Antonio Julià,René S. Kahn,Luba Kalaydjieva,Sena Karachanak-Yankova,Juha Karjalainen,David J. Kavanagh,Matthew C. Keller,James L. Kennedy,Andrey Khrunin,Yunjung Kim,Janis Klovins,James A. Knowles,Bettina Konte,Vaidutis Kučinskas,Zita Ausrele Kucinskiene,Hana Kuzelova-Ptackova,Anna K. Kähler,Claudine Laurent,Jimmy Lee Chee Keong,S. Hong Lee,Sophie E. Legge,Bernard Lerer,Miaoxin Li,Tao Li,Kung-Yee Liang,Jeffrey A. Lieberman,Svetlana A. Limborska,Carmel M. Loughland,Jan Lubinski,Jouko Lönnqvist,Milan Macek,Patrik K. E. Magnusson,Brion S. Maher,Wolfgang Maier,J. Mallet,Sara Marsal,Manuel Mattheisen,Manuel Mattheisen,Manuel Mattheisen,Morten Mattingsdal,Robert W. McCarley,Colm McDonald,Andrew M. McIntosh,Sandra Meier,Carin J. Meijer,Béla Melegh,Ingrid Melle,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Younes Mokrab,Derek W. Morris,Derek W. Morris,Ole Mors,Ole Mors,Kieran C. Murphy,Robin M. Murray,Inez Myin-Germeys,Bertram Mueller-Myhsok,Mari Nelis,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Kristin K. Nicodemus,Liene Nikitina-Zake,Laura Nisenbaum,Annelie Nordin,Eadbhard O'Callaghan,Colm O'Dushlaine,F. Anthony O'Neill,Sang-Yun Oh,Ann Olincy,Line Olsen,Jim van Os,Jim van Os,Christos Pantelis,George N. Papadimitriou,Sergi Papiol,Elena Parkhomenko,Michele T. Pato,Tiina Paunio,Tiina Paunio,Milica Pejovic-Milovancevic,Diana O. Perkins,Olli Pietiläinen,Olli Pietiläinen,Jonathan Pimm,Andrew Pocklington,John Powell,Alkes L. Price,Alkes L. Price,Ann E. Pulver,Shaun Purcell,Digby Quested,Henrik B. Rasmussen,Abraham Reichenberg,Mark Reimers,Alexander Richards,Joshua L. Roffman,Panos Roussos,Douglas M. Ruderfer,Douglas M. Ruderfer,Veikko Salomaa,Alan R. Sanders,Ulrich Schall,Christian R. Schubert,Thomas G. Schulze,Thomas G. Schulze,Sibylle G. Schwab,Edward M. Scolnick,Rodney J. Scott,Larry J. Seidman,Jianxin Shi,Engilbert Sigurdsson,Teimuraz Silagadze,Jeremy M. Silverman,Jeremy M. Silverman,Kang Sim,Petr Slominsky,Jordan W. Smoller,Jordan W. Smoller,Hon-Cheong So,Chris C. A. Spencer,Eli A. Stahl,Eli A. Stahl,Hreinn Stefansson,Stacy Steinberg,Elisabeth Stögmann,Richard E. Straub,Eric Strengman,Jana Strohmaier,T. Scott Stroup,Mythily Subramaniam,Jaana Suvisaari,Dragan M. Svrakic,Jin P. Szatkiewicz,Erik Söderman,Srinivas Thirumalai,Draga Toncheva,Sarah Tosato,Juha Veijola,John L. Waddington,Dermot Walsh,Dai Wang,Qiang Wang,Bradley T. Webb,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Stephanie Williams,Stephanie H. Witt,Aaron R. Wolen,Emily H. M. Wong,Brandon Wormley,Hualin Simon Xi,Clement C. Zai,Xuebin Zheng,Fritz Zimprich,Naomi R. Wray,Kari Stefansson,Peter M. Visscher,Rolf Adolfsson,Ole A. Andreassen,Douglas Blackwood,Elvira Bramon,Joseph D. Buxbaum,Anders D. Børglum,Anders D. Børglum,Sven Cichon,Sven Cichon,Ariel Darvasi,Enrico Domenici,Hannelore Ehrenreich,Tõnu Esko,Tõnu Esko,Tõnu Esko,Pablo V. Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Noethen,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +354 more