Journal ArticleDOI
Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study.
John Abel Engh,Thor Ueland,Thor Ueland,Thor Ueland,Ingrid Agartz,Ingrid Agartz,Dimitrios Andreou,Dimitrios Andreou,Pål Aukrust,Pål Aukrust,Birgitte Boye,Birgitte Boye,Erlend Bøen,Ole Kristian Drange,Torbjørn Elvsåshagen,Sigrun Hope,Margrethe Collier Høegh,Inge Joa,Inge Joa,Erik Johnsen,Erik Johnsen,Rune A. Kroken,Rune A. Kroken,Trine Vik Lagerberg,Tove Lekva,Ulrik Fredrik Malt,Ingrid Melle,Ingrid Melle,Gunnar Morken,Terje Nærland,Terje Nærland,Vidar M. Steen,Vidar M. Steen,Kirsten Wedervang-Resell,Melissa Auten Weibell,Melissa Auten Weibell,Lars T. Westlye,Lars T. Westlye,Srdjan Djurovic,Srdjan Djurovic,Nils Eiel Steen,Nils Eiel Steen,Ole A. Andreassen,Ole A. Andreassen +43 more
TLDR
In this article, the authors investigated if plasma levels of BAFF and APRIL differed between patients with SCZ, BIP, and major depressive disorder (MDD), and tested for associations with psychotic symptom load, controlling for sociodemographic status, antipsychotic and other psychotropic medication, smoking, body mass index, and high sensitivity CRP.Abstract:
BACKGROUND Immune dysfunction has been implicated in the pathogenesis of schizophrenia and other nonaffective psychosis (SCZ), bipolar spectrum disorder (BIP) and major depressive disorder (MDD). The cytokines B cell-activating factor (BAFF) and A proliferation-inducing ligand (APRIL) belong to the tumor necrosis factor (TNF) super family and are essential in orchestrating immune responses. Abnormal levels of BAFF and APRIL have been found in autoimmune diseases with CNS affection. METHODS We investigated if plasma levels of BAFF and APRIL differed between patients with SCZ, BIP, and MDD with psychotic symptoms (n = 2009) and healthy control subjects (HC, n = 1212), and tested for associations with psychotic symptom load, controlling for sociodemographic status, antipsychotic and other psychotropic medication, smoking, body-mass-index, and high sensitivity CRP. RESULTS Plasma APRIL level was significantly lower across all patient groups compared to HC (P < .001; Cohen's d = 0.33), and in SCZ compared to HC (P < .001; d = 0.28) and in BIP compared to HC (P < .001; d = 0.37). Lower plasma APRIL was associated with higher psychotic symptom load with nominal significance (P = .017), but not with any other clinical characteristics. Plasma BAFF was not significantly different across patient groups vs HC, but significantly higher in BIP compared to HC (P = .040; d = 0.12) and SCZ (P = .027; d = 0.10). CONCLUSIONS These results show aberrant levels of BAFF and APRIL and association with psychotic symptoms in patients with SCZ and BIP. This suggest that dysregulation of the TNF system, mediated by BAFF and APRIL, is involved in the pathophysiology of psychotic disorders.read more
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Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis
Maren Caroline Frogner Werner,Katrine V. Wirgenes,Alexey A. Shadrin,Synve Hoffart Lunding,Linn Rødevand,Gabriela Hjell,M. Ormerod,Marit Haram,Ingrid Agartz,Srdjan Djurovic,Ingrid Melle,Pål Aukrust,Thor Ueland,Ole A. Andreassen,Nils Eiel Steen +14 more
TL;DR: In this article , the authors used the data from genome-wide association studies (GWAS) of autoimmune diseases and mental phenotypes associated with severe mental disorders (SMD) to disentangle genetic susceptibilities of immune abnormalities in SMD.
Journal ArticleDOI
The relationship between chronic immune response and neurodegenerative damage in long COVID-19
J. Pedro Elizalde-Díaz,Clara Leticia Miranda-Narváez,Juan Carlos Martínez-Lazcano,Eduardo Martínez-Martínez +3 more
TL;DR: In this paper , the authors explored the relationship between inflammatory and humoral immune markers and the major neurological damage manifested in post-COVID-19 patients, and found that the generation of autoantibodies affects processes such as neurogenesis, neuronal repair, chemotaxis and the optimal microglia function.
Journal ArticleDOI
Composite immune marker scores associated with severe mental disorders and illness course
Monica Bettina Elkjaer Greenwood Ormerod,Thor Ueland,Maren Caroline Frogner Werner,Gabriela Hjell,Linn Rødevand,Linn Sofie Sæther,Synve Hoffart Lunding,I. Johansen,Torill Ueland,Trine Vik Lagerberg,Ingrid Melle,Srdjan Djurovic,Ole A. Andreassen,Nils Eiel Steen +13 more
TL;DR: In this paper , the authors investigated how patterns across immune markers are related to diagnosis and illness course of severe mental disorders (SMDs) and found a complex pattern of immune pathways involved in SMDs and SCZ illness course.
Journal ArticleDOI
Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders
Maren Caroline Frogner Werner,Katrine V. Wirgenes,Alexey A. Shadrin,Synve Hoffart Lunding,Linn Rødevand,Gabriela Hjell,M. Ormerod,Marit Haram,Ingrid Agartz,Srdjan Djurovic,Ingrid Melle,Pål Aukrust,Thor Ueland,Ole A. Andreassen,Nils Eiel Steen +14 more
TL;DR: In this paper , the authors investigated if genetic susceptibility, infections or autoimmunity could explain the immune activation of patients with schizophrenia and bipolar disorder, and found that most of the low-grade inflammation in SCZ and BD is explained by other factors other than the underlying PRS, auto-infection, and infection rates.
Journal ArticleDOI
Association of Peripheral Inflammatory Biomarkers and Growth Factors Levels with Sex, Therapy and Other Clinical Factors in Schizophrenia and Patient Stratification Based on These Data
Evgeny A. Ermakov,Mark M. Melamud,Anastasiia S Boiko,Daria A Kamaeva,Svetlana Ivanova,Georgy A. Nevinsky,Valentina N. Buneva +6 more
TL;DR: In this article , the authors analyzed changes in serum concentrations of cytokines (IL-1β, IL-2, IL 4, IL 6, IL 10, IL 21, APRIL, BAFF, PBEF/Visfatin, IFN-α, and TNF-α) and growth/neurotrophic factors (GM-CSF, NRG1-β1, NGF-β, and GDNF) in patients with schizophrenia in an exacerbation phase.
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