PLGA-based nanoparticles as cancer drug delivery systems.
Fatemeh Sadat Tabatabaei Mirakabad,Kazem Nejati-Koshki,Abolfazl Akbarzadeh,Mohammad Rahmati Yamchi,Mortaza Milani,Nosratollah Zarghami,Vahideh Zeighamian,Amirbahman Rahimzadeh,Somayeh Alimohammadi,Younes Hanifehpour,Sang Woo Joo +10 more
TLDR
In this article, the structure and properties of poly (lactic-co-glycolic acid) copolymers synthesized by ring-opening polymerization of DL-lactide and glicolide were characterized using 1H nuclear magnetic resonance spectroscopy, gel permeation chromatography, Fourier transform infrared spectrograph and differential scanning calorimetry.Abstract:
Poly (lactic-co-glycolic acid) (PLGA) is one of the most effective biodegradable polymeric nanoparticles (NPs). It has been approved by the US FDA to use in drug delivery systems due to controlled and sustained- release properties, low toxicity, and biocompatibility with tissue and cells. In the present review, the structure and properties of PLGA copolymers synthesized by ring-opening polymerization of DL-lactide and glicolide were characterized using 1H nuclear magnetic resonance spectroscopy, gel permeation chromatography, Fourier transform infrared spectroscopy and differential scanning calorimetry. Methods of preparation and characterization, various surface modifications, encapsulation of diverse anticancer drugs, active or passive tumor targeting and different release mechanisms of PLGA nanoparticles are discussed. Increasing experience in the application of PLGA nanoparticles has provided a promising future for use of these nanoparticles in cancer treatment, with high efficacy and few side effects.read more
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Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy
TL;DR: This work presents a new generation of high-performance liquid chromatography platforms for selective separation of Na6(CO3) from Na4(SO4) through Na2SO4 and shows real-world applications in drug discovery and treatment of central nervous system disorders.
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Dendrimers: synthesis, applications, and properties
Elham Abbasi,Sedigheh Fekri Aval,Abolfazl Akbarzadeh,Morteza Milani,Hamid Tayefi Nasrabadi,Sang Woo Joo,Younes Hanifehpour,Kazem Nejati-Koshki,Roghiyeh Pashaei-Asl +8 more
TL;DR: A variety of dendrimers exist, and each has biological properties such as polyvalency, self-assembling, electrostatic interactions, chemical stability, low cytotoxicity, and solubility that make them a good choice in the medical field.
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Carbon nanotubes: properties, synthesis, purification, and medical applications
Ali Eatemadi,Hadis Daraee,Hamzeh Karimkhanloo,Mohammad Kouhi,Nosratollah Zarghami,Abolfazl Akbarzadeh,Mozhgan Abasi,Younes Hanifehpour,Sang Woo Joo +8 more
TL;DR: The strength and flexibility of carbon nanotubes make them of potential use in controlling other nanoscale structures, which suggests they will have a significant role in nanotechnology engineering.
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Insight into nanoparticle cellular uptake and intracellular targeting
Basit Yameen,Won Il Choi,Cristian Vilos,Archana Swami,Jinjun Shi,Omid C. Farokhzad,Omid C. Farokhzad +6 more
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Application of gold nanoparticles in biomedical and drug delivery
Hadis Daraee,Ali Eatemadi,Elham Abbasi,Sedigheh Fekri Aval,Mohammad Kouhi,Abolfazl Akbarzadeh +5 more
TL;DR: In this review, some important applications of gold nanoparticles are explained, including those as sensing, image enhancement, and delivery agents in medicine.
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