Journal ArticleDOI
Poly(N‐isopropylacrylamide) hydrogel: Effect of hydrophilicity on controlled release of ibuprofen at different pH
Reads0
Chats0
TLDR
In this article, a crosslinked NIPAM-co-MAc hydrogel loaded with ibuprofen into different pH buffer solutions was successfully carried out at temperature swing between 25 and 40°C.Abstract:
Stimuli-sensitive drug delivery systems (DDSs) have attracted considerable attention in medical and pharmaceutical fields; thermo-sensitive DDS dealing with poly(N-isopropylacrylamide) (PNIPAM) have been widely studied. Hydrogels composed of temperature-sensitive NIPAM and biocompatible and pH-sensitive maleic acid (MAc) were synthesized by sedimentation polymerization. Experiments on drug release from the crosslinked NIPAM-co-MAc hydrogel loaded with ibuprofen into different pH buffer solutions were successfully carried out at temperature swing between 25 and 40°C. The in vitro release studies have showed that the release rate depended on acidity or basicity (polarity) of the medium and the gel and swelling ratio of the gel network as a function of the environmental pH and temperature. The SEM image of the dry bead gave more insight into the surface architecture and the thermal studies shine light on the decomposition pattern and glass transition temperature of the gel. The mechanism of the drug release was discussed in relation to the diffusion rate and the abrupt change in the pH of the medium. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011read more
Citations
More filters
Journal ArticleDOI
Stimulus-responsive hydrogels: Theory, modern advances, and applications
TL;DR: This extensive review identifies and discusses the multitude of response modalities that have been developed, including temperature, pH, chemical, light, electro, and shear-sensitive hydrogels.
Journal Article
Novel emulsions stabilized by pH and temperature sensitive microgels
TL;DR: In this paper, the authors used temperature and pH sensitive poly(N-isopropylacrylamide)(PNIPAM) microgel particles to control emulsion stability.
Journal ArticleDOI
Thermoresponsive microhydrogels: preparation, properties and applications
TL;DR: The main material cited is a representative temperature-sensitive polymer, poly(N-isopropyl acrylamide), but some other environment-friendly polymers such as cellulose derivatives are also reported.
Journal ArticleDOI
One-step synthesis of porous graphene-based hydrogels containing oil droplets for drug delivery†
TL;DR: In this article, a series of porous graphene-based hydrogels containing oil droplets is fabricated on the basis of Pickering emulsions co-stabilized by graphene oxide and Fe3O4 nanoparticles.
Journal ArticleDOI
Layer-by-Layer Assembly of Biopolyelectrolytes onto Thermo/pH-Responsive Micro/Nano-Gels.
TL;DR: Results demonstrate that the structure and properties of biocompatible multilayer films can be finely tuned by confinement onto stimuli-responsive gels, which thus provides new perspectives for biomedical applications, particularly in the controlled release of biomolecules, bio-sensors, gene delivery, tissue engineering and storage.
References
More filters
Journal ArticleDOI
Environment-sensitive hydrogels for drug delivery
Yong Qiu,Kinam Park +1 more
TL;DR: Development of environmentally sensitive hydrogels with a wide array of desirable properties can be made is a formidable challenge, however, if the achievements of the past can be extrapolated into the future, it is highly likely that responsive hydrogelWith such properties can been made.
Journal ArticleDOI
Hydrogels in pharmaceutical formulations.
TL;DR: The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.
Journal ArticleDOI
Hydrogels in drug delivery: progress and challenges
Todd Hoare,Daniel S. Kohane +1 more
TL;DR: Recent progress in overcoming challenges with regards to effectively delivering hydrogels inside the body without implantation, prolonging the release kinetics of drugs fromhydrogels, and expanding the nature of drugs which can be delivered using hydrogel-based approaches is discussed.
Journal ArticleDOI
Knocking down barriers: advances in siRNA delivery
TL;DR: An update on the progress of RNAi therapeutics is provided and novel synthetic materials for the encapsulation and intracellular delivery of nucleic acids are highlighted.
Related Papers (5)
Dual stimuli responsive poly( N -isopropylacrylamide- co -acrylic acid) hydrogels based on a β-cyclodextrin crosslinker: synthesis, properties, and controlled protein release
Jie Hu,Shiheng Zheng,Xinglong Xu +2 more