Polydopamine-based Implantable Multifunctional Nanocarpet for Highly Efficient Photothermal-chemo Therapy
Arjun Prasad Tiwari,Deval Prasad Bhattarai,Bikendra Maharjan,Sung Won Ko,Hak Yong Kim,Chan Hee Park,Cheol Sang Kim +6 more
TLDR
A design and fabricate multifunctional localized platform for cancer therapy utilizing pH and NIR dual responsive property from PDA alone in a fibrous mat is presented, a major step forward towards a therapeutic model to cancer treatment.Abstract:
We report a design and fabricate multifunctional localized platform for cancer therapy. Multiple stimuli-responsive polydopamine (PDA) was used for surface modification of electrospun doxorubicin hydrochloride (DOX) loaded polycaprolactone (PCL) fibers to make a designated platform. Photothermal properties such as photothermal performance and stability of the resulting composite mats were studied under the irradiation of the near-infrared (NIR) laser of 808 nm. With the incorporation of PDA into the fiber, a remarkable increase of local temperature was recorded under NIR illumination in a concentration-dependent manner with excellent stability. Drug released assay results revealed PDA coated PCL-DOX mats showed pH and NIR dual responsive behavior thereby exhibiting improved drug release in an acidic medium compared to physiological pH condition (pH 7.4) which is further increased by NIR exposure. The cancer activity in vitro of the mats was evaluated using cell counting (CCK) and live and dead cell assays. The combined effect of NIR mediated hyperthermia and chemo release resulting improved cells death has been reported. In summary, this study presents a major step forward towards a therapeutic model to cancer treatment utilizing pH and NIR dual responsive property from PDA alone in a fibrous mat.read more
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Polyaniline-coated titanium oxide nanoparticles and simvastatin-loaded poly(ε-caprolactone) composite nanofibers scaffold for bone tissue regeneration application
Abdelrahman I. Rezk,Deval Prasad Bhattarai,Deval Prasad Bhattarai,Jeesoo Park,Chan Hee Park,Cheol Sang Kim +5 more
TL;DR: These novel composite nanofibers release simvastatin in a controlled manner with profound cell proliferation and attachment compared to that in pure PCL nanofiber, which indicates their potential for bone regeneration applications.
Journal ArticleDOI
Recent advances on nanoparticle-based photothermal therapy for breast cancer.
Sania Ghobadi Alamdari,Mohammad Amin Amini,Nazila Jalilzadeh,Behzad Baradaran,Reza Mohammadzadeh,Ahad Mokhtarzadeh,Fatemeh Oroojalian +6 more
TL;DR: In this article , the authors introduced the performance of light therapy, application of metal nanoparticles, polymer nanoparticles and carbon nanoparticles for use in photothermal therapy (PTT) of breast cancer.
Journal ArticleDOI
Three dimensional polycaprolactone/cellulose scaffold containing calcium-based particles: a new platform for bone regeneration.
So Eun Kim,Arjun Prasad Tiwari +1 more
TL;DR: A three-dimensional hierarchical multilayer scaffold with additional functionality by the modified gas-foaming technique that promoted cellular infiltration, mineralization and osteogenesis and may advance the development of 2D electrospun based scaffolds for biomedical applications.
Journal ArticleDOI
Assessment of ampicillin removal efficiency from aqueous solution by polydopamine/zirconium(IV) iodate: optimization by response surface methodology
Nafisur Rahman,Poornima Varshney +1 more
TL;DR: In this paper, polydopamine/zirconium(IV) iodate was used as an effective adsorbent for ampicillin removal and the effect of experimental variables on the removal process was examined using response surface methodology.
Journal ArticleDOI
pH-Responsive Electrospun Nanofibers and Their Applications
Jean Schoeller,Jean Schoeller,Fabian Itel,Karin Wuertz-Kozak,Karin Wuertz-Kozak,Giuseppino Fortunato,René M. Rossi,René M. Rossi +7 more
TL;DR: In this paper, a plethoroidal nanofibrous membrane with high membrane porosity and high surface-to-volume ratio (SVRR) was proposed for polymeric membranes.
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Wei Tao,Xianbing Zhu,Xinghua Yu,Xiaowei Zeng,Quanlan Xiao,Xudong Zhang,Xiaoyuan Ji,Xusheng Wang,Jinjun Shi,Han Zhang,Lin Mei +10 more
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