Polymeric nanoparticles: production, characterization, toxicology and ecotoxicology
Aleksandra Zielińska,Filipa Carreiró,Ana Oliveira,Andreia Neves,Bárbara Pires,D. Nagasamy Venkatesh,Alessandra Durazzo,Massimo Lucarini,Piotr Eder,Amélia M. Silva,Antonello Santini,Eliana B. Souto +11 more
TLDR
The most commonly used methods for the production and characterization of polymeric NPs are discussed, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms are discussed.Abstract:
Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms. As the safety of nanoparticles is a high priority, we also discuss the toxicology and ecotoxicology of nanoparticles to humans and to the environment.read more
Citations
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Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment
Ruiqiang Li,Cong Luo,Zhiqing Pang,Jinming Zhang,Shaobo Ruan,Meiying Wu,Lei Wang,Tao Sun,Nan Li,Liang Han,Jinjin Shi,Yuanyu Huang,Weisheng Guo,Shaojun Peng,Wen-Hui Zhou,Huile Gao +15 more
TL;DR: In this article , the authors summarized the advances of nanoparticles in recent years, and classifiably illustrated their components, strategies and functions, with their property and functions concluded, and some delivery strategies that make nanoparticles smarter and more efficient in drug delivery, and frontiers in these strategies are also summarized in this review.
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Drug release study of the chitosan-based nanoparticles
TL;DR: In this article , the authors discuss the relationship between the modification in CSNPs as multifunctional delivery systems and drug release properties and kinetics of the drug release model, and conclude that almost all CSNs showed bi-phasic release, initial burst release drug in a particular time followed controlled manner release in achieving the expected release, stimuli external can be applied.
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Clinical translation of nanomedicines: Challenges, opportunities, and keys
Tomislav Maršić,Eliane Vaz Souza1; Danyella Raymundo da Silva1; Juliana Silveira Gonçalves da Silva1; Eduardo …,Jeremy Horder +2 more
TL;DR: In this paper , the status, market situation, and clinical profiles of the reported nanomedicines, the shortcomings limiting their clinical translation, as well as some approaches designed to break through this barrier are summarized and evaluated.
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Polymeric Nanoparticles for Antimicrobial Therapies: An Up-To-Date Overview.
Vera Alexandra Spirescu,Cristina Chircov,Alexandru Mihai Grumezescu,Alexandru Mihai Grumezescu,Ecaterina Andronescu +4 more
TL;DR: In this paper, the authors provide an up-to-date overview of the most recent studies investigating polymeric nanoparticles designed for antimicrobial therapies, describing both their targeting strategies and their effects.
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Smart nanomaterial and nanocomposite with advanced agrochemical activities.
TL;DR: In this article, the authors highlight the role of nanomaterial or nanocomposite as a sustainable as well stable alternative in crop protection and production and highlight the information on the controlled released system, role in interaction with soil and microbiome, the promising role of nanopesticide, nanoherbicide, nanofertilizer, and their limitations in agrochemical activities.
References
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Biodegradable polymeric nanoparticles as drug delivery devices
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.
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Nanoparticles: Properties, applications and toxicities
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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
TL;DR: This work has shown that addition of PEG and PEG-containing copolymers to the surface of nanoparticles results in an increase in the blood circulation half-life of the particles by several orders of magnitude, and creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces.
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Drug delivery and nanoparticles:applications and hazards
Wim H. de Jong,Paul J A Borm +1 more
TL;DR: An overview on some of the currently used systems for drug delivery, varying from biological substances like albumin, gelatine and phospholipids for liposomes, and more substances of a chemical nature like various polymers and solid metal containing nanoparticles is provided.
Journal ArticleDOI
Nano based drug delivery systems: recent developments and future prospects
Jayanta Kumar Patra,Gitishree Das,Leonardo Fernandes Fraceto,Leonardo Fernandes Fraceto,Estefania Vangelie Ramos Campos,Estefania Vangelie Ramos Campos,Maria del Pilar Rodriguez-Torres,Laura Susana Acosta-Torres,Luis A. Diaz-Torres,Renato Grillo,Mallappa Kumara Swamy,Shivesh Sharma,Solomon Habtemariam,Han-Seung Shin +13 more
TL;DR: An updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs and selective diagnosis through disease marker molecules is presented.
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