Liposome: classification, preparation, and applications
Abolfazl Akbarzadeh,Rogaie Rezaei-Sadabady,Rogaie Rezaei-Sadabady,Soodabeh Davaran,Sang Woo Joo,Nosratollah Zarghami,Younes Hanifehpour,Mohammad Samiei,Mohammad Kouhi,Kazem Nejati-Koshki +9 more
TLDR
This paper summarizes exclusively scalable techniques and focuses on strengths and limitations in respect to industrial applicability and regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.Abstract:
Liposomes, sphere-shaped vesicles consisting of one or more phospholipid bilayers, were first described in the mid-60s. Today, they are a very useful reproduction, reagent, and tool in various scientific disciplines, including mathematics and theoretical physics, biophysics, chemistry, colloid science, biochemistry, and biology. Since then, liposomes have made their way to the market. Among several talented new drug delivery systems, liposomes characterize an advanced technology to deliver active molecules to the site of action, and at present, several formulations are in clinical use. Research on liposome technology has progressed from conventional vesicles to ‘second-generation liposomes’, in which long-circulating liposomes are obtained by modulating the lipid composition, size, and charge of the vesicle. Liposomes with modified surfaces have also been developed using several molecules, such as glycolipids or sialic acid. This paper summarizes exclusively scalable techniques and focuses on strengths, respectively, limitations in respect to industrial applicability and regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.read more
Citations
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Nano based drug delivery systems: recent developments and future prospects
Jayanta Kumar Patra,Gitishree Das,Leonardo Fernandes Fraceto,Leonardo Fernandes Fraceto,Estefania Vangelie Ramos Campos,Estefania Vangelie Ramos Campos,Maria del Pilar Rodriguez-Torres,Laura Susana Acosta-Torres,Luis A. Diaz-Torres,Renato Grillo,Mallappa Kumara Swamy,Shivesh Sharma,Solomon Habtemariam,Han-Seung Shin +13 more
TL;DR: An updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs and selective diagnosis through disease marker molecules is presented.
Journal ArticleDOI
Dendrimers: synthesis, applications, and properties
Elham Abbasi,Sedigheh Fekri Aval,Abolfazl Akbarzadeh,Morteza Milani,Hamid Tayefi Nasrabadi,Sang Woo Joo,Younes Hanifehpour,Kazem Nejati-Koshki,Roghiyeh Pashaei-Asl +8 more
TL;DR: A variety of dendrimers exist, and each has biological properties such as polyvalency, self-assembling, electrostatic interactions, chemical stability, low cytotoxicity, and solubility that make them a good choice in the medical field.
Journal ArticleDOI
Carbon nanotubes: properties, synthesis, purification, and medical applications
Ali Eatemadi,Hadis Daraee,Hamzeh Karimkhanloo,Mohammad Kouhi,Nosratollah Zarghami,Abolfazl Akbarzadeh,Mozhgan Abasi,Younes Hanifehpour,Sang Woo Joo +8 more
TL;DR: The strength and flexibility of carbon nanotubes make them of potential use in controlling other nanoscale structures, which suggests they will have a significant role in nanotechnology engineering.
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The Smart Drug Delivery System and Its Clinical Potential
TL;DR: The recent advances of smart nanoplatforms for targeting drug delivery, including stimuli-responsive polymeric nanoparticles, liposomes, metals/metal oxides, and exosomes are highlighted.
Journal ArticleDOI
Liposomes and polymersomes: a comparative review towards cell mimicking.
TL;DR: This work compares and contrast liposomes and polymersomes for a better a priori choice and design of vesicles and tries to understand the advantages and shortcomings associated with using one or the other in many different aspects.
References
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