Journal ArticleDOI
Post-lanosterol biosynthesis of cholesterol and cancer.
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TLDR
The relevance of these processes in cancer underscores the interest for studying the role of cholesterol in tumorigenesis and exploring the possibility of interfering with the growth of malignant cells by manipulation of cholesterol metabolism.About:
This article is published in Current Opinion in Pharmacology.The article was published on 2012-12-01. It has received 24 citations till now. The article focuses on the topics: Lanosterol & Cellular differentiation.read more
Citations
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Journal ArticleDOI
Cholesterol and Cancer, in the Balance
TL;DR: The important question of how to regulate or inhibit the cholesterol metabolic pathway, and at which steps, in a therapeutic approach to cancer is raised.
Journal ArticleDOI
Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4
TL;DR: It is shown that the expression levels of acyl-CoA synthetase long-chain family member 4 (ACSL4) were negatively associated with those of miR-205 in clinical HCC tissues, and it is validated that miR -205 was able to inhibit the expression of ACSL4 at the levels of mRNA and protein through targeting its 3'UTR.
Journal ArticleDOI
Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases.
Anna Kloska,Magdalena Węsierska,Marcelina Malinowska,Magdalena Gabig-Cimińska,Magdalena Gabig-Cimińska,Joanna Jakóbkiewicz-Banecka +5 more
TL;DR: This review discusses how lipophagy and cytosolic lipolysis degrade cellular lipids, as well as how these pathway communicate, how they affect lipid metabolism and energy homeostasis in cells and how their dysfunction affects the pathogenesis of lipid storage and lipid metabolism diseases.
Journal ArticleDOI
Comprehensive gas chromatography-electron ionisation mass spectrometric analysis of fatty acids and sterols using sequential one-pot silylation: quantification and isotopologue analysis
Dick-Paul Kloos,Dick-Paul Kloos,Henk Lingeman,Franz Bracher,Christoph Müller,Oleg A. Mayboroda,André M. Deelder,Wilfried M. A. Niessen,Martin Giera +8 more
TL;DR: The presented method successfully combines two consecutive silylation reactions in one pot, enabling the analysis of both fatty acids and sterols in a comprehensive analytical method with great potential for the quantification of lipids as well as the comprehensive study of both biochemical pathways, using [(13)C]-flux analysis.
References
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microRNAs as oncogenes and tumor suppressors.
TL;DR: More than 50% of miRNA genes are located in cancer-associated genomic regions or in fragile sites, suggesting that miRNAs may play a more important role in the pathogenesis of a limited range of human cancers than previously thought.
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miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.
Christine Esau,Scott Davis,Susan F. Murray,Xing Xian Yu,Sanjay K. Pandey,Michael Pear,Lynnetta Watts,Sheri L. Booten,Mark J. Graham,Robert Mckay,Amuthakannan Subramaniam,Stephanie Propp,Bridget Lollo,Susan M. Freier,C. Frank Bennett,Sanjay Bhanot,Brett P. Monia +16 more
TL;DR: IMR-122 inhibition in a diet-induced obesity mouse model resulted in decreased plasma cholesterol levels and a significant improvement in liver steatosis, accompanied by reductions in several lipogenic genes, suggesting that miR- 122 may be an attractive therapeutic target for metabolic disease.
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MiR-33 Contributes to the Regulation of Cholesterol Homeostasis
Katey J. Rayner,Yajaira Suárez,Alberto Dávalos,Saj Parathath,Michael L. Fitzgerald,Norimasa Tamehiro,Edward A. Fisher,Kathryn J. Moore,Kathryn J. Moore,Carlos Fernández-Hernando +9 more
TL;DR: It is shown that miR-33, an intronic microRNA located within the gene encoding sterol-regulatory element–binding factor–2 (SREBF-2), a transcriptional regulator of cholesterol synthesis, modulates the expression of genes involved in cellular cholesterol transport.
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MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis
S. Hani Najafi-Shoushtari,Fjoralba Kristo,Yingxia Li,Toshi Shioda,David E. Cohen,Robert E. Gerszten,Anders M. Näär +6 more
TL;DR: It is shown that microRNAs embedded within introns of the SREBP genes target the adenosine triphosphate–binding cassette transporter A1, an important regulator of high-density lipoprotein (HDL) synthesis and reverse cholesterol transport, for posttranscriptional repression.
Journal ArticleDOI
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
William A. Freed-Pastor,Hideaki Mizuno,Xi Zhao,Anita Langerød,Sung Hwan Moon,Ruth Rodriguez-Barrueco,Anthony M. Barsotti,Agustin Chicas,Wencheng Li,Alla Polotskaia,Mina J. Bissell,Timothy F. Osborne,Bin Tian,Scott W. Lowe,Jose M. Silva,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Arnold J. Levine,Jill Bargonetti,Carol Prives +19 more
TL;DR: It is found that mutant p53 depletion is sufficient to phenotypically revert breast cancer cells to a more acinar-like morphology, which implicate the mevalonate pathway as a therapeutic target for tumors bearing mutations in p53.