Journal ArticleDOI
Potential Utility of Melatonin in Preeclampsia, Intrauterine Fetal Growth Retardation, and Perinatal Asphyxia
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TLDR
Melatonin treatment during the late fetal and early neonatal period might result in a wide range of health benefits, improved quality of life, and may help limit complications during the critical periods prior to, and shortly after, delivery.Abstract:
Aim:Reactive oxygen species play an important role in the pathogenesis of several diseases during gestation and the perinatal period. During pregnancy, increased oxygen demand augments the rate of ...read more
Citations
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Journal ArticleDOI
Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care.
Anna Tarocco,Natascia Caroccia,Giampaolo Morciano,Mariusz R. Wieckowski,Gina Ancora,Giampaolo Garani,Paolo Pinton +6 more
TL;DR: Molecular pathways in which melatonin is considered a master regulator, with attention to cell death and inflammation mechanisms from basic, translational and clinical points of view in the context of newborn care are summarized.
Journal ArticleDOI
Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early-onset preeclampsia.
Sebastian R. Hobson,Seshini Gurusinghe,Rebecca Lim,Rebecca Lim,Nicole O. Alers,Suzanne L. Miller,Suzanne L. Miller,John Kingdom,Euan M. Wallace,Euan M. Wallace +9 more
TL;DR: It is shown that melatonin has the potential to mitigate maternal endothelial pro‐oxidant injury and could therefore provide effective adjuvant therapy to extend pregnancy duration to deliver improved clinical outcomes for women with severe preeclampsia.
Journal ArticleDOI
Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action.
Pawel Posadzki,Ram Bajpai,Bhone Myint Kyaw,Nicola J. Roberts,Amnon Brzezinski,George I. Christopoulos,Ushashree Divakar,Shweta Bajpai,Michael Soljak,Gerard Dunleavy,Krister Järbrink,Ei Ei Khaing Nang,Chee Kiong Soh,Josip Car,Josip Car +14 more
TL;DR: Melatonin has been shown to be associated with a wide variety of health outcomes in clinically and methodologically heterogeneous populations and many reviews stressed the need for more high-quality randomised clinical trials to reduce the existing uncertainties.
Journal ArticleDOI
Melatonin modulates autophagy and inflammation protecting human placental trophoblast from hypoxia/reoxygenation
Lucas Sagrillo-Fagundes,Lucas Sagrillo-Fagundes,Eugania Maria Assuncao Salustiano,Rodrigo Ruano,Regina P. Markus,Cathy Vaillancourt,Cathy Vaillancourt +6 more
TL;DR: It is suggested that H/R, which is present in pregnancy complications, inhibits endogenous melatonin production, thereby contributing to reduced syncytiotrophoblast viability and contributing to improved fetal outcomes.
Journal ArticleDOI
Endometriosis Pathoetiology and Pathophysiology: Roles of Vitamin A, Estrogen, Immunity, Adipocytes, Gut Microbiome and Melatonergic Pathway on Mitochondria Regulation.
TL;DR: Data on the pathoetiology and pathophysiology of endometriosis is reviewed, suggesting key roles for alterations in mitochondria functioning across a number of cell types and body systems, including the immune system and gut microbiome.
References
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Journal ArticleDOI
Regulation of antioxidant enzymes: a significant role for melatonin.
Carmen Rodríguez,Juan C. Mayo,Rosa M. Sainz,Isaac Antolín,Federico Herrera,Vanesa Martín,Russel J. Reiter +6 more
TL;DR: This report reviews the studies which document the influence of melatonin on the activity and expression of the antioxidative enzymes glutathione peroxidase, superoxide dismutases and catalase both under physiological and under conditions of elevated oxidative stress and analyses the possible mechanisms by which melatonin regulates these enzymes.
Journal ArticleDOI
On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK.
TL;DR: Melatonin and its metabolite AMK constitute an efficient team of scavengers able of deactivating a wide variety of reactive oxygen species, under different conditions, and the presented results support the continuous protection exerted by melatonin, through the free radical scavenging cascade.
Book ChapterDOI
Melatonin: a multitasking molecule.
TL;DR: Melatonin has revealed itself as an ubiquitously distributed and functionally diverse molecule that influences the molecular physiology of cells via receptor-independent means and may well find applications in both human and veterinary medicine.
Journal ArticleDOI
Daily Nighttime Melatonin Reduces Blood Pressure in Male Patients With Essential Hypertension
TL;DR: In patients with essential hypertension, repeated bedtime melatonin intake significantly reduced nocturnal blood pressure and support of circadian pacemaker function may provide a new strategy in the treatment of essential hypertension.