Journal ArticleDOI
Potential virulence factors of Proteus bacilli.
TLDR
The genus Proteus, which contains bacteria considered now to belong to the opportunistic pathogens, has its most characteristic attribute, swarming growth, enabling them to colonize and survive in higher organisms.Abstract:
The object of this review is the genus Proteus, which contains bacteria considered now to belong to the opportunistic pathogens. Widely distributed in nature (in soil, water, and sewage), Proteus species play a significant ecological role. When present in the niches of higher macroorganisms, these species are able to evoke pathological events in different regions of the human body. The invaders (Proteus mirabilis, P. vulgaris, and P. penneri) have numerous factors including fimbriae, flagella, outer membrane proteins, lipopolysaccharide, capsule antigen, urease, immunoglobulin A proteases, hemolysins, amino acid deaminases, and, finally, the most characteristic attribute of Proteus, swarming growth, enabling them to colonize and survive in higher organisms. All these features and factors are described and commented on in detail. The questions important for future investigation of these facultatively pathogenic microorganisms are also discussed.read more
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Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria
TL;DR: Current knowledge concerning the different strategies bacteria employ to resist the activities of polymyxins are summarized and increased understanding of these mechanisms is extremely vital and timely to facilitate studies of antimicrobial peptides and find new potential drugs targeting clinically relevant Gram-negative bacteria.
Journal ArticleDOI
Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: The 'red complex', a prototype polybacterial pathogenic consortium in periodontitis
Journal ArticleDOI
Complicated Catheter-Associated Urinary Tract Infections Due to Escherichia coli and Proteus mirabilis
TL;DR: Research focusing on the pathogenesis of CAUTIs will lead to a better understanding of the disease process and will subsequently lead to the development of new diagnosis, prevention, and treatment options.
Journal ArticleDOI
Structure of bacterial lipopolysaccharides.
Martine Caroff,D Karibian +1 more
TL;DR: Bacterial lipopolysaccharides are the major components of the outer surface of Gram-negative bacteria and are often of interest in medicine for their immunomodulatory properties.
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Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37
TL;DR: The results indicate that proteolytic degradation of LL‐37 is a common virulence mechanism and that molecules which block this degradation could have therapeutic potential.
References
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Bacterial Adherence to Cell Surface Sugars
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Proteus mirabilis amino acid deaminase: cloning, nucleotide sequence, and characterization of aad.
TL;DR: A gene encoding an amino acid deaminase of uropathogenic Proteus mirabilis was identified by screening a genomic library hosted in Escherichia coli DH5 alpha for amino acids activity and did not share significant amino acid sequence similarity with any other polypeptide in the PIR or SwissProt database.
Journal ArticleDOI
Attachment of Proteus mirabilis to human urinary sediment epithelial cells in vitro is different from that of Escherichia coli.
C S Edén,P Larsson,H. Lomberg +2 more
TL;DR: Differences in adhesion characteristics of E. coli and P. mirabilis may relate to the differences in clinical appearance of urinary tract infections produced by the two organisms.
Journal ArticleDOI
Proteus mirabilis MR/P fimbrial operon: Genetic organization, nucleotide sequence, and conditions for expression
F. K. Bahrani,Harry L. T. Mobley +1 more
TL;DR: The mrp gene cluster encoded by 7,293 bp predicts eight polypeptides that share > or = 25% amino acid identity with at least one other enteric fimbrial gene product encoded by the pap, fim, smf, fan, or mrk gene clusters.
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