Journal ArticleDOI
Potential virulence factors of Proteus bacilli.
TLDR
The genus Proteus, which contains bacteria considered now to belong to the opportunistic pathogens, has its most characteristic attribute, swarming growth, enabling them to colonize and survive in higher organisms.Abstract:
The object of this review is the genus Proteus, which contains bacteria considered now to belong to the opportunistic pathogens. Widely distributed in nature (in soil, water, and sewage), Proteus species play a significant ecological role. When present in the niches of higher macroorganisms, these species are able to evoke pathological events in different regions of the human body. The invaders (Proteus mirabilis, P. vulgaris, and P. penneri) have numerous factors including fimbriae, flagella, outer membrane proteins, lipopolysaccharide, capsule antigen, urease, immunoglobulin A proteases, hemolysins, amino acid deaminases, and, finally, the most characteristic attribute of Proteus, swarming growth, enabling them to colonize and survive in higher organisms. All these features and factors are described and commented on in detail. The questions important for future investigation of these facultatively pathogenic microorganisms are also discussed.read more
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Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria
TL;DR: Current knowledge concerning the different strategies bacteria employ to resist the activities of polymyxins are summarized and increased understanding of these mechanisms is extremely vital and timely to facilitate studies of antimicrobial peptides and find new potential drugs targeting clinically relevant Gram-negative bacteria.
Journal ArticleDOI
Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: The 'red complex', a prototype polybacterial pathogenic consortium in periodontitis
Journal ArticleDOI
Complicated Catheter-Associated Urinary Tract Infections Due to Escherichia coli and Proteus mirabilis
TL;DR: Research focusing on the pathogenesis of CAUTIs will lead to a better understanding of the disease process and will subsequently lead to the development of new diagnosis, prevention, and treatment options.
Journal ArticleDOI
Structure of bacterial lipopolysaccharides.
Martine Caroff,D Karibian +1 more
TL;DR: Bacterial lipopolysaccharides are the major components of the outer surface of Gram-negative bacteria and are often of interest in medicine for their immunomodulatory properties.
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Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37
TL;DR: The results indicate that proteolytic degradation of LL‐37 is a common virulence mechanism and that molecules which block this degradation could have therapeutic potential.
References
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Journal Article
Some biological features of Proteus bacilli. 2. Haemolytic activities of Proteus mirabilis and Proteus vulgaris strains.
TL;DR: Another kind of haemolytic activity was observed when P. mirabilis and P. vulgaris strains were grown in liquid media supplemented with erythrocytes and except for Serratia, the other representatives of Enterobacteriaceae did not demonstrate such activity in the same conditions.
Journal ArticleDOI
Cell-free and cell-bound hemolytic activities of Proteus penneri determined by different Hly determinants.
TL;DR: It is shown, using the colony hybridization technique, that the alpha-hemolysin-like determinant is widely distributed among Proteus penneri strains and the existence of another control mechanism external to the hly operon for hemolysin gene is suggested.
Journal ArticleDOI
Lipopolysaccharides of Proteus penneri species novum.
Krystyna Zych,Zygmunt Sidorczyk +1 more
TL;DR: The lipopolysaccharides (LPS), obtained from twenty strains of Proteus penneri, were shown to contain 3-deoxy-D-manno-2-octulosonic acid (KDO), L-glycero-D
Journal ArticleDOI
The bacteriology of urinary infections in paraplegia
TL;DR: It appears that infections in the urinary tract by more than one type of organism at a time occur more frequently in those patients with the more chronic predisposing causes.
Journal ArticleDOI
Modulation of effects of lipopolysaccharide on macrophages by a major outer membrane protein of Proteus mirabilis as measured in a chemiluminescence assay.
TL;DR: The immunomodulating effects of the 39-kDa protein were tested at the level of interaction of LPS with macrophages and methylated bovine serum albumin enhanced the response of macrophage dramatically when complexed with LPS.
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