Journal ArticleDOI
Potential virulence factors of Proteus bacilli.
TLDR
The genus Proteus, which contains bacteria considered now to belong to the opportunistic pathogens, has its most characteristic attribute, swarming growth, enabling them to colonize and survive in higher organisms.Abstract:
The object of this review is the genus Proteus, which contains bacteria considered now to belong to the opportunistic pathogens. Widely distributed in nature (in soil, water, and sewage), Proteus species play a significant ecological role. When present in the niches of higher macroorganisms, these species are able to evoke pathological events in different regions of the human body. The invaders (Proteus mirabilis, P. vulgaris, and P. penneri) have numerous factors including fimbriae, flagella, outer membrane proteins, lipopolysaccharide, capsule antigen, urease, immunoglobulin A proteases, hemolysins, amino acid deaminases, and, finally, the most characteristic attribute of Proteus, swarming growth, enabling them to colonize and survive in higher organisms. All these features and factors are described and commented on in detail. The questions important for future investigation of these facultatively pathogenic microorganisms are also discussed.read more
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Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria
TL;DR: Current knowledge concerning the different strategies bacteria employ to resist the activities of polymyxins are summarized and increased understanding of these mechanisms is extremely vital and timely to facilitate studies of antimicrobial peptides and find new potential drugs targeting clinically relevant Gram-negative bacteria.
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Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: The 'red complex', a prototype polybacterial pathogenic consortium in periodontitis
Journal ArticleDOI
Complicated Catheter-Associated Urinary Tract Infections Due to Escherichia coli and Proteus mirabilis
TL;DR: Research focusing on the pathogenesis of CAUTIs will lead to a better understanding of the disease process and will subsequently lead to the development of new diagnosis, prevention, and treatment options.
Journal ArticleDOI
Structure of bacterial lipopolysaccharides.
Martine Caroff,D Karibian +1 more
TL;DR: Bacterial lipopolysaccharides are the major components of the outer surface of Gram-negative bacteria and are often of interest in medicine for their immunomodulatory properties.
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Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37
TL;DR: The results indicate that proteolytic degradation of LL‐37 is a common virulence mechanism and that molecules which block this degradation could have therapeutic potential.
References
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Journal ArticleDOI
Glycopolymers from synthetic fragments (amides of α-D-galacturonic acid with amino acids) of proteus o-antigens
TL;DR: Galacturonamides of amino acids (alanine, lysine, serine, and threonine), constituents of Proteus O-specific polysaccharides, have been synthesised as discussed by the authors.
Journal Article
Research letterAlpha-haemolysin, a possible virulence factor in Proteus morganii
Journal ArticleDOI
Structural and immunochemical studies on the lipopolysaccharide of the ‘T-antigen’-containing mutant Proteus mirabilis R14/ 1959
Beata Bartodziejska,Joanna Radziejewska-Lebrecht,Maria Lipinska,Yuriy A. Knirel,Leonid O. Kononov,Anatoly Ya. Chernyak,Hubert Mayer,Antoni Rozalski +7 more
TL;DR: The importance of a D-GalA(L-Lys)-containing epitope and of GalA present in the T-antigen chain in manifesting the serological specificity of P. mirabilis R14/1959 were revealed using rabbit polyclonal homologous and heterologous R- and O-specific antisera and the appropriate antigens, including synthetic antigen which represent partial structures of various Proteus LPS.
Journal ArticleDOI
The production of HlyA toxin by Proteus penneri strains
TL;DR: In most strains the haemolysin was secreted into the medium during early exponential growth and lysed not only of a variety of erythrocyte types from several animals including man, but also human neutrophils and human embryo lung fibroblasts, believed to be an important virulence factor for this organism.
Journal ArticleDOI
Synthesis of lysine-containing fragments of the Proteus mirabilis O27 O-specific polysaccharide and neoglyco- conjugates therefrom
Anatoly Ya. Chernyak,Leonid O. Kononov,Palakodety Radha Krishna,Nikolay K. Kochetkov,Alla V. Rama Rao +4 more
TL;DR: Amide-linked lysine mono- and di-uronic acid fragments of the O-specific polysaccharide from P. mirabilis O27 have been synthesised and converted into high-molecular-weight copolymer-type neoglycoconjugates.
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