Journal ArticleDOI
Potential virulence factors of Proteus bacilli.
TLDR
The genus Proteus, which contains bacteria considered now to belong to the opportunistic pathogens, has its most characteristic attribute, swarming growth, enabling them to colonize and survive in higher organisms.Abstract:
The object of this review is the genus Proteus, which contains bacteria considered now to belong to the opportunistic pathogens. Widely distributed in nature (in soil, water, and sewage), Proteus species play a significant ecological role. When present in the niches of higher macroorganisms, these species are able to evoke pathological events in different regions of the human body. The invaders (Proteus mirabilis, P. vulgaris, and P. penneri) have numerous factors including fimbriae, flagella, outer membrane proteins, lipopolysaccharide, capsule antigen, urease, immunoglobulin A proteases, hemolysins, amino acid deaminases, and, finally, the most characteristic attribute of Proteus, swarming growth, enabling them to colonize and survive in higher organisms. All these features and factors are described and commented on in detail. The questions important for future investigation of these facultatively pathogenic microorganisms are also discussed.read more
Citations
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Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria
TL;DR: Current knowledge concerning the different strategies bacteria employ to resist the activities of polymyxins are summarized and increased understanding of these mechanisms is extremely vital and timely to facilitate studies of antimicrobial peptides and find new potential drugs targeting clinically relevant Gram-negative bacteria.
Journal ArticleDOI
Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: The 'red complex', a prototype polybacterial pathogenic consortium in periodontitis
Journal ArticleDOI
Complicated Catheter-Associated Urinary Tract Infections Due to Escherichia coli and Proteus mirabilis
TL;DR: Research focusing on the pathogenesis of CAUTIs will lead to a better understanding of the disease process and will subsequently lead to the development of new diagnosis, prevention, and treatment options.
Journal ArticleDOI
Structure of bacterial lipopolysaccharides.
Martine Caroff,D Karibian +1 more
TL;DR: Bacterial lipopolysaccharides are the major components of the outer surface of Gram-negative bacteria and are often of interest in medicine for their immunomodulatory properties.
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Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37
TL;DR: The results indicate that proteolytic degradation of LL‐37 is a common virulence mechanism and that molecules which block this degradation could have therapeutic potential.
References
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Journal ArticleDOI
Host-Parasite Interaction in the Urinary Tract
C. Svanborg Edén,S. Hausson,U. Jodal,Gunilla Lidin-Janson,K. Lincoln,H. Linder,H. Lomberg,P de Man,Staffan Mårild,Jeanette Martinell,Kaety A. E. Plos,Torsten Sandberg,K. Stenqvist +12 more
TL;DR: The complexity of UTI has contributed to its usefulness as a model system for studies of pathogenesis and the changes induced in the host by bacteria that enter this normally sterile site may be used to assess determinants of bacterial virulence and host resistance.
Journal ArticleDOI
4-Amino-4-deoxy-L-arabinose in LPS of enterobacterial R-mutants and its possible role for their polymyxin reactivity
Matthias Boll,Joanna Radziejewska-Lebrecht,Christoph Warth,Danuta Krajewska-Pietrasik,Hubert Mayer +4 more
TL;DR: The results obtained so far indicated that the inner core bound L-Arap4N, detected in all resistant strains investigated, may play a decisive role in the decreased binding of polymyxin B, responsible for the bacterial resistance towards poly myxin(s).
Journal ArticleDOI
Internalization of Proteus mirabilis by human renal epithelial cells.
TL;DR: It is suggested that HpmA hemolysin-mediated cytotoxicity and internalization of bacteria by HRPTEC may play a role in the development of Proteus pyelonephritis.
Journal ArticleDOI
Epitope specificities of murine monoclonal and rabbit polyclonal antibodies against enterobacterial lipopolysaccharides of the Re chemotype.
TL;DR: It is concluded that the immunodominant structures of Re LPS comprise both the KDO and lipid A domains.
Journal ArticleDOI
Capsule structure of Proteus mirabilis (ATCC 49565).
Linda M. Beynon,A. J. Dumanski,Robert J. C. McLean,Leann L. MacLean,James C. Richards,Malcolm B. Perry +5 more
TL;DR: Proteus mirabilis 2573 produces an acidic capsular polysaccharide which was shown from glycose analysis, carboxyl reduction, methylation, periodate oxidation, and the application of one dimensional and two-dimensional high-resolution nuclear magnetic resonance techniques to be a high-molecular-weight polymer of branched trisaccharide units.
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