Journal ArticleDOI
Potential virulence factors of Proteus bacilli.
TLDR
The genus Proteus, which contains bacteria considered now to belong to the opportunistic pathogens, has its most characteristic attribute, swarming growth, enabling them to colonize and survive in higher organisms.Abstract:
The object of this review is the genus Proteus, which contains bacteria considered now to belong to the opportunistic pathogens. Widely distributed in nature (in soil, water, and sewage), Proteus species play a significant ecological role. When present in the niches of higher macroorganisms, these species are able to evoke pathological events in different regions of the human body. The invaders (Proteus mirabilis, P. vulgaris, and P. penneri) have numerous factors including fimbriae, flagella, outer membrane proteins, lipopolysaccharide, capsule antigen, urease, immunoglobulin A proteases, hemolysins, amino acid deaminases, and, finally, the most characteristic attribute of Proteus, swarming growth, enabling them to colonize and survive in higher organisms. All these features and factors are described and commented on in detail. The questions important for future investigation of these facultatively pathogenic microorganisms are also discussed.read more
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Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria
TL;DR: Current knowledge concerning the different strategies bacteria employ to resist the activities of polymyxins are summarized and increased understanding of these mechanisms is extremely vital and timely to facilitate studies of antimicrobial peptides and find new potential drugs targeting clinically relevant Gram-negative bacteria.
Journal ArticleDOI
Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: The 'red complex', a prototype polybacterial pathogenic consortium in periodontitis
Journal ArticleDOI
Complicated Catheter-Associated Urinary Tract Infections Due to Escherichia coli and Proteus mirabilis
TL;DR: Research focusing on the pathogenesis of CAUTIs will lead to a better understanding of the disease process and will subsequently lead to the development of new diagnosis, prevention, and treatment options.
Journal ArticleDOI
Structure of bacterial lipopolysaccharides.
Martine Caroff,D Karibian +1 more
TL;DR: Bacterial lipopolysaccharides are the major components of the outer surface of Gram-negative bacteria and are often of interest in medicine for their immunomodulatory properties.
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Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37
TL;DR: The results indicate that proteolytic degradation of LL‐37 is a common virulence mechanism and that molecules which block this degradation could have therapeutic potential.
References
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Journal ArticleDOI
Extracellular Haemolysin of Proteus penneri Coded by Chromosomal hly Genes is Similar to the α-Haemolysin of Escherichia coli
TL;DR: The results presented here suggested that the haemolysin of P. penneri strains is chromosomally determined and similar to the alpha-haemoly sin of E. coli.
Journal Article
[Structural and immunologic studies of Proteus mirabilis 033 O-specific polysaccharide]
M. Cedzynski,Antoni Rozalski,K. Kotelko,W. Kaca,E. V. Vinogradov,Y.A. Knirel,N. K. Kochetkov +6 more
TL;DR: On the basis of the data obtained from 13C-NMR and methylation analysis, the following structure of repeating unit was established: Selective removal of the D-GlcA significantly decreased reactivity of 033 O-specific polysaccharide with homologous antiserum.
Journal Article
Bactericidal activity of normal human serum against Morganella, Proteus, and Providencia strains.
TL;DR: Following mechanisms of the bactericidal action of serum were found: complement activated by the classical or alternative pathway with participation of lysozyme, complement activated simultaneously via both pathways-while the participation of Lysozyme was necessary for killing some strains and superfluos for others and complement activated only via the classical pathway without lyso enzyme.
Journal ArticleDOI
Structural and immunochemical studies on the lipopolysaccharide of the ‘T-antigen’-containing mutant R14/1959
Beata Bartodziejska,Joanna Radziejewska-Lebrecht,M Lipinska,Yuriy A. Knirel,Leonid O. Kononov,Anatoly Ya. Chernyak,Hubert Mayer,Antoni Rozalski +7 more
Journal ArticleDOI
Characteristics of spontaneously agglutinating Proteus mirabilis strains from bacteriuric patients.
TL;DR: Data indicated that strains of P. mirabilis may be pathogenic even if they express very incomplete LPS, when tested in a hematogenous infection model in mice.
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