Prognostic factors in solitary plasmacytoma of the bone: a multicenter Rare Cancer Network study
David Knobel,Abderrahim Zouhair,Richard W. Tsang,Philip Poortmans,Yazid Belkacemi,Michel Bolla,Fazilet Dinçbas Oner,Christine Landmann,Bernard Castelain,Mahmut Ozsahin +9 more
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TLDR
Younger patients, especially those with vertebral localization have the best outcome when treated with moderate-dose RT, and progression to MM remains the main problem.Abstract:
Background: Solitary plasmacytoma (SP) of the bone is a rare plasma-cell neoplasm. There are no conclusive data in the literature on the optimal radiation therapy (RT) dose in SP. Therefore, in this large retrospective study, we wanted to assess the outcome, prognostic factors, and the optimal RT dose in patients with SP. Methods: Data from 206 patients with bone SP without evidence of multiple myeloma (MM) were collected. Histopathological diagnosis was obtained for all patients. The majority (n = 169) of the patients received RT alone; 32 chemotherapy and RT, and 5 surgery. Median follow-up was 54 months (7–245). Results: Five-year overall survival, disease-free survival (DFS), and local control was 70%, 46%, and 88%; respectively. Median time to MM development was 21 months (2–135) with a 5-year probability of 51%. In multivariate analyses, favorable factors were younger age and tumor size < 5 cm for survival; younger age for DFS; anatomic localization (vertebra vs. other) for local control. Older age was the only predictor for MM. There was no dose-response relationship for doses 30 Gy or higher, even for larger tumors. Conclusion: Younger patients, especially those with vertebral localization have the best outcome when treated with moderate-dose RT. Progression to MM remains the main problem. Further investigation should focus on adjuvant chemotherapy and/or novel therapeutic agents.read more
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Journal ArticleDOI
Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma : incidence and survival in the United States, 1992-2004
Graça M. Dores,Ola Landgren,Katherine A. McGlynn,Rochelle E. Curtis,Martha S. Linet,Susan S. Devesa +5 more
TL;DR: Five‐year relative survival for P‐bone, P‐extramedullary, and MM varied significantly by age (<60/60+ years), supporting age‐related differences in disease burden at presentation, disease biology, and/or treatment approaches.
Journal ArticleDOI
A Review for Solitary Plasmacytoma of Bone and Extramedullary Plasmacytoma
TL;DR: By only RT application, long-term disease-free survival (DFS) is possible for approximately 30% of patients with SBP and 65% of customers with EMP, and the choice of treatment is radiotherapy that is applied with curative intent at min. 4000 cGy.
Journal ArticleDOI
Multiple myeloma, version 3.2021
Shaji Kumar,Natalie S. Callander,Kehinde Adekola,Larry D. Anderson,Muhamed Baljevic,Erica L. Campagnaro,Jorge J. Castillo,Jason C. Chandler,Caitlin Costello,Yvonne A. Efebera,Matthew Faiman,Alfred L. Garfall,Kelly N. Godby,Jens Hillengass,Leona Holmberg,Myo Htut,Carol Ann Huff,Yubin Kang,Malin Hultcrantz,Sarah Larson,Michaela Liedtke,Thomas Martin,James L. Omel,Kenneth H. Shain,Douglas W. Sborov,Keith Stockerl-Goldstein,Donna M. Weber,Jennifer Keller,Rashmi Kumar +28 more
TL;DR: This manuscript discusses the management of patients with solitary plasmacytoma, smoldering multiple Myeloma, and newly diagnosed multiple myeloma.
Journal ArticleDOI
Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel
Jo Caers,Bruno Paiva,Elena Zamagni,Xavier Leleu,J. Bladé,Sigurdur Y. Kristinsson,Cyrille Touzeau,Niels Abildgaard,Evangelos Terpos,Roy Heusschen,Enrique M. Ocio,Michel Delforge,O. Sezer,Meral Beksac,Heinz Ludwig,Giampaolo Merlini,Philippe Moreau,Sonja Zweegman,Monika Engelhardt,Laura Rosiñol +19 more
TL;DR: A panel of expert European hematologists updates the recommendations on the diagnosis and management of patients with solitary plasmacytoma.
Journal ArticleDOI
Plasma cell myeloma and related neoplasms.
TL;DR: Based on the cases submitted to the workshop, common diagnostic issues and unusual manifestations of plasma cell neoplasms, such as t(11;14)+ PCM, plasma cell leukemia, and nonsecretory plasmacytoma are highlighted, as well as plasmablastic transformation of PCM.
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