Journal ArticleDOI
Prosocial effects of oxytocin and clinical evidence for its therapeutic potential.
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TLDR
The main focus of this review will be to summarize human preclinical work and particularly the rapidly growing number of clinical studies which have identified important links between oxytocin and a wide range of psychiatric disorders, and have now started to directly assess its therapeutic potential.About:
This article is published in Frontiers in Neuroendocrinology.The article was published on 2011-10-01. It has received 263 citations till now. The article focuses on the topics: Oxytocin receptor & Prosocial behavior.read more
Citations
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Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors
Inga D. Neumann,Rainer Landgraf +1 more
TL;DR: Shifting the balance between the neuropeptide systems towards oxytocin, by positive social stimuli and/or psychopharmacotherapy, may help to improve emotional behaviors and reinstate mental health.
Федеральное государственное бюджетное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний» Сибирского отделения Российской академии медицинских наук, Кемерово, Россия
S. V. Ivanov,A. N. Sumin,Y. V. Kazachek,D. E. Philipiev,S. M. Gusev,E. S. Malyshenko,L. S. Barbarash +6 more
TL;DR: The outcomes of CAD surgical treatment were improved in this group of patients due to the implementation of a mul-assisted revascularization of coronary and non-coronary arteries.
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The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences.
Miranda Olff,Jessie L. Frijling,Laura D. Kubzansky,Bekh Bradley,Mark A. Ellenbogen,Christopher Cardoso,Jennifer A. Bartz,Jason R. Yee,Mirjam van Zuiden +8 more
TL;DR: These studies in pre-clinical animal, healthy humans and patients samples further reinforce the importance of considering both contextual and interindividual factors when trying to understand the role of oxytocin as a biological substrate underlying social bonding and stress regulatory processes.
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Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
TL;DR: The data provide the first evidence that nasally applied OXT indeed reaches behaviorally relevant brain areas, and this uptake is paralleled by changes in plasma OXT.
Journal ArticleDOI
Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans
Nadine Striepens,Keith M. Kendrick,Vanessa Hanking,Rainer Landgraf,Ullrich Wüllner,Wolfgang Maier,Wolfgang Maier,René Hurlemann +7 more
TL;DR: Combined blood and cerebrospinal fluid sampling in subjects receiving either 24 IU of oxytocin or placebo is shown to show that oxytocIn levels significantly increased in both plasma and CSF, however, whereas Oxytocin plasma concentrations peaked at 15 min after intranasal administration and decreased after 75’�min, CSF concentrations took up to 75”min to reach a significant level.
References
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Central nervous system control of food intake
TL;DR: A model is described that delineates the roles of individual hormonal and neuropeptide signalling pathways in the control of food intake and the means by which obesity can arise from inherited or acquired defects in their function.
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Oxytocin increases trust in humans
TL;DR: It is shown that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions.
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Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
TL;DR: Oxytocin seems to enhance the buffering effect of social support on stress responsiveness, concur with data from animal research suggesting an important role of oxytocin as an underlying biological mechanism for stress-protective effects of positive social interactions.
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Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Peter Kirsch,Christine Esslinger,Qiang Chen,Daniela Mier,Stefanie Lis,Sarina Siddhanti,Harald Gruppe,Venkata S. Mattay,Bernd Gallhofer,Andreas Meyer-Lindenberg +9 more
TL;DR: It is shown that human amygdala function is strongly modulated by oxytocin, and this results indicate a neural mechanism for the effects of Oxytocin in social cognition in the human brain and provide a methodology and rationale for exploring therapeutic strategies in disorders in which abnormal amygdala function has been implicated, such as social phobia or autism.
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Sniffing neuropeptides: a transnasal approach to the human brain
TL;DR: Three peptides were administered intranasally and found that they achieved direct access to the cerebrospinal fluid (CSF) within 30 minutes, bypassing the bloodstream.