Protection from renal ischemia-reperfusion injury by the 2-methylaminochroman U83836E
Elena De Vecchi,Lorenzo Lubatti,Claudio Beretta,Stefano Ferrero,Paola Rinaldi,Marzia Galli Kienle,Rinaldo Trazzi,Rita Paroni +7 more
TLDR
There is a protective effect of U83836E in ischemia-reperfusion injury, in that tissue damage due to oxidative stress is reduced, thus ameliorating renal function impairment.About:
This article is published in Kidney International.The article was published on 1998-09-01 and is currently open access. It has received 27 citations till now. The article focuses on the topics: Kidney & Kidney disease.read more
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Journal ArticleDOI
Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.
TL;DR: Two representative compounds from a novel chemical series of potent inhibitors of lipid peroxidation are described and one of the compounds, U74500A, may act as a membrane localized chelator of iron.
Journal ArticleDOI
The morphology of "acute tubular necrosis" in man: analysis of 57 renal biopsies and a comparison with the glycerol model.
TL;DR: The glycerol model of acute renal failure in the rabbit was found to differ in several significant ways from ATN in man and may have an entirely different pathogenesis.
Journal ArticleDOI
The cell biology of ischemic renal injury
TL;DR: Most currently available data are pertinent to understanding the early events at the tubule cell level, and this information will necessarily comprise most of the review.
Journal ArticleDOI
21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils.
TL;DR: It is shown that U74006F can improve survival and attenuate neuronal necrosis in a severe brain ischemia model and comparison of neuronal densities in the ischemic hemisphere with those in the contralateral nonischemic hemisphere revealed significant neuronal preservation.
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