Protection from renal ischemia-reperfusion injury by the 2-methylaminochroman U83836E
Elena De Vecchi,Lorenzo Lubatti,Claudio Beretta,Stefano Ferrero,Paola Rinaldi,Marzia Galli Kienle,Rinaldo Trazzi,Rita Paroni +7 more
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TLDR
There is a protective effect of U83836E in ischemia-reperfusion injury, in that tissue damage due to oxidative stress is reduced, thus ameliorating renal function impairment.About:
This article is published in Kidney International.The article was published on 1998-09-01 and is currently open access. It has received 27 citations till now. The article focuses on the topics: Kidney & Kidney disease.read more
Citations
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Journal ArticleDOI
Possible Protective Potential of Atorvastatin and Black Seed (Nigella Sativa) Oil in Amikacin induced Nephrotoxicity in Adult Male Albino Rats
TL;DR: The present results indicate that the combination of ATO and NSO significantly minimizes AMK-induced nephrotoxicity in albino rats, may be due to their antioxidant properties.
Journal ArticleDOI
Morphological Changes Produced by Aminoglycoside Induced Nephrotoxicity - An Experimental Study
TL;DR: It is concluded that Aminoglycosides cause nephrotoxicity by producing damaging effects on renal tubules especially at higher does, so their administration should carefully be monitored for early detection and prevention of toxic effects.
Journal ArticleDOI
Renal ischemia/reperfusion injury inhibits differentiation of dendritic cells derived from bone marrow monocytes in rats.
Chih Jen Wu,Joen Rong Sheu,Han Hsiang Chen,Han Hsiang Chen,Hui-Fen Liao,Hui-Fen Liao,Yuh Cheng Yang,Stone Yang,Yu-Jen Chen +8 more
TL;DR: I/R stress reduces the number of DCs differentiated from bone marrow monocytes but not the functional activity of these DCs, and immunohistochemistry showed infiltrating DCs in the outer medulla of the I/R injured kidney at 2 d but not 14 d of reperfusion, suggesting a stress-induced downshift in the capacity of BMMos to differentiate into DCs and a parallel upshift to infiltrate the kidney.
Journal ArticleDOI
Lazaroid U-83836E improves tolerance to hemorrhagic shock and limb ischemia and reperfusion in rats and increases cardiac heat shock protein 72
TL;DR: Pretreatment with the lazaroid U-83836E improved mean arterial blood pressure after hemorrhagic shock and fluid resuscitation and increased expression of heat shock proteins of the 72-kDa family, causing observed protection of organs from ischemia-reperfusion damage.
Journal ArticleDOI
Protective effects of the BuOH fraction from mustard leaf in a renal ischemia-reperfusion model.
TL;DR: The results suggest that the BuOH fraction has protective effects against ischemia-reperfusion injury, acting as an antioxidant by scavenging O2-, inhibiting O2- generation through XOD, protecting against lipid peroxidation and ameliorating renal functional impairment.
References
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Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.
TL;DR: Two representative compounds from a novel chemical series of potent inhibitors of lipid peroxidation are described and one of the compounds, U74500A, may act as a membrane localized chelator of iron.
Journal ArticleDOI
The morphology of "acute tubular necrosis" in man: analysis of 57 renal biopsies and a comparison with the glycerol model.
TL;DR: The glycerol model of acute renal failure in the rabbit was found to differ in several significant ways from ATN in man and may have an entirely different pathogenesis.
Journal ArticleDOI
The cell biology of ischemic renal injury
TL;DR: Most currently available data are pertinent to understanding the early events at the tubule cell level, and this information will necessarily comprise most of the review.
Journal ArticleDOI
21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils.
TL;DR: It is shown that U74006F can improve survival and attenuate neuronal necrosis in a severe brain ischemia model and comparison of neuronal densities in the ischemic hemisphere with those in the contralateral nonischemic hemisphere revealed significant neuronal preservation.
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