Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling.
Mark P. Jedrychowski,Carlos A. Gartner,Steven P. Gygi,Li Zhou,Joachim Herz,Konstantin V. Kandror,Paul F. Pilch +6 more
Reads0
Chats0
TLDR
LRP1 (low density lipoprotein receptor-related protein 1) was identified as a major constituent of GSVs, and it is shown it interacts with the lumenal domains of GLUT4 and other GSV constituents.About:
This article is published in Journal of Biological Chemistry.The article was published on 2010-01-01 and is currently open access. It has received 127 citations till now. The article focuses on the topics: Vesicle & Insulin receptor.read more
Citations
More filters
Journal ArticleDOI
Regulation of glucose transport by insulin: traffic control of GLUT4
Dara Leto,Alan R. Saltiel +1 more
TL;DR: New insights into insulin signalling reveal that phosphorylation events initiated by the insulin receptor regulate key GLUT4 trafficking proteins, including small GTPases, tethering complexes and the vesicle fusion machinery.
Journal ArticleDOI
Regulation of glucose transporter translocation in health and diabetes.
TL;DR: Knowledge of how signaling and trafficking pathways are coordinated will be essential to understanding the pathogenesis of diabetes and the metabolic syndrome and may also inform a wide range of other physiologies.
Journal ArticleDOI
Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action
Javier R. Jaldin-Fincati,Martin Alejandro Pavarotti,Scott Frendo-Cumbo,Philip J. Bilan,Amira Klip +4 more
TL;DR: Recent findings on Akt-targeted Rab GTPase-activating proteins (GAPs) and downstream Rab G TPases along with the input of Rac1 and actin filaments reveal novel events in insulin-regulated GLUT4 traffic.
Journal ArticleDOI
Thirty sweet years of GLUT4.
TL;DR: The discovery of the insulin-responsive glucose transporter type 4 (GLUT4) protein in 1988 inspired its molecular cloning in the following year and spurred numerous cellular mechanistic studies laying the foundations for how insulin regulates glucose uptake by muscle and fat cells.
Journal ArticleDOI
Amyloid efflux transporter expression at the blood-brain barrier declines in normal aging.
Gerald D. Silverberg,Arthur Messier,Miles C. Miller,Jason T. Machan,Samir Majmudar,Edward G. Stopa,John E. Donahue,Conrad E. Johanson +7 more
TL;DR: In this article, the authors measured LRP-1 and P-gp expression and associated transporter expression with amyloid β peptides (Aβ) accumulation in Alzheimer disease in aging rats.
References
More filters
Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Quantitative analysis of complex protein mixtures using isotope-coded affinity tags
TL;DR: An approach for the accurate quantification and concurrent sequence identification of the individual proteins within complex mixtures based on isotope-coded affinity tags and tandem mass spectrometry is described.
Journal ArticleDOI
Signals for Sorting of Transmembrane Proteins to Endosomes and Lysosomes
TL;DR: This work has shown that peptide motifs serve as a signal for sorting at various stages of the endosomal-lysosomal system and several proteins, including clathrin, AP-2, and Dab2, have been proposed to function as recognition proteins for NPXY signals.
Journal ArticleDOI
The GLUT4 Glucose Transporter
Shaohui Huang,Michael P. Czech +1 more
TL;DR: This review focuses on recent advances on the biology of GLUT4, the principal glucose transporter protein that mediates glucose uptake into skeletal muscle and plays a key role in regulating whole body glucose homeostasis.