Pseudouridines in RNAs: switching atoms means shifting paradigms.
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TLDR
Pseudouridine (Ψ) is one of the most abundant post-transcriptional RNA base modifications and has been detected at individual positions in tRNAs, rRNs, mRNAs and snRNAs as discussed by the authors.About:
This article is published in FEBS Letters.The article was published on 2021-09-01 and is currently open access. It has received 10 citations till now. The article focuses on the topics: Small nucleolar RNA & Pseudouridine.read more
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Two years into COVID-19 - Lessons in SARS-CoV-2 and a perspective from papers in FEBS Letters.
TL;DR: The 2019 outbreak of coronavirus disease (COVID-19) in Wuhan (Hubei province of China) has given rise to a pandemic spread of virus, more than 240 million incidences and a death toll larger than 5 million people as mentioned in this paper.
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Techniques to detect epitranscriptomic marks.
TL;DR: An overview of the development of detection techniques for epitranscriptomic marks is presented and updates recent progress on the related field.
Peer Review
Two years into COVID‐19 – Lessons in SARS‐CoV‐2 and a perspective from papers in FEBS Letters
TL;DR: The recent COVID-19 papers are highlighted, and their implications towards understanding the molecular, biochemical and cellular mechanisms of SARS-CoV-2 infections, vaccine development and antiviral discovery strategies are discussed.
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Destabilization of mutated human PUS3 protein causes intellectual disability
Ting-Yu Lin,Robert Smigiel,Bozena Kuzniewska,Joanna J. Chmielewska,Joanna Kosińska,Mateusz Biela,Anna Biela,A. Koscielniak,Dominika Dobosz,Izabela Laczmanska,A. Chramiec-Glabik,Jakub Jeżowski,Jakub Stanislaw Nowak,Monika Gos,Sylwia Rzońca-Niewczas,Magdalena Dziembowska,Rafał Płoski,Sebastian Glatt +17 more
TL;DR: Exome sequencing is utilized to identify genomic variants that lead to a homozygous amino acid substitution in human PUS3 of two affected individuals and a compound heterozygous substitution in a third patient, providing a molecular explanation for the observed clinical phenotypes.
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The diverse structural modes of tRNA binding and recognition.
Anna Biela,Alexander Hammermeister,Igor Kaczmarczyk,Marta Walczak,Ting-Yu Lin,Sebastian Glatt +5 more
TL;DR: In this article , the authors summarize the most recent developments in the field to understand how three-dimensional structure affects the canonical and non-canonical functions of transfer RNAs, and they aim to summarize their most recent work.
References
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Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
James D. Watson,Francis Crick +1 more
TL;DR: The determination in 1953 of the structure of deoxyribonucleic acid (DNA), with its two entwined helices and paired organic bases, was a tour de force in X-ray crystallography and opened the way for a deeper understanding of perhaps the most important biological process.
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Dynamic RNA Modifications in Gene Expression Regulation
TL;DR: Roles for mRNA modification in nearly every aspect of the mRNA life cycle, as well as in various cellular, developmental, and disease processes are revealed.
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Compilation of tRNA sequences and sequences of tRNA genes
TL;DR: Alignment of the sequences, which is most compatible with the tRNA phylogeny and known three-dimensional structures of tRNA, is used.
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Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA
TL;DR: It is concluded that nucleoside modifications suppress the potential of RNA to activate DCs, and the innate immune system may detect RNA lacking nucleosides modification as a means of selectively responding to bacteria or necrotic tissue.
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MODOMICS: a database of RNA modification pathways. 2017 update.
Pietro Boccaletto,Magdalena A. Machnicka,Magdalena A. Machnicka,Elzbieta Purta,Pawel Piatkowski,Błażej Bagiński,Tomasz K Wirecki,de Crécy-Lagard,Robert L. Ross,Patrick A. Limbach,Annika Kotter,Mark Helm,Janusz M. Bujnicki,Janusz M. Bujnicki +13 more
TL;DR: In the current database version of MODOMICS, the following new features and data are included: extended mass spectrometry and liquid chromatography data for modified nucleosides; links between human tRNA sequences and MINTbase - a framework for the interactive exploration of mitochondrial and nuclear tRNA fragments.