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Psychological Stress as a Risk Factor for Cardiovascular Disease: A Case-Control Study.

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TLDR
Psychological stress is an important risk for cardiovascular disease, which is often overlooked and efforts should be made to include questions related to psychological stress in the history-taking of patients at risk of a cardiovascular event.
Abstract
Introduction Stress is a phenomenon elicited in response to certain triggers that may be external or internal. Stress has been identified as a risk factor for various diseases, including cardiovascular disease. In this study, we aim to find an association between psychological stress and cardiovascular disease in the local setting Methods This case-control study was conducted in a tertiary care hospital in Pakistan from June 2019 to December 2019. One hundred and seventeen (117) patients with myocardial infarction and unstable angina were enrolled in the case group. One hundred and ten (110) patient's attendants were enrolled in the study as controlled. Results The risk of a cardiovascular event was higher in patients with a history of social isolation (OR, 2.47), marital stress (OR, 2.28), work stress (OR, 3.2), childhood abuse (OR, 2.78), or trauma (OR, 2.67). Conclusion Psychological stress is an important risk for cardiovascular disease, which is often overlooked. Efforts should be made to include questions related to psychological stress in the history-taking of patients at risk of a cardiovascular event and the management plan should include psychological counseling.

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The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models.

TL;DR: The recent change in keloid nomenclature will be discussed, which has moved away from identifying keloids solely as abnormal scars with a purely cosmetic association toward understanding keloidal for the fibroproliferative disorder that they are.
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Dysregulated haemostasis in thrombo-inflammatory disease

TL;DR: In this paper , the detailed cellular and biochemical mechanisms that cause inflammation-driven haemostatic dysregulation, including aberrant contact pathway activation, increased tissue factor activity and release, innate immune cell activation and programmed cell death, and T cell-mediated changes in thrombus resolution, are described.
Journal ArticleDOI

Dysregulated haemostasis in thrombo-inflammatory disease

- 01 Dec 2022 - 
TL;DR: In this article , the detailed cellular and biochemical mechanisms that cause inflammation-driven haemostatic dysregulation, including aberrant contact pathway activation, increased tissue factor activity and release, innate immune cell activation and programmed cell death, and T cell-mediated changes in thrombus resolution, are described.
References
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Journal ArticleDOI

Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels

TL;DR: Pravastatin therapy reduced mortality from coronary heart disease and overall mortality, as compared with the rates in the placebo group, as well as the incidence of all prespecified cardiovascular events in patients with a history of myocardial infarction or unstable angina who had a broad range of initial cholesterol levels.
Journal ArticleDOI

Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 13 648 controls from 52 countries (the INTERHEART study): case-control study

TL;DR: Significant differences in the relation of psychosocial factors to risk of myocardial infarction in 24767 people from 52 countries were found, suggesting that approaches aimed at modifying these factors should be developed.
Journal ArticleDOI

Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear

TL;DR: Electrolytic and ibotenic acid lesions of the LH demonstrate that neurons in the LH are involved in the autonomic, but not the behavioral, conditioned response pathway, whereas neurons inThe caudal CG are involvedIn the behavioral and autonomic pathway, although different efferent projections of the central amygdala thus appear to mediate the behavioraland autonomic concomitants of conditioned fear.
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