Journal ArticleDOI
Pyrano chalcones and a flavone from Neoraputia magnifica and their Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase-inhibitory activities.
Daniela M. Tomazela,Mônica Tallarico Pupo,Edna A. P. Passador,M. Fátima das G. F. da Silva,Paulo C. Vieira,João B. Fernandes,Edson Rodrigues Fo,Glaucius Oliva,José Rubens Pirani +8 more
TLDR
The fruits of Neoraptua magnifica afforded three new flavonoids: 2'-hydroxy-4,4',-dimethoxy-5',6'-(2'',2''-dimethylpyrano)chalcone, and 3',4'-methylenedioxy-5,6,7-trimethoxyflavone, which were identified on the basis of spectroscopic methods.About:
This article is published in Phytochemistry.The article was published on 2000-11-01. It has received 74 citations till now. The article focuses on the topics: Chalcone.read more
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A critical review on Chagas disease chemotherapy.
TL;DR: A historical introduction of drugs assayed against Chagas disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental use of nitrofurazone, and a survey about new classes of synthetic and natural compounds studied after 1992/1993.
Journal ArticleDOI
Natural and synthetic chromenes, fused chromenes, and versatility of dihydrobenzo[h]chromenes in organic synthesis.
Ramendra Pratap,Vishnu Ji Ram +1 more
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The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases – Part I
Thomas J. Schmidt,Sami A. Khalid,Alvaro J. Romanha,T. Ma. Alves,Maique W. Biavatti,Reto Brun,FB Da Costa,S. L. De Castro,Vitor F. Ferreira,M. V. G. de Lacerda,João Henrique G. Lago,Leonor L. Leon,Norberto Peporine Lopes,R. C. das Neves Amorim,Michael Niehues,Ifedayo Victor Ogungbe,Adrian Martin Pohlit,Marcus Tullius Scotti,William N. Setzer,M. de N. C. Soeiro,M. Steindel,Andre G. Tempone +21 more
TL;DR: The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs.
Journal ArticleDOI
Naturally occurring chalcones and their biological activities
Zsuzsanna Rozmer,Pál Perjési +1 more
TL;DR: The aim of this review is to summarize the various naturally occurring chalcone compounds which have been isolated from different plants to initiate further pharmacobotanical, biotechnological and medicinal studies on the field of chal cone research.
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Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives
TL;DR: A comprehensive study of the structural features of anti-infective chalcones, their mechanism of actions (MOAs) and structure activity relationships (SARs) have been highlighted and may be helpful for (medicinal) chemists to design more potent, safe, selective and cost effective anti- Infective agents.
References
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Journal Article
Carbon-13 NMR of flavonoids
TL;DR: Agrawal et al. as mentioned in this paper proposed a method for signal assignment of carbon-13 NMR spectroscopy images of the flavonoid structures and established the aromatic substitution pattern.
Journal ArticleDOI
Gradient-enhanced heteronuclear correlation spectroscopy: Theory and experimental aspects
Jesús Ruiz-Cabello,Geerten W. Vuister,Chrit T. W. Moonen,Peter van Gelderen,Jack S. Cohen,Peter C. M. van Zijl +5 more
TL;DR: In this article, a detailed theoretical and experimental treatment for gradientenhanced heteronuclear correlation spectroscopy is given for both multiple-quantum and singlequantum sequences are described.
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Two new polymethoxylated flavones, a class of compounds with potential anticancer activity, isolated from cold pressed Dancy tangerine peel oil solids.
TL;DR: In this paper, ten polymethoxylated flavonoids were isolated and characterized from cold pressed tangerine oil solids; they are 5,6,7,3,4,4‘-pentamethoxyflavone (sinensetin) (I); 7-hydroxy-3,5, 6,3-6,3‘,4' -pentametin (tangeretin)(V); 5,7-8,4-4'-tetramethioxylated flavone
Journal ArticleDOI
Chemosystematics of the Rutaceae: suggestions for a more natural taxonomy and evolutionary interpretation of the family
TL;DR: The chemosystematics of Rutaceae is reviewed on the basis of updated surveys of various secondary metabolites and their biosynthetic derivation, and a stepwise replacement of benzylisoquinolines by simple and complex anthranilic acid derived alkaloids, and eventually by coumarins and/or limonoids is confirmed.
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Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase: structure, catalytic mechanism and targeted inhibitor design.
Dulce Helena Ferreira de Souza,Richard Charles Garratt,Ana Paula Ulian de Araújo,Beatriz G. Guimarães,W D P Jesus,Paulus Michels,Véronique Hannaert,Glaucius Oliva +7 more
TL;DR: Comparison with the human enzyme indicates that interfering with this salt bridge could be a new approach to specific inhibitor design, as the equivalent to Asp210 is a leucine in the mammalian enzymes.