Journal ArticleDOI
Quercetin induces apoptosis via the mitochondrial pathway in KB and KBv200 cells.
TLDR
Quercetin was found to induce apoptosis in KB and KBv200 cells via the mitochondrial pathway, including a decrease of the reactive oxygen species level, loss of mitochondrial membrane potential, release of cytochrome c, activation of caspase-9 and caspases-3, and cleavage of poly (ADP-ribose) polymerase.Abstract:
In this study, anticancer activities of six compounds of flavonoids were investigated in human epidermoid carcinoma KB and KBv200 cells. Among these compounds, quercetin and acacetin showed strong inhibition of cell growth in KB and KBv200 cells. IC50 values of quercetin against KB and KBv200 cells were 17.84 ± 4.14 and 18.94 ± 4.75 μM, respectively. The IC50 values of acacetin against KB and KBv200 cells were 41.33 ± 6.05 and 49.04 ± 3.64 μM. The IC50 values of apigenin, kaempferol, kaempferol 3-O-rhamnoside, and quercetin 3-O-rhamnoside were more than 100 μM. Furthermore, quercetin was found to induce apoptosis in KB and KBv200 cells via the mitochondrial pathway, including a decrease of the reactive oxygen species level, loss of mitochondrial membrane potential, release of cytochrome c, activation of caspase-9 and caspase-3, and cleavage of poly (ADP-ribose) polymerase. The apoptosis induced by quercetin was not related to the regulation of Bcl-2 or Bax in KB and KBv200 cells.read more
Citations
More filters
Journal ArticleDOI
Polyphenols and mitochondria: An update on their increasingly emerging ROS-scavenging independent actions
TL;DR: By acting on such mitochondrial processes, polyphenols may afford protection against those mitochondrial damaging events that appear to be key in the cellular toxicity induced by various xenobiotics as well as that seen during the development of several ROS-related diseases.
Journal ArticleDOI
The effects of bioactive compounds from plant foods on mitochondrial function: a focus on apoptotic mechanisms.
Tamara Y. Forbes-Hernandez,Francesca Giampieri,Massimiliano Gasparrini,Luca Mazzoni,José L. Quiles,José M. Alvarez-Suarez,Maurizio Battino +6 more
TL;DR: This review summarizes and updates the most recent findings concerning the mechanisms through which different dietary compounds from plant foods affect mitochondria functionality in healthy and pathological in vitro and in vivo models, paying particular attention to the pathways involved in mitochondrial biogenesis and apoptosis.
Journal ArticleDOI
Quercetin and the mitochondria: A mechanistic view
Marcos Roberto de Oliveira,Seyed Mohammad Nabavi,Nady Braidy,William N. Setzer,Touqeer Ahmed,Seyed Fazel Nabavi +5 more
TL;DR: Recent evidence on the ability of quercetin to interact with the abovementioned pathways is evaluated, and critically analyses how, such interactions can exert protection against mitochondrial damage in response to toxicity induced by several exogenously and endogenously-produced cellular stressors, and oxidative stress in particular.
Journal ArticleDOI
Quercetin in Cancer Treatment, Alone or in Combination with Conventional Therapeutics?
Ana Brito,Marina Ribeiro,Ana M. Abrantes,Ana Salomé Pires,Ricardo Teixo,José Guilherme Tralhão,Maria Filomena Botelho +6 more
TL;DR: This review is focused on the relationship between flavonoids and cancer, with special emphasis on the role of quercetin, which has diverse biological effects, inhibiting multiple enzymes involved in cell proliferation, as well as, in signal transduction pathways.
Journal ArticleDOI
Copper induces oxidative stress and apoptosis through mitochondria-mediated pathway in chicken hepatocytes.
Fan Yang,Ruonan Pei,Zhuowei Zhang,Jianzhao Liao,Wenlan Yu,Na Qiao,Qingyue Han,Ying Li,Lianmei Hu,Jianying Guo,Jiaqiang Pan,Zhaoxin Tang +11 more
TL;DR: It is suggested that excessive Cu could induce oxidative stress and apoptosis via mitochondrial pathway in chicken hepatocytes in a dose effect.
References
More filters
Journal Article
The Antitumor Activities of Flavonoids
Chithan Kanadaswami,Lung Ta Lee,Ping Ping H. Lee,Jiuan Jiuan Hwang,Ferng Chun Ke,Ying Tung Huang,Ming Ting Lee +6 more
TL;DR: Experimental animal studies indicate that certain dietary flavonoids possess antitumor activity, and the hydroxylation pattern of the B ring of the flavones and flavonols seems to critically influence their activities, especially the inhibition of protein kinase activity and antiproliferation.
Journal ArticleDOI
Tissue Distribution of Quercetin in Rats and Pigs
Vincent C. J. de Boer,Ashwin A. Dihal,Hester van der Woude,Ilja C. W. Arts,Siegfried Wolffram,Gerrit M. Alink,Ivonne M.C.M. Rietjens,Jaap Keijer,Peter C. H. Hollman +8 more
TL;DR: These studies have for the first time identified target tissues of quercetin, which may help to understand its mechanisms of action in vivo, and identify its availability to tissues.
Journal ArticleDOI
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
TL;DR: Data indicate that quercetin exerts anti-adipogenesis activity by activating the AMPK signal pathway in 3T3-L1 preadipocytes, while the quercETin-induced apoptosis of mature adipocytes was mediated by modulation of the ERK and JNK pathways, which play pivotal roles during apoptosis.
Journal ArticleDOI
Quercetin Induces Apoptosis via Caspase Activation, Regulation of Bcl-2, and Inhibition of PI-3-Kinase/Akt and ERK Pathways in a Human Hepatoma Cell Line (HepG2)
TL;DR: It is suggested that quercetin may induce apoptosis by direct activation of caspase cascade (mitochondrial pathway) and by inhibiting survival signaling in HepG2.
Journal ArticleDOI
Which Sources of Flavonoids: Complex Diets or Dietary Supplements?
Sarah Egert,Gerald Rimbach +1 more
TL;DR: It needs to be critically evaluated whether vascular health-promoting and other positive properties of flavonoid-rich diets can be replaced by purified flavonoids as dietary supplements.