Rabbit Hepatitis E Virus Infections in Humans, France.
Florence Abravanel,Sébastien Lhomme,Hicham El Costa,Betoul Schvartz,Jean-Marie Péron,Nassim Kamar,Jacques Izopet +6 more
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TLDR
Of 919 HEV-infected patients in France during 2015–2016, five were infected with a rabbit HEV strain; none of the patients had direct contact with rabbits, suggesting foodborne or waterborne infections.Abstract:
Hepatitis E virus (HEV) has been detected in rabbits, but whether rabbit HEV strains can be transmitted to humans is not known. Of 919 HEV-infected patients in France during 2015-2016, five were infected with a rabbit HEV strain. None of the patients had direct contact with rabbits, suggesting foodborne or waterborne infections.read more
Citations
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Insertions and Duplications in the Polyproline Region of the Hepatitis E Virus.
Sébastien Lhomme,Florence Nicot,Nicolas Jeanne,Chloé Dimeglio,Alain Roulet,Caroline Lefebvre,Romain Carcenac,Maxime Manno,Martine Dubois,Jean-Marie Péron,Laurent Alric,Nassim Kamar,Florence Abravanel,Florence Abravanel,Jacques Izopet,Jacques Izopet +15 more
TL;DR: This is the first description of HEV strains with genomic rearrangements in patients at the acute phase of infection; perhaps these strains are directly transmitted.
Journal ArticleDOI
EASL Clinical Practice Guidelines on hepatitis E virus infection
Harry R. Dalton,Nassim Kamar,Sally A. Baylis,Darius Moradpour,Heiner Wedemeyer,Francesco Negro +5 more
TL;DR: These Clinical Practice Guidelines will be on HEV genotype 3 (and 4) and show that locally acquired HEV is now the commonest cause of acute viral hepatitis in many European countries.
Journal ArticleDOI
Hepatitis E virus infection.
Nassim Kamar,Jacques Izopet,Nicole Pavio,Rakesh Aggarwal,Alain B. Labrique,Heiner Wedemeyer,Harry R. Dalton +6 more
TL;DR: HEV infections can be diagnosed by measuring anti-HEV antibodies, HEV RNA or viral capsid antigen in blood or stool and management of immunocompromised individuals involves lowering the dose of immunosuppressive drugs and/or treatment with the antiviral agent ribavirin.
Journal ArticleDOI
Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant.
Siddharth Sridhar,Cyril C. Y. Yip,Shusheng Wu,Jian-Piao Cai,Anna Jinxia Zhang,Kit-Hang Leung,Tom Wai-Hin Chung,Jasper Fuk-Woo Chan,Wan-Mui Chan,Jade L. L. Teng,Rex Au-Yeung,Vincent C.C. Cheng,Honglin Chen,Susanna K. P. Lau,Patrick C. Y. Woo,Ningshao Xia,Chung Mau Lo,Kwok-Yung Yuen +17 more
TL;DR: Treatment with Ribavirin was an effective treatment, resulting in resolution of hepatitis and clearance of HEV-C viremia, and testing for this zoonotic virus should be performed for Immunocompromised and immunocompetent patients with unexplained hepatitis.
Journal ArticleDOI
Public health risks associated with hepatitis E virus (HEV) as a food‐borne pathogen
Antonia Ricci,Ana Allende,Declan Bolton,Marianne Chemaly,Robert Davies,Pablo Salvador Fernández Escámez,Lieve Herman,Kostas Koutsoumanis,Roland Lindqvist,Birgit Nørrung,Lucy J. Robertson,Giuseppe Ru,Moez Sanaa,Marion Simmons,Panagiotis N. Skandamis,Emma Snary,Niko Speybroeck,Benno H. ter Kuile,John Threlfall,Helene Wahlström,Ilaria Di Bartolo,Reimar Johne,Nicole Pavio,Saskia A. Rutjes,Wim H.M. van der Poel,Petra Vasickova,Michaela Hempen,Winy Messens,Valentina Rizzi,Francesca Latronico,Rosina Girones +30 more
TL;DR: The opinion reviews current methods for the detection, identification, characterisation and tracing of HEV in food‐producing animals and foods, reviews literature on HEV reservoirs and food‐borne pathways, examines information on the epidemiology ofHEV and its occurrence and persistence in foods, and investigates possible control measures along the food chain.
References
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Journal ArticleDOI
Hepatitis E Virus Infection
Nassim Kamar,Nassim Kamar,Harry R. Dalton,Florence Abravanel,Florence Abravanel,Jacques Izopet,Jacques Izopet +6 more
TL;DR: In this comprehensive review, the current knowledge about the virus itself, as well as the epidemiology, diagnostics, natural history, and management of HEV infection in developing and developed countries are summarized.
Journal ArticleDOI
Ribavirin for Chronic Hepatitis E Virus Infection in Transplant Recipients
Nassim Kamar,Jacques Izopet,Simona Tripon,Michael Bismuth,Sophie Hillaire,Jérôme Dumortier,Sylvie Radenne,Audrey Coilly,Valérie Garrigue,Louis d’Alteroche,Matthias Büchler,Lionel Couzi,Pascal Lebray,Sébastien Dharancy,Anne Minello,Maryvonne Hourmant,Anne-Marie Roque-Afonso,Florence Abravanel,Stanislas Pol,Lionel Rostaing,Vincent Mallet +20 more
TL;DR: This retrospective, multicenter study showed that ribavirin as monotherapy may be effective in the treatment of chronic HEV infection; a 3-month course seemed to be an appropriate duration of therapy for most patients.
Journal ArticleDOI
Proposed reference sequences for hepatitis E virus subtypes
B. Douglas Smith,Peter Simmonds,Jacques Izopet,Edmilson Ferreira de Oliveira-Filho,Rainer G. Ulrich,Reimar Johne,Matthias Koenig,Shahid Jameel,Tim J. Harrison,Xiang-Jin Meng,Hiroaki Okamoto,Wim H.M. van der Poel,Michael A. Purdy +12 more
TL;DR: A table of proposed complete genome reference sequences for each hepatitis E virus subtype is provided to facilitate communication between researchers and help clarify the epidemiology of this important human pathogen.
Journal ArticleDOI
Hepatitis E virus strains in rabbits and evidence of a closely related strain in humans, France.
Jacques Izopet,Martine Dubois,Stéphane Bertagnoli,Sébastien Lhomme,Stéphane Marchandeau,Samuel Boucher,Nassim Kamar,Florence Abravanel,Jean-Luc Guérin +8 more
TL;DR: The host range ofHEV in Europe is expanding, and zoonotic transmission of HEV from rabbits is possible.
Journal ArticleDOI
A nationwide survey of hepatitis E viral infection in French blood donors.
Jean Michel Mansuy,Pierre Gallian,Chloé Dimeglio,Karine Sauné,Catherine Arnaud,B. Pelletier,Pascal Morel,Dominique Legrand,Pierre Tiberghien,Jacques Izopet +9 more
TL;DR: HEV is endemic in France and hyperendemic in some areas; eating habits alone cannot totally explain the exposure to HEV, and contaminated water could contribute to the epidemiology of HEV infection in France.