Journal ArticleDOI
Reaction of β-dimethylaminovinyl ketones with hydroxylamine: A simple and useful method for synthesis of 3- and 5-substituted isoxazoles
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TLDR
In this paper, the regioselective synthesis of 3 and 5-substituted isoxazoles from β-dimethyl-aminovinyl ketones was reported.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2008-05-01. It has received 33 citations till now. The article focuses on the topics: Hydroxylamine & Pyridine.read more
Citations
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Journal ArticleDOI
Arylglyoxals in synthesis of heterocyclic compounds.
Journal ArticleDOI
Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles.
TL;DR: A series of 3-substituted and 3,5-disubstituting isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with alpha,beta-unsaturated aldehydes/ketones.
Journal ArticleDOI
Efficient and Regioselective Synthesis of 5-Hydroxy-2-isoxazolines: Versatile Synthons for Isoxazoles, β-Lactams, and γ-Amino Alcohols
TL;DR: An efficient and highly regioselective protocol was developed for the preparation of 5-Hydroxy-2-isoxazolines, which have been proved to be versatile synthons for isoxazles, beta-hydroxy oximes, and gamma-amino alcohols.
Journal ArticleDOI
Synthesis of 3,5-Disubstituted Isoxazoles via Cope-Type Hydroamination of 1,3-Dialkynes
TL;DR: In this paper, an efficient method for the synthesis of 3,5-disubstituted isoxazoles was described, and the reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions.
Journal ArticleDOI
The intramolecular aryl embrace: from light emission to light absorption.
Biljana Bozic-Weber,Edwin C. Constable,Catherine E. Housecroft,Peter Kopecky,Markus Neuburger,Jennifer A. Zampese +5 more
TL;DR: Copper(I) complexes in which L is 2,2'-bipyridine substituted in the 6-position by furyl, thienyl, N-methylpyrrolyl, selenopheneyl, methyl or phenyl have been synthesized and the best efficiencies are observed for [CuLL'] with L' = 10 which contains phosphonate anchoring groups.
References
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4-Alkoxy-1,1,1-Trichloro-3-Alken-2-ones: Preparation and Applications in Heterocyclic Synthesis
Marcos A. P. Martins,Wilson Cunico,Claudio Martim Pereira de Pereira,Adilson P. Sinhorin,Alex F. C. Flores,Helio G. Bonacorso,Nilo Zanatta +6 more
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Novel two step synthesis of pyrazoles and isoxazoles from aryl methyl ketones
Yang-I Lin,S. A. Lang +1 more
TL;DR: In this article, masked β-ketoaldehydes were used to synthesize pyrazoles or isoxazoles, which can react with hydrazine hydrate or hydroxylamine at room temperature to give good yields.
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Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles.
TL;DR: In this article, the authors showed that 3-halo-4-,5-dihydroisoxazole containing compounds are selective inhibitors of human transglutaminase 2.
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Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.
Donald A. Patrick,Stanislav A. Bakunov,Svetlana M. Bakunova,E. V. K. Suresh Kumar,Richard J. Lombardy,Susan Jones,Arlene S. Bridges,Oksana Zhirnov,James Edwin Hall,Tanja Wenzler,Reto Brun,Richard R. Tidwell +11 more
TL;DR: 43 isoxazole derivatives were assayed against Trypanosoma brucei rhodesiense, and 14 of these compounds had cytotoxic indices ranging between 10 and 120 times higher than that of furamidine, and five analogues exhibited high selectivity for P. falciparum.