Recent Advances in the Discovery and Development of Plant-Derived Natural Coumarins and their Analogues as Anti Human Immunodeficiency Virus—Type 1 (HIV-1) Agents
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TLDR
The aim of this review is to summarize research findings for herbal medicines, especially coumarins, which are endowed with the ability to inhibit HIV.Abstract:
The acquired immunodeficiency syndrome (AIDS) is a result of human immunodeficiency virus (HIV) infection which leads to severe suppression of immune functions. AIDS is a real threat to the health of mankind, and the search for effective therapies is still of great importance. However, besides the high cost, there are adverse effects and limitations associated with chemotherapy applied. Thus, herbal medicines are frequently used as an alternative therapy by individuals living with HIV. Numerous plant-derived compounds have been evaluated for inhibitory effects on HIV replication, and many coumarins have been found to inhibit different steps in HIV replication cycle. The aim of this review is to summarize research findings for herbal medicines, especially coumarins, which are endowed with the ability to inhibit HIV.read more
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Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR).
TL;DR: In this article, a review of antibiotic resistance strategies produced by multidrug-resistant bacteria and phytochemicals from different classes with documented antimicrobial action against resistant bacteria, either alone or in combination with traditional antibiotics is presented.
Journal ArticleDOI
Biologically active coumarins as inhibitors of HIV-1
Irena Kostova,Jan Mojzis +1 more
TL;DR: The objective of this review is to evaluate data on coumarins’ potent activity with respect to the inhibition of HIV-reverse transcriptase, HIV-integrase or HIV-protease.
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Antihuman Immunodeficiency Virus Type 1 (HIV-1) Activity of Rare Earth Metal Complexes of 4-Hydroxycoumarins in Cell Culture
Ilia Manolov,S. Raleva,Petya Genova,Alexey Savov,Liliana Froloshka,Daniela Dundarova,Radka Argirova +6 more
TL;DR: The cerium Ce(III, lanthanum La(III), and neodymium Nd(III) complexes were synthesized and studied for the first time for cytotoxicity (on MT-2 cells) and as anti-HIV agents under acute and chronic infection.
Journal ArticleDOI
Reaction of P,P,P-trihalogenbenzo-1,3,2-dioxaphospholes with terminal acetylenes: Phosphorus-carbon bond formation and the ipso-substitution of oxygen by carbon
V. F. Mironov,A. V. Nemtarev +1 more
TL;DR: In this article, a new reaction in phosphorus chemistry, namely, the interaction of 2,2,2-trihalobenzo-1, 3, 2-dioxaphospholes with aryl(alkyl)acetylenes, leads to the formation of benzo[e]-1,2oxaphosphinine derivatives, or “phosphacoumarins.
Journal ArticleDOI
Reactions of Arylenedioxytrihalophosphoranes with Acetylenes: XV.1 Reaction of 2,2,2-Tribromo-4,6-di-tert-butylbenzo-1,3,2λ5-dioxaphospholedioxaphosphole with Pent-1-yne
A. V. Nemtarev,A. V. Nemtarev,Vladimir F. Mironov,Vladimir F. Mironov,Robert R. Fayzullin,Igor A. Litvinov,Rashid Z. Musin +6 more
TL;DR: In this article, the minor isomer was formed as a result of substitution of the oxygen atom in the ortho position with respect to one tert-butyl group of the initial phosphole.
References
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