Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration.
Kangkang Zha,Zhiqiang Sun,Zhiqiang Sun,Yu Yang,Mingxue Chen,Cangjiang Gao,Cangjiang Gao,Liwei Fu,Liwei Fu,Hao Li,Hao Li,Xiang Sui,Quanyi Guo,Shuyun Liu +13 more
TLDR
A review of recent advances in enhancement strategies for MSC chondrogenic differentiation, including optimization of bioactive factors, culture conditions, cell type selection, coculture, gene editing, scaffolds, and physical stimulation, can be found in this article.Abstract:
Articular cartilage is susceptible to damage, but its self-repair is hindered by its avascular nature. Traditional treatment methods are not able to achieve satisfactory repair effects, and the development of tissue engineering techniques has shed new light on cartilage regeneration. Mesenchymal stem cells (MSCs) are one of the most commonly used seed cells in cartilage tissue engineering. However, MSCs tend to lose their multipotency, and the composition and structure of cartilage-like tissues formed by MSCs are far from those of native cartilage. Thus, there is an urgent need to develop strategies that promote MSC chondrogenic differentiation to give rise to durable and phenotypically correct regenerated cartilage. This review provides an overview of recent advances in enhancement strategies for MSC chondrogenic differentiation, including optimization of bioactive factors, culture conditions, cell type selection, coculture, gene editing, scaffolds, and physical stimulation. This review will aid the further understanding of the MSC chondrogenic differentiation process and enable improvement of MSC-based cartilage tissue engineering.read more
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Magnetic Nanoparticles and Magnetic Field Exposure Enhances Chondrogenesis of Human Adipose Derived Mesenchymal Stem Cells But Not of Wharton Jelly Mesenchymal Stem Cells.
Luminita Labusca,Dumitru-Daniel Herea,Anca Emanuela Minuti,Cristina Stavila,Camelia Danceanu,Petru Plamadeala,Horia Chiriac,Nicoleta Lupu +7 more
TL;DR: In this paper, the authors investigated comparatively chondrogenic conversion of Adipose derived mesenchymal stem cells (ADSC) and WJMSC with or without Magnetic Field (MF) exposure.
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Thermo-Responsive Gel Containing Hydroxytyrosol-Chitosan Nanoparticles (Hyt@tgel) Counteracts the Increase of Osteoarthritis Biomarkers in Human Chondrocytes
Anna Valentino,Raffaele Conte,Ilenia De Luca,Francesca Di Cristo,Gianfranco Peluso,Michela Bosetti,Anna Calarco +6 more
TL;DR: The formulated hydrogel injection could be proposed for the efficient and sustained Hyt delivery for OA treatment and the next step would be the extraction of “added-value” bioactive polyphenols from by-products of the olive industry, in order to develop a green delivery system able to enhance the human wellbeing but also to promote a sustainable environment.
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Mesenchymal stem cells and their microenvironment
TL;DR: In this paper , Mesenchymal stem cells (MSCs) play vital roles in immunomodulation, hematopoiesis, and tissue repair, and the microenvironment of cells often refers to the intercellular matrix, other cells, cytokines and humoral components.
Journal ArticleDOI
Mesenchymal stem cells and their microenvironment
TL;DR: In this article , Mesenchymal stem cells (MSCs) play vital roles in immunomodulation, hematopoiesis, and tissue repair, and the microenvironment of cells often refers to the intercellular matrix, other cells, cytokines and humoral components.
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Fisetin Inhibits Osteogenic Differentiation of Mesenchymal Stem Cells via the Inhibition of YAP.
Chanchao Lorthongpanich,Thanapon Charoenwongpaiboon,Prapasri Supakun,Methus Klaewkla,Pakpoom Kheolamai,Surapol Issaragrisil +5 more
TL;DR: In this article, the effect of fisetin on the biological properties of human mesenchymal stem cells derived from chorion tissue and its role in human osteogenesis using MSCs and osteoblast-like cells (SaOs-2) as a model.
References
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A Stem Cell–Based Approach to Cartilage Repair
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PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages.
Felicia Soo Lee Ng,Shayne Boucher,Susie Koh,Konduru S. R. Sastry,Lucas G. Chase,Uma Lakshmipathy,Cleo Choong,Zheng Yang,Mohan C. Vemuri,Mahendra S. Rao,Vivek Tanavde +10 more
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