Regulation of flagellar motility during biofilm formation
TLDR
The regulation of motility during biofilm formation in Bacillus, Pseudomonas, Vibrio, and Escherichia is reviewed, and it is concluded that the motility-to-biofilm transition, if necessary, likely involves two steps.Abstract:
Many bacteria swim in liquid or swarm over solid surfaces by synthesizing rotary flagella The same bacteria that are motile also commonly form nonmotile multicellular aggregates called biofilms Biofilms are an important part of the lifestyle of pathogenic bacteria, and it is assumed that there is a motility-to-biofilm transition wherein the inhibition of motility promotes biofilm formation The transition is largely inferred from regulatory mutants that reveal the opposite regulation of the two phenotypes Here, we review the regulation of motility during biofilm formation in Bacillus, Pseudomonas, Vibrio, and Escherichia, and we conclude that the motility-to-biofilm transition, if necessary, likely involves two steps In the short term, flagella are functionally regulated to either inhibit rotation or modulate the basal flagellar reversal frequency Over the long term, flagellar gene transcription is inhibited and in the absence of de novo synthesis, flagella are diluted to extinction through growth Both short-term and long-term motility inhibition is likely important to stabilize cell aggregates and optimize resource investment We emphasize the newly discovered flagellar functional regulators and speculate that others await discovery in the context of biofilm formationread more
Citations
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Beyond Risk: Bacterial Biofilms and Their Regulating Approaches.
Musa Hassan Muhammad,Aisha Lawan Idris,Xiao Fan,Yachong Guo,Yiyan Yu,Xu Jin,Junzhi Qiu,Xiong Guan,Tianpei Huang +8 more
TL;DR: The events involved in bacterial biofilm formation are described, the negative and positive aspects associated with bacterial biofilms are listed, the main strategies currently used to regulate establishment of harmful bacterial bioFilms are elaborated as well as certain strategies employed to encourage formation of beneficial bacterialBiofilms.
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Biofilms, flagella, and mechanosensing of surfaces by bacteria
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The flagellum in bacterial pathogens: For motility and a whole lot more
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TL;DR: In this article, BslA (formerly YuaB) was identified as a major contributor to the surface repellency of Bacillus subtilis biofilms, which probably explains the broad-spectrum resistance of the bacteria in these bio-films to antimicrobial agents.
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Type III secretion systems: the bacterial flagellum and the injectisome
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References
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Polar and lateral flagellar motors of marine Vibrio are driven by different ion-motive forces
TL;DR: Evidence that two distinct types of flagella powered by different energy sources are functionally active in one cell is reported, showing that the energy source for the polar flagellar motor of Vibrio para-haemolyticus is the sodium-motive force, whereas the lateral flageLLar motors are driven by the proton-Motive force.
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BslA(YuaB) forms a hydrophobic layer on the surface of Bacillus subtilis biofilms
Kazuo Kobayashi,Megumi Iwano +1 more
TL;DR: It is proposed that BslA, standing for biofilm‐surface layer protein, is responsible for the hydrophobic layer on the surface of biofilms.
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Get the message out: cyclic-Di-GMP regulates multiple levels of flagellum-based motility
Alan J. Wolfe,Karen L. Visick +1 more
TL;DR: Flagella are complex organelles whose synthesis depends upon approximately 50 gene products and perhaps best understood is the control exerted at the level of the TSP.
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The novel sigma54- and sigma28-dependent flagellar gene transcription hierarchy of Vibrio cholerae.
TL;DR: A model of V. cholerae flagellar gene transcription as a novel hierarchy composed of four classes of genes is supported, which has incorporated elements from both the σ54‐dependent Caulobacter crescentus polar flagllar hierarchy and the ρ28‐dependent S. typhimurium peritrichous flageLLar hierarchy.
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Seiji Kojima,David F. Blair +1 more
TL;DR: It is proposed that the protons energizing the motor interact with Asp32 of MotB to induce conformational changes in the stator that drive movement of the rotor, consistent with a role in the generation of torque.
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