Regulation of flagellar motility during biofilm formation
TLDR
The regulation of motility during biofilm formation in Bacillus, Pseudomonas, Vibrio, and Escherichia is reviewed, and it is concluded that the motility-to-biofilm transition, if necessary, likely involves two steps.Abstract:
Many bacteria swim in liquid or swarm over solid surfaces by synthesizing rotary flagella The same bacteria that are motile also commonly form nonmotile multicellular aggregates called biofilms Biofilms are an important part of the lifestyle of pathogenic bacteria, and it is assumed that there is a motility-to-biofilm transition wherein the inhibition of motility promotes biofilm formation The transition is largely inferred from regulatory mutants that reveal the opposite regulation of the two phenotypes Here, we review the regulation of motility during biofilm formation in Bacillus, Pseudomonas, Vibrio, and Escherichia, and we conclude that the motility-to-biofilm transition, if necessary, likely involves two steps In the short term, flagella are functionally regulated to either inhibit rotation or modulate the basal flagellar reversal frequency Over the long term, flagellar gene transcription is inhibited and in the absence of de novo synthesis, flagella are diluted to extinction through growth Both short-term and long-term motility inhibition is likely important to stabilize cell aggregates and optimize resource investment We emphasize the newly discovered flagellar functional regulators and speculate that others await discovery in the context of biofilm formationread more
Citations
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Microfluidics for Biofilm Studies.
TL;DR: A review of microfluidics-assisted biofilm research can be found in this paper , where the authors summarize the recent progress made in micro-fluidic-based bio-film research, including understanding the mechanism of bacterial adhesion and biofilm development, assessment of antifouling and antimicrobial properties, development of advanced in vitro infection models, and advancement in methods to characterize biofilms.
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Targeted Computed Tomography Visualization and Healing of Inflammatory Bowel Disease by Orally Delivered Bacterial-Flagella-Inspired Polydiiododiacetylene Nanofibers.
Mingming Yin,Yu Chen,Xiaoming Liu,Sidan Tian,Liyuan Zhao,Y. Bai,Hao-Fei Wang,Jinfeng Lin,Dawei Jiang,Ziqiao Lei,Fanling Meng,Dean Tian,Liang Luo +12 more
TL;DR: Wang et al. as discussed by the authors reported the design of bacterial-flagella-inspired polydiiododiacetylene (PIDA) nanofibers and its performance in targeted computed tomography (CT) imaging and on-demand therapeutic intervention of inflammatory bowel disease.
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Investigating Cellulose Nanocrystals’ Biocompatibility and Their Effects on Pseudomonas syringae pv. tomato Epiphytic Survival for Sustainable Crop Protection
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Dissertation
Diversité génomique et fonctionnelle de bactéries du genre Thiomonas isolées du drainage minier acide de Carnoulès (Gard)
TL;DR: La population de Thiomonas de ce DMA serait donc composee d'au moins un ecotype stable et de souches au genome plus instable, dont le potentiel adaptatif plus important serait influence par l'As(III) et le developpement en biofilm.
References
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TL;DR: It is evident that biofilm formation is an ancient and integral component of the prokaryotic life cycle, and is a key factor for survival in diverse environments.
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Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development
George A. O'Toole,Roberto Kolter +1 more
TL;DR: The isolation and characterization of mutants of Pseudomonas aeruginosa PA14 defective in the initiation of biofilm formation on an abiotic surface, polyvinylchloride (PVC) plastic are reported and evidence that microcolonies form by aggregation of cells present in the monolayer is presented.
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