Journal ArticleDOI
Reproductive toxic potential of phthalate compounds - State of art review.
Sapna Sedha,Hoomin Lee,Siddhartha Singh,Sunil Kumar,Subodh Kumar Jain,Ajaz Ahmad,Yousef A. Bin Jardan,Sonam Sonwal,Shruti Shukla,Jesus Simal-Gandara,Jianbo Xiao,Yun Suk Huh,Young-Kyu Han,Vivek K. Bajpai +13 more
TLDR
In this paper, a review of the available literature on phthalates with respect to their reproductive toxic potential is presented, where common reproductive effects such as declined fertility, reduced testis weight, variations in accessory sex organs and several female reproductive disorders appeared to be largely associated with the transitional phthalate.About:
This article is published in Pharmacological Research.The article was published on 2021-03-04. It has received 44 citations till now. The article focuses on the topics: Phthalate & Benzyl butyl phthalate.read more
Citations
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Dibutyl phthalate release from polyvinyl chloride microplastics: Influence of plastic properties and environmental factors
Yuanyuan Yan,Fengxiao Zhu,Fengxiao Zhu,Changyin Zhu,Zhanghao Chen,Shaochong Liu,Chao Wang,Cheng Gu +7 more
TL;DR: In this article, the authors investigated the leaching behavior of phthalate plasticizer from polyvinyl chloride (PVC) microplastics, in aqueous solutions relevant to aquatic and soil environments.
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Groundwater contamination pathways of phthalates and bisphenol A: origin, characteristics, transport, and fate - A review.
TL;DR: In this article , the authors describe the groundwater contamination pathways of phthalates and BPA from the main environmental sources to groundwater, from their origin to human reception via groundwater consumption.
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Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro Tests
Marta Llorca,Marinella Farré +1 more
TL;DR: In this article, the knowledge of human exposure routes and the recent results on the toxicological effects of micro-and nanoplastics in human health are presented and discussed, and the current limitations and the main gaps in the body of knowledge are summarised.
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Emerging contaminants migration from pipes used in drinking water distribution systems: a review of the scientific literature
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Associations of environmental phthalate exposure with male steroid hormone synthesis and metabolism: An integrated epidemiology and toxicology study.
Meiping Tian,Shuangshan Wu,Yi-xin Wang,Liangpo Liu,Jie Zhang,Heqing Shen,Yanyang Lu,Huaqiong Bao,Qingyu Huang +8 more
TL;DR: In this article , the association of urinary phthalate metabolites with altered male steroid hormone synthesis and metabolism was examined using epidemiology and toxicology studies, which provides additional insights into the endocrine disrupting potential of phthalates.
References
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Journal ArticleDOI
Steroidogenesis in fetal male rats is reduced by DEHP and DINP, but endocrine effects of DEHP are not modulated by DEHA in fetal, prepubertal and adult male rats
TL;DR: DinP and DEHP were both shown to reduce testicular testosterone production ex vivo and testosterone levels in testes and plasma of male fetuses at gestation day 21, indicating a similar mechanism of action for DINP andDEHP.
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Effect of Peroxisome Proliferators on Leydig Cell Peripheral-Type Benzodiazepine Receptor Gene Expression, Hormone-Stimulated Cholesterol Transport, and Steroidogenesis: Role of the Peroxisome Proliferator-Activator Receptor α
Maria Gazouli,Zhi-Xing Yao,Noureddine Boujrad,J. Christopher Corton,Martine Culty,Vassilios Papadopoulos +5 more
TL;DR: The results suggest that the antiandrogenic effect of PPs is mediated by a PPARdependent inhibition of Leydig cell PBR gene expression.
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Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence.
TL;DR: The recent findings that prenatal exposure to phthalates affects Leydig cell function in the postnatal testis are discussed and the recent progress in understanding of how Leydenig cell factors contribute tophthalate-mediated TDS is focused on.
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Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats.
Julie Boberg,Sofie Christiansen,Marta Axelstad,Thuri Seidler Kledal,Anne Marie Vinggaard,Majken Dalgaard,Christine Nellemann,Ulla Hass +7 more
TL;DR: Results show that DinP causes anti-androgenic effects on reproductive development, though less potent than DEHP, DBP and BBP, and further safety evaluation of DINP appears warranted.
Journal ArticleDOI
Evaluation of 60 chemicals in a preliminary developmental toxicity test
Bryan D. Hardin,Ronald L. Schuler,JeAnne R. Burg,Gary M. Booth,Keith P. Hazelden,Karen M. MacKenzie,Vincent J. Piccirillo,Kirby N. Smith +7 more
TL;DR: The number of chemicals in commerce which have not been evaluated for potential developmental toxicity is large and an abbreviated assay is needed that will preliminarily evaluate otherwise untested chemicals to help prioritize them for conventional testing.