Journal ArticleDOI
Reproductive toxic potential of phthalate compounds - State of art review.
Sapna Sedha,Hoomin Lee,Siddhartha Singh,Sunil Kumar,Subodh Kumar Jain,Ajaz Ahmad,Yousef A. Bin Jardan,Sonam Sonwal,Shruti Shukla,Jesus Simal-Gandara,Jianbo Xiao,Yun Suk Huh,Young-Kyu Han,Vivek K. Bajpai +13 more
TLDR
In this paper, a review of the available literature on phthalates with respect to their reproductive toxic potential is presented, where common reproductive effects such as declined fertility, reduced testis weight, variations in accessory sex organs and several female reproductive disorders appeared to be largely associated with the transitional phthalate.About:
This article is published in Pharmacological Research.The article was published on 2021-03-04. It has received 44 citations till now. The article focuses on the topics: Phthalate & Benzyl butyl phthalate.read more
Citations
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Dibutyl phthalate release from polyvinyl chloride microplastics: Influence of plastic properties and environmental factors
Yuanyuan Yan,Fengxiao Zhu,Fengxiao Zhu,Changyin Zhu,Zhanghao Chen,Shaochong Liu,Chao Wang,Cheng Gu +7 more
TL;DR: In this article, the authors investigated the leaching behavior of phthalate plasticizer from polyvinyl chloride (PVC) microplastics, in aqueous solutions relevant to aquatic and soil environments.
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Groundwater contamination pathways of phthalates and bisphenol A: origin, characteristics, transport, and fate - A review.
TL;DR: In this article , the authors describe the groundwater contamination pathways of phthalates and BPA from the main environmental sources to groundwater, from their origin to human reception via groundwater consumption.
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Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro Tests
Marta Llorca,Marinella Farré +1 more
TL;DR: In this article, the knowledge of human exposure routes and the recent results on the toxicological effects of micro-and nanoplastics in human health are presented and discussed, and the current limitations and the main gaps in the body of knowledge are summarised.
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Emerging contaminants migration from pipes used in drinking water distribution systems: a review of the scientific literature
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Associations of environmental phthalate exposure with male steroid hormone synthesis and metabolism: An integrated epidemiology and toxicology study.
Meiping Tian,Shuangshan Wu,Yi-xin Wang,Liangpo Liu,Jie Zhang,Heqing Shen,Yanyang Lu,Huaqiong Bao,Qingyu Huang +8 more
TL;DR: In this article , the association of urinary phthalate metabolites with altered male steroid hormone synthesis and metabolism was examined using epidemiology and toxicology studies, which provides additional insights into the endocrine disrupting potential of phthalates.
References
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Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis.
TL;DR: GD 20/21 rather than GD 19 appears to be the optimal time for investigating changes in anogenital distance, testosterone levels, and testicular histopathology, and although more developmental and especially postnatal studies are needed to clearly identify the reproductive effects of DiBP, this study indicates a reason for concern about the use of Di BP as a substitute for DBP.
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Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate.
Bethany R. Hannas,Christy S. Lambright,Johnathan Furr,Kembra L. Howdeshell,Kembra L. Howdeshell,Vickie S. Wilson,Leon Earl Gray +6 more
TL;DR: Administration of dilutions of a mixture of nine phthalates reduced fetal T production in a dose-dependent manner best predicted by dose addition, and the differential effects of in utero DEHP treatment on epididymal and gubernacular differentiation in male SD and W rats are likely due to tissue-specific strain differences in the androgen and insl3 signaling pathways.
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Endocrine disrupting chemicals: Multiple effects on testicular signaling and spermatogenesis.
TL;DR: This review intends to provide environmental, epidemiological and experimental data to associate pollutant exposure with reproductive disorders, in particular on the development and function of the male reproductive system.
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Induction of lipid peroxidation during steroidogenesis in the rat testis.
TL;DR: It is suggested that physiological LH action in the rat testis causes lipid peroxidation and maintains high activities of peroxide-metabolizing enzymes in the interstitial tissue.
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Association between pregnancy loss and urinary phthalate levels around the time of conception.
Gunnar Toft,Bo A. G. Jönsson,Christian H. Lindh,Tina Kold Jensen,Niels Henrik Hjollund,Anne Vested,Jens Peter Bonde +6 more
TL;DR: Pregnancy loss was increased among women with urinary concentration of monoethylhexyl phthalate in the upper tertile in the conception sample compared with women in the lowest tertile, the first human study to show this association and the sample size is small.