Reprogramming of central carbon metabolism in cancer stem cells
Reads0
Chats0
TLDR
This perspective article summarizes the current knowledge of CSC metabolism in carcinogenesis and highlights the potential of targeting C SCs metabolism for therapy.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-07-01 and is currently open access. It has received 68 citations till now. The article focuses on the topics: Cancer stem cell & Cancer.read more
Citations
More filters
Journal Article
Stem Cells,Cancer and Cancer Stem Cells
TL;DR: Research data show that more resistant stem cells than common cancer cells exist in cancer patients, and to identify unrecognized differences between cancer stem cells and cancer cells might be able to develop effective classification, diagnose and treat for cancer.
Journal ArticleDOI
Inflammation and Metabolism in Cancer Cell-Mitochondria Key Player.
Monica Neagu,Carolina Constantin,Iulia Popescu,Donato Zipeto,George N. Tzanakakis,Dragana Nikitovic,Concettina Fenga,Constantine A. Stratakis,Demetrios A. Spandidos,Aristidis Tsatsakis +9 more
TL;DR: The expanding knowledge of the metabolic behavior of tumor cells, whether from solid tumors or hematologic malignancies, may provide the basis for the development of tailor-made cancer therapies.
Journal ArticleDOI
Role of p53 in the Regulation of the Inflammatory Tumor Microenvironment and Tumor Suppression
Ikuno Uehara,Nobuyuki Tanaka +1 more
TL;DR: Considering that the functions of p53 inhibit reprogramming of somatic cells to stem cells, p53 may have a major role in the inflammatory microenvironment as a tumor suppressor.
Journal ArticleDOI
Metabolism and epigenetics of pancreatic cancer stem cells.
M. Perusina Lanfranca,Joyce K. Thompson,Filip Bednar,Christopher J. Halbrook,Costas A. Lyssiotis,B. Levi,Timothy L. Frankel +6 more
TL;DR: Several mechanisms of cross-talk between epigenetic and metabolic pathways in PDA exist which ultimately contribute to the observed cellular plasticity and enhanced tumorigenesis.
References
More filters
Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Journal ArticleDOI
Stem cells, cancer, and cancer stem cells
TL;DR: Stem cell biology has come of age: Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
Journal ArticleDOI
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Dominique Bonnet,John E. Dick +1 more
TL;DR: It is demonstrated that the cell capable of initiating human AML in non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID mice) — termed the SCID leukemia-initiating cell, or SL-IC — possesses the differentiate and proliferative capacities and the potential for self-renewal expected of a leukemic stem cell.