Revised diagnostic criteria for neuromyelitis optica
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TLDR
Revised diagnostic criteria for definite neuromyelitis optica (NMO) that require optic neuritis, myelitis, and at least two of three supportive criteria: MRI evidence of a contiguous spinal cord lesion 3 or more segments in length, onset brain MRI nondiagnostic for multiple sclerosis, or NMO-IgG seropositivity.Abstract:
Background: The authors previously proposed diagnostic criteria for neuromyelitis optica (NMO) that facilitate its distinction from prototypic multiple sclerosis (MS) However, some patients with otherwise typical NMO have additional symptoms not attributable to optic nerve or spinal cord inflammation or have MS-like brain MRI lesions Furthermore, some patients are misclassified as NMO by the authors’ earlier proposed criteria despite having a subsequent course indistinguishable from prototypic MS A serum autoantibody marker, NMO-IgG, is highly specific for NMO The authors propose revised NMO diagnostic criteria that incorporate NMO-IgG status Methods: Using final clinical diagnosis (NMO or MS) as the reference standard, the authors calculated sensitivity and specificity for each criterion and various combinations using a sample of 96 patients with NMO and 33 with MS The authors used likelihood ratios and logistic regression analysis to develop the most practical and informative diagnostic model Results: Fourteen patients with NMO (146%) had extra-optic-spinal CNS symptoms NMO-IgG seropositivity was 76% sensitive and 94% specific for NMO The best diagnostic combination was 99% sensitive and 90% specific for NMO and consisted of at least two of three elements: longitudinally extensive cord lesion, onset brain MRI nondiagnostic for MS, or NMO-IgG seropositivity Conclusions: The authors propose revised diagnostic criteria for definite neuromyelitis optica (NMO) that require optic neuritis, myelitis, and at least two of three supportive criteria: MRI evidence of a contiguous spinal cord lesion 3 or more segments in length, onset brain MRI nondiagnostic for multiple sclerosis, or NMO-IgG seropositivity CNS involvement beyond the optic nerves and spinal cord is compatible with NMOread more
Citations
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Journal ArticleDOI
Different patterns of longitudinal brain and spinal cord changes and their associations with disability progression in NMO and MS
Yaou Liu,Yunyun Duan,Jing Huang,Zhuoqiong Ren,Zheng Liu,Huiqing Dong,Florian Weiler,Horst K. Hahn,Fu-Dong Shi,Helmut Butzkueven,Frederik Barkhof,Frederik Barkhof,Kuncheng Li +12 more
TL;DR: Spinal cord atrophy changes were associated with disability progression in NMO, while baseline brain lesion load and whole brain atrophyChanges were related to disability progressionIn MS.
Journal ArticleDOI
The clinical profile of NMOSD in Australia and New Zealand.
Wajih Bukhari,Laura Clarke,Laura Clarke,Cullen O'Gorman,Cullen O'Gorman,Elham Khalilidehkordi,Simon Arnett,Kerri Prain,Mark Woodhall,Roger Silvestrini,Christine Bundell,Sudarshini Ramanathan,David Abernethy,Sandeep Bhuta,Stefan Blum,Mike Boggild,Karyn Boundy,Bruce J. Brew,Wallace Brownlee,Helmut Butzkueven,William M. Carroll,Celia Chen,Alan Coulthard,Russell C. Dale,Chandi Das,Keith Dear,Marzena J. Fabis-Pedrini,David A. Fulcher,David Gillis,Simon Hawke,Robert Heard,Andrew P.D. Henderson,Saman Heshmat,Suzanne Hodgkinson,Sofia Jimenez-Sanchez,Trevor J. Kilpatrick,John King,Chris Kneebone,Andrew J. Kornberg,Jeannette Lechner-Scott,Ming-Wei Lin,Christopher Lynch,Richard A.L. Macdonnell,Deborah F. Mason,Pamela A. McCombe,Jennifer Pereira,John D. Pollard,Stephen W. Reddel,Cameron Shaw,Judith M. Spies,Jim Stankovich,Ian Sutton,S. Vucic,Michael Walsh,Richard C. W. Wong,Eppie M. Yiu,Michael Barnett,Allan G. Kermode,Mark Marriott,John Parratt,Mark Slee,Bruce V. Taylor,Ernest Willoughby,Robert Wilson,Fabienne Brilot,A Vincent,Patrick Waters,Simon Broadley +67 more
TL;DR: A clinic-based survey of NMOSD in the Australia and New Zealand populations with the aim of characterising the clinical features and establishing the value of recently revised diagnostic criteria demonstrated the clinical utility of the current diagnostic criteria.
Journal ArticleDOI
Relapsing optic neuritis: a multicentre study of 62 patients.
A. Benoilid,Caroline Tilikete,Nicolas Collongues,Carl Arndt,Alain Vighetto,Catherine Vignal,Jérôme De Seze +6 more
TL;DR: RON is likely a separate entity corresponding to an autoimmune disease that differs from multiple sclerosis, NMO and vasculitis and a new classification system is provided based on a better understanding of RON which could allow an improved management by early treatment of poor prognosis forms.
Journal ArticleDOI
Treatment of neuromyelitis optica.
TL;DR: Evidence supporting the use of currently available treatments for acute exacerbations and for long-term disease modification is discussed, and numerous emerging therapies that are based upon current understanding of the disease immunopathogenesis are discussed.
Journal ArticleDOI
Impact of Autologous Mesenchymal Stem Cell Infusion on Neuromyelitis Optica Spectrum Disorder: A Pilot, 2‐Year Observational Study
Ying Fu,Yaping Yan,Yuan Qi,Li Yang,Ting Li,Ningnannan Zhang,Chunshui Yu,Lei Su,Rui Zhang,Yi Shen,Song Lin,Qiang Liu,Qiang Liu,Zong-Hong Shao,Zhongchao Han,Fu-Dong Shi,Fu-Dong Shi +16 more
TL;DR: The safety and efficacy of autologous bone marrow‐derived mesenchymal stem cells as a potential treatment for neuromyelitis optica spectrum disorder (NMOSD) are evaluated.
References
More filters
Journal ArticleDOI
Applied Logistic Regression.
TL;DR: Applied Logistic Regression, Third Edition provides an easily accessible introduction to the logistic regression model and highlights the power of this model by examining the relationship between a dichotomous outcome and a set of covariables.
Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
TL;DR: The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.
Book
Clinical Epidemiology: A Basic Science for Clinical Medicine
TL;DR: Clinical Epidemiology is a book dedicated to H.L. Mencken, Kurt Vonnegut, Jr., Douglas Adams, and the Emperor's New Clothes and Physicians and others who wish to recognize key clinical epidemiologic features of the diagnosis and management of patients will benefit from reading.
Journal ArticleDOI
A serum autoantibody marker of neuromyelitis optica : distinction from multiple sclerosis
Vanda A. Lennon,Dean M. Wingerchuk,Thomas J. Kryzer,Sean J. Pittock,C. F. Lucchinetti,Kazuo Fujihara,Ichiro Nakashima,Brian G. Weinshenker +7 more
TL;DR: NMO-IgG is a specific marker autoantibody of neuromyelitis optica and binds at or near the blood-brain barrier that distinguishes neuromyleitis opticas from multiple sclerosis.
Journal ArticleDOI
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel.
TL;DR: It is shown that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier, which may represent the first example of a novel class of autoimmune channelopathy.
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