RGD-modified apoferritin nanoparticles for efficient drug delivery to tumors
Zipeng Zhen,Wei Tang,Hongmin Chen,Xin Lin,Trever Todd,Geoffrey D. Wang,Taku Cowger,Xiaoyuan Chen,Jin Xie +8 more
TLDR
It is shown that after being precomplexed with Cu(II), doxorubicin can be loaded onto RGD modified apoferritin nanocages with high efficiency and showed a longer circulation half-life, higher tumor uptake, better tumor growth inhibition, and less cardiotoxicity than free doxorbicin.Abstract:
Ferritin (FRT) is a major iron storage protein found in humans and most living organisms. Each ferritin is composed of 24 subunits, which self-assemble to form a cage-like nanostructure. FRT nanocages can be genetically modified to present a peptide sequence on the surface. Recently, we demonstrated that Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys (RGD4C)-modified ferritin can efficiently home to tumors through RGD–integrin αvβ3 interaction. Though promising, studies on evaluating surface modified ferritin nanocages as drug delivery vehicles have seldom been reported. Herein, we showed that after being precomplexed with Cu(II), doxorubicin can be loaded onto RGD modified apoferritin nanocages with high efficiency (up to 73.49 wt %). When studied on U87MG subcutaneous tumor models, these doxorubicin-loaded ferritin nanocages showed a longer circulation half-life, higher tumor uptake, better tumor growth inhibition, and less cardiotoxicity than free doxorubicin. Such a technology might be extended to load a broad r...read more
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Nanotechnology for Multimodal Synergistic Cancer Therapy
TL;DR: In this review, state-of-the-art studies concerning recent advances in nanotechnology-mediated multimodal synergistic therapy will be systematically discussed, with an emphasis on the construction of multifunctional nanomaterials for realizing bimodal and trimodal synergy therapy.
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H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection.
TL;DR: It is shown that natural H-ferritin (HFn) nanocages can carry high doses of doxorubicin (Dox) for tumor-specific targeting and killing without any targeting ligand functionalization or property modulation, which makes the HFn nanocage an ideal vehicle for efficient anticancer drug delivery.
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Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics
TL;DR: A comprehensive review on the latest remarkable advances in BBB-crossing nanotechnology, with an emphasis on the judicious design of multifunctional nanoplatforms for effective BBB penetration, efficient tumour accumulation, precise tumour imaging, and significant tumour inhibition of brain cancer.
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Drug-Induced Self-Assembly of Modified Albumins as Nano-theranostics for Tumor-Targeted Combination Therapy.
TL;DR: This work presents a new type of tumor-targeted multifunctional albumin-based nanoparticles by drug-induced self-assembly, which is a rather simple method without any sophisticated chemistry or materials engineering and is promising for multimodel imaging-guided combination therapy of cancer.
Journal ArticleDOI
Passive versus active tumor targeting using RGD- and NGR-modified polymeric nanomedicines
Sijumon Kunjachan,Robert Pola,Felix Gremse,Benjamin Theek,Josef Ehling,Diana Moeckel,Benita Hermanns-Sachweh,Michal Pechar,Karel Ulbrich,Wim E. Hennink,Gert Storm,Gert Storm,Wiltrud Lederle,Fabian Kiessling,Twan Lammers,Twan Lammers,Twan Lammers +16 more
TL;DR: It was found that vascular targeting did work, resulting in rapid and efficient early binding to tumor blood vessels, but that over time, passive targeting was significantly more efficient, leading to higher overall levels and to more efficient retention within tumors.
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