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Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics
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TLDR
A comprehensive review on the latest remarkable advances in BBB-crossing nanotechnology, with an emphasis on the judicious design of multifunctional nanoplatforms for effective BBB penetration, efficient tumour accumulation, precise tumour imaging, and significant tumour inhibition of brain cancer.Abstract:
Brain cancer, especially the most common type of glioblastoma, is highly invasive and known as one of the most devastating and deadly neoplasms. Despite surgical and medical advances, the prognosis for most brain cancer patients remains dismal and the median survival rarely exceeds 16 months. Drug delivery to the brain is significantly hindered by the existence of the blood–brain barrier (BBB), which serves as a protective semi-permeable membrane for the central nervous system. Recent breakthroughs in nanotechnology have yielded multifunctional theranostic nanoplatforms with the ability to cross or bypass the BBB, enabling accurate diagnosis and effective treatment of brain tumours. Herein, we make our efforts to present a comprehensive review on the latest remarkable advances in BBB-crossing nanotechnology, with an emphasis on the judicious design of multifunctional nanoplatforms for effective BBB penetration, efficient tumour accumulation, precise tumour imaging, and significant tumour inhibition of brain cancer. The detailed elucidation of BBB-crossing nanotechnology in this review is anticipated to attract broad interest from researchers in diverse fields to participate in the establishment of powerful BBB-crossing nanoplatforms for highly efficient brain cancer theranostics.read more
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Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis
Golnaz Morad,Golnaz Morad,Christopher V. Carman,Elliott J. Hagedorn,Elliott J. Hagedorn,Julie R. Perlin,Julie R. Perlin,Leonard I. Zon,Leonard I. Zon,Nur Mustafaoglu,Tae-Eun Park,Tae-Eun Park,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber,Cassandra C. Daisy,Marsha A. Moses,Marsha A. Moses +17 more
TL;DR: These findings identify previously unknown mechanisms by which tumor-derived EVs breach an intact BBB during the course of brain metastasis and can be leveraged to guide and inform the development of drug delivery approaches to deliver therapeutic cargoes across the BBB for treatment of a variety of brain diseases.
Journal Article
Bright Aggregation-Induced-Emission Dots for Targeted Synergetic NIR-II Fluorescence and NIR-I Photoacoustic Imaging of Orthotopic Brain Tumors
Zonghai Sheng,Bing Guo,Dehong Hu,Shidang Xu,Wenbo Wu,Weng Heng Liew,Kui Yao,Jingying Jiang,Chengbo Liu,Hairong Zheng,Bin Liu +10 more
TL;DR: The design and synthesis of a new NIR‐II fluorescent molecule with aggregation‐induced‐emission (AIE) characteristics is reported for orthotopic brain‐tumor imaging and the promise of N IR‐II AIE molecules and their dots in dual NIR-II fluorescence and Nir‐I photoacoustic imaging for precise brain cancer diagnostics is demonstrated.
Journal ArticleDOI
Nanomaterial-based blood-brain-barrier (BBB) crossing strategies
TL;DR: This review summarizes the current understanding of the physiological structure of BBB, and provides various nanomaterial-based BBB-crossing strategies for brain delivery of theranostic agents.
Journal ArticleDOI
Supramolecular cancer nanotheranostics
TL;DR: In this paper, the authors summarized the progress of supramolecular cancer nanotheranostics and provided guidance for designing new targeted theranostic agents based on extensive state-of-the-art research.
Journal ArticleDOI
Nanocarrier-based drug combination therapy for glioblastoma.
Mengnan Zhao,Demian van Straten,Marike L. D. Broekman,Véronique Préat,Raymond M. Schiffelers +4 more
TL;DR: The major issues for GBM treatment, the rationales of drug combinations with or without nanocarriers and the principle of enhanced permeability and retention effect involved in nanomedicine-based tumor targeting and promising nanodiagnostics or -therapeutics are discussed.
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