Rice bran supplementation modulates growth, microbiota and metabolome in weaning infants: a clinical trial in Nicaragua and Mali
Luis Enrique Zambrana,Starin McKeen,Hend Ibrahim,Hend Ibrahim,Iman Zarei,Erica C. Borresen,Lassina Doumbia,Abdoulaye Boré,Alima Cissoko,Seydou Douyon,Karim Kone,Johann Perez,Claudia Perez,Ann M. Hess,Zaid Abdo,Lansana Sangaré,Ababacar Maïga,Sylvia Becker-Dreps,Lijuan Yuan,Ousmane Koita,Samuel Vilchez,Elizabeth P. Ryan +21 more
TLDR
Rice bran supplementation provides nutrients, prebiotics and phytochemicals that enhance gut immunity, reduce enteric pathogens and diarrhea, and warrants attention for improvement of environmental enteric dysfunction (EED) in children in Nicaragua and Mali.Abstract:
Rice bran supplementation provides nutrients, prebiotics and phytochemicals that enhance gut immunity, reduce enteric pathogens and diarrhea, and warrants attention for improvement of environmental enteric dysfunction (EED) in children. EED is a subclinical condition associated with stunting due to impaired nutrient absorption. This study investigated the effects of rice bran supplementation on weight for age and length for age z-scores (WAZ, LAZ), EED stool biomarkers, as well as microbiota and metabolome signatures in weaning infants from 6 to 12 months old that reside in Nicaragua and Mali. Healthy infants were randomized to a control (no intervention) or a rice bran group that received daily supplementation with increasing doses at each month (1–5 g/day). Stool microbiota were characterized using 16S rDNA amplicon sequencing. Stool metabolomes were analyzed using ultra-high-performance liquid-chromatography tandem mass-spectrometry. Statistical comparisons were completed at 6, 8, and 12 months of age. Daily consumption of rice bran was safe and feasible to support changes in LAZ from 6–8 and 8–12 months of age in Nicaragua and Mali infants when compared to control. WAZ was significantly improved only for Mali infants at 8 and 12 months. Mali and Nicaraguan infants showed major differences in the overall gut microbiota and metabolome composition and structure at baseline, and thus each country cohort demonstrated distinct microbial and metabolite profile responses to rice bran supplementation when compared to control. Rice bran is a practical dietary intervention strategy that merits development in rice-growing regions that have a high prevalence of growth stunting due to malnutrition and diarrheal diseases. Rice is grown as a staple food, and the bran is used as animal feed or wasted in many low- and middle-income countries where EED and stunting is prevalent.read more
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Effect of a community-led sanitation intervention on child diarrhoea and child growth in rural Mali: a cluster-randomised controlled trial
TL;DR: In villages that received a behavioural sanitation intervention with no monetary subsidies, diarrhoeal prevalence remained similar to control villages, however, access to toilets substantially increased and child growth improved, particularly in children <2 years.
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Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC-MS based untargeted metabolomics practitioners.
Anne M. Evans,Claire O'Donovan,Mary C. Playdon,Chris Beecher,Richard D. Beger,John A. Bowden,David Broadhurst,Clary B. Clish,Surendra Dasari,Warwick B. Dunn,Julian L. Griffin,Julian L. Griffin,Thomas Hartung,Ping-Ching Hsu,Tao Huan,Judith J.M. Jans,Christina M. Jones,Maureen Kachman,Andre Kleensang,Matthew R. Lewis,María Eugenia Monge,Jonathan D. Mosley,Eric B. Taylor,Fariba Tayyari,Georgios Theodoridis,Federico Torta,Baljit K. Ubhi,Dajana Vuckovic +27 more
TL;DR: This work sought to identify and share the common and divergent QA and QC practices amongst mQACC members and collaborators who use liquid chromatography-mass spectrometry (LC-MS) in untargeted metabolomics to guide discussions for recommendations of best practices within the community and to establish internationally agreed upon reporting standards.
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Microbiota on Biotics: Probiotics, Prebiotics, and Synbiotics to Optimize Growth and Metabolism
TL;DR: This mini-review highlights recent discoveries of mechanisms underlying diet-microbial-host interactions as they pertain to growth and metabolism and discusses current and future applications of microbiota-targeting therapies in the context of child malnutrition as well as obesity and its metabolic comorbidities.
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Targeting the gut microbiota by Asian and Western dietary constituents: a new avenue for diabetes.
Abdul Rahman Conteh,Ruixue Huang +1 more
TL;DR: Based on current published observations, the gut microbiota may serve as regulator or targets by the Asian diet and Western diet, contributing to the prevention or induction of diabetes eventually.
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Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial.
Winnie K.W. So,Judy Yuet-Wa Chan,Bernard M. H. Law,Kai Chow Choi,Jessica Y.L. Ching,Kam Leung Chan,Raymond S. Tang,Carmen W.H. Chan,Justin C Y Wu,Stephen Kwok-Wing Tsui +9 more
TL;DR: In this paper, a pilot, double-blind, randomised placebo-controlled trial was conducted to assess the feasibility of implementing a long-term (24-week) rice bran dietary intervention in Chinese subjects with a high risk of colorectal cancer and to examine its effects on the composition of their intestinal microbiota.
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