Right Ventricular Function in Cardiovascular Disease, Part I Anatomy, Physiology, Aging, and Functional Assessment of the Right Ventricle
TLDR
The goal of the present review is to offer a clinical perspective on RV structure and function, using echocardiography and magnetic resonance imaging to create new opportunities for the study of RV anatomy and physiology.Abstract:
In 1616, Sir William Harvey was the first to describe the importance of right ventricular (RV) function in his seminal treatise, De Motu Cordis : “Thus the right ventricle may be said to be made for the sake of transmitting blood through the lungs, not for nourishing them.”1,2 For many years that followed, emphasis in cardiology was placed on left ventricular (LV) physiology, overshadowing the study of the RV. In the first half of the 20th century, the study of RV function was limited to a small group of investigators who were intrigued by the hypothesis that human circulation could function adequately without RV contractile function.3 Their studies, however, were based on an open pericardial dog model, which failed to take into account the complex nature of ventricular interaction. In the early 1950s through the 1970s, cardiac surgeons recognized the importance of right-sided function as they evaluated procedures to palliate right-heart hypoplasia. Since then, the importance of RV function has been recognized in heart failure, RV myocardial infarction, congenital heart disease and pulmonary hypertension. More recently, advances in echocardiography and magnetic resonance imaging have created new opportunities for the study of RV anatomy and physiology.
The goal of the present review is to offer a clinical perspective on RV structure and function. In the first part, we discuss the anatomy, physiology, aging, and assessment of the RV. In the second part, we discuss the pathophysiology, clinical importance, and management of RV failure.
### Macroscopic Anatomy of the RV
In the normal heart, the RV is the most anteriorly situated cardiac chamber and lies immediately behind the sternum. In the absence of transposition of great arteries, the RV is delimited by the annulus of the tricuspid valve and by the pulmonary valve. As suggested by Goor and Lillehi,4 the RV can be described in …read more
Citations
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Histologic and Hemodynamic Correlates of Right Ventricular Function in a Pressure Overload Model: a Study Using Three-Dimensional Speckle Tracking Echocardiography.
TL;DR: Three-dimensional speckle tracking echocardiography (STE) indices with histologic and hemodynamic parameters indicate that 3D-STE may be a valuable tool for assessment of ventricular function in RV pressure overload.
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Chronic Right Heart Failure: Expanding Prevalence and Challenges in Outpatient Management
Mwelwa Chizinga,Wassim H. Fares +1 more
TL;DR: This work reviews right heart failure management in the ambulatory setting and its challenges and focuses on adapting therapies for left ventricular heart failure to the right.
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Effective Extraction of Ventricles and Myocardium Objects from Cardiac Magnetic Resonance Images with a Multi-Task Learning U-Net
Jinchang Ren,Shashi Verma,Soufyane Frimousse,He Sun,Huimin Zhao,Hao Gao,Calum Maclellan,Sophia Zhao,Xiaoyu Luo +8 more
TL;DR: In this paper, an automatic end-to-end supervised deep learning framework is proposed, using a multi-task learning based U-Net (MTL-UNet), which introduces an edge extraction module and a fusion-based module for effectively capturing the contextual information such as continuous edges and consistent spatial patterns in terms of intensity and texture features.
Journal ArticleDOI
Management of combined pre- and post-capillary pulmonary hypertension in advanced heart failure with reduced ejection fraction
TL;DR: This review wants to highlight the expanding use of PH specific therapy and mechanical circulatory devices in the management of PH in the setting of advanced heart failure with reduced ejection fraction.
Journal ArticleDOI
Novel Approaches to Imaging the Pulmonary Vasculature and Right Heart
TL;DR: In this article , a detailed assessment of the structure and function of the right heart and pulmonary circulation can be challenging, due to the complex geometry of right ventricle, comorbid pulmonary airways and parenchymal disease, and the overlap of hemodynamic abnormalities with left heart failure.
References
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