Journal ArticleDOI
Risk of colorectal cancer in inflammatory bowel diseases.
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TLDR
Many common factors influencing the onset and advancement of IBD and CRC including the alterations in gut microbiota, changes in the interleukin pathways and tumour necrosis factor are described.About:
This article is published in Seminars in Cancer Biology.The article was published on 2020-08-01. It has received 119 citations till now. The article focuses on the topics: Crohn's disease & Ulcerative colitis.read more
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Global colorectal cancer burden in 2020 and projections to 2040
Yue Xi,Pengfei Xu +1 more
TL;DR: In this article, the authors present the global epidemiology of colorectal cancer in 2020 and projections for 2040, review the major CRC subtypes to better understand CRC molecular basis, and summarize current risk factors, prevention, and screening strategies for CRC.
Effector T Helper Cell Subsets in Inflammatory Bowel Diseases
TL;DR: Emerging evidence of how each subset of CD4+ T cells functions in promoting and sustaining the chronic inflammation that characterizes IBD is reviewed.
Journal ArticleDOI
Bile Acid-Gut Microbiota Axis in Inflammatory Bowel Disease: From Bench to Bedside.
Min Yang,Yu Gu,Lingfeng Li,Tianyu Liu,Xueli Song,Yue Sun,Xiaocang Cao,Bangmao Wang,Kui Jiang,Hailong Cao +9 more
TL;DR: In this article, the bile acid-gut microbiota axis is closely connected with IBD pathogenesis and regulation of this axis may be a novel option for treating IBD, which is a chronic, relapsing inflammatory disorder of the gastrointestinal tract, with increasing prevalence, and its pathogenesis remains unclear.
Journal ArticleDOI
Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
Xiangjin Zheng,Wan Li,Huanli Xu,Jinyi Liu,Liwen Ren,Yihui Yang,Sha Li,Jinhua Wang,Teng-Fei Ji,Guanhua Du +9 more
TL;DR: Differential gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the body.
Journal ArticleDOI
Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease.
TL;DR: In this paper, the potential of certain natural compounds and their synthetic derivatives in the prevention and treatment of inflammatory bowel disease (IBD) is discussed. But, only a few drugs present long-lasting treatment effects and issues of drug resistance and disease recurrence are frequent.
References
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Journal ArticleDOI
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Freddie Bray,Jacques Ferlay,Isabelle Soerjomataram,Rebecca L. Siegel,Lindsey A. Torre,Ahmedin Jemal +5 more
TL;DR: A status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions.
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Cancer Genome Landscapes
Bert Vogelstein,Nickolas Papadopoulos,Victor E. Velculescu,Shibin Zhou,Luis A. Diaz,Kenneth W. Kinzler +5 more
TL;DR: This work has revealed the genomic landscapes of common forms of human cancer, which consists of a small number of “mountains” (genes altered in a high percentage of tumors) and a much larger number of "hills" (Genes altered infrequently).
Journal ArticleDOI
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
Jochen Schmitz,Alexander Owyang,Elizabeth R. Oldham,Yaoli Song,Erin Murphy,Terril K. McClanahan,Gerard Zurawski,Mehrdad M. Moshrefi,Jinzhong Qin,Xiaoxia Li,Daniel M. Gorman,J. Fernando Bazan,Robert A. Kastelein +12 more
TL;DR: A member of theIL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T( H)2 cells is reported.
Journal ArticleDOI
Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences
TL;DR: Differences in incidence across age, time, and geographic region suggest that environmental factors significantly modify the expression of Crohn's disease and ulcerative colitis.
Journal ArticleDOI
The risk of colorectal cancer in ulcerative colitis: a meta-analysis
TL;DR: Using new meta-analysis techniques, the risk of CRC in UC by decade of disease and defined the risk in pancolitics and children was determined and how risk varies with geography was estimated.